Transglutaminase Induces Protofibril-like Amyloid β-Protein Assemblies That Are Protease-resistant and Inhibit Long-term Potentiation*
Hartley DM, Zhao C, Speier AC, Woodard GA, Li S, Li Z, Walz T. Transglutaminase Induces Protofibril-like Amyloid β-Protein Assemblies That Are Protease-resistant and Inhibit Long-term Potentiation*. Journal Of Biological Chemistry 2008, 283: 16790-16800. PMID: 18397883, PMCID: PMC2423271, DOI: 10.1074/jbc.m802215200.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCross-Linking ReagentsDisease ProgressionGTP-Binding ProteinsGuinea PigsHippocampusHumansInsulysinLong-Term PotentiationMiceNeprilysinPeptide HydrolasesPeptidesProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesConceptsAmyloid β-protein assemblyΒ‑Protein AssemblyDifferent aggregation patternsAggregation patternsRapid aggregationSoluble assembliesMouse hippocampus slicesAbeta assemblySoluble aggregatesAbeta oligomerizationSynthetic AbetaAssemblyAbeta protofibrilsOligomerizationTGaseGood substrateInsulin degrading enzymeConcentration 100MonomersAggregationProtofibrilsSubstrate