1993
Quantitative leukoviremia and immune complex-dissociated antigenemia as predictors of infection status in children born to mothers infected with human immunodeficiency virus type 1
Ikeda M, Andiman W, Mezger J, Shapiro E, Miller G. Quantitative leukoviremia and immune complex-dissociated antigenemia as predictors of infection status in children born to mothers infected with human immunodeficiency virus type 1. The Journal Of Pediatrics 1993, 122: 524-531. PMID: 8463895, DOI: 10.1016/s0022-3476(05)83530-9.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1Infection statusCulture resultsHIV-1-infected mothersType 1Peripheral blood mononuclear cellsSerum antigen testHIV-1 antigensBlood mononuclear cellsPositive culture resultsNegative culture resultsSeronegative donorsInfected childrenReactive antibodiesAntigen testMononuclear cellsClinical criteriaHIV-1Immune complexesCocultureChildrenPositive resultsAntigen
1987
Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus
Rowe D, Farrell P, Miller G. Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus. Virology 1987, 156: 153-162. PMID: 3027963, DOI: 10.1016/0042-6822(87)90446-6.Peer-Reviewed Original ResearchConceptsEBNA seraAntigen complexX50-7Immortalization of lymphocytesEpstein-Barr virusEBNA INovel nuclear antigenIV groupNew antigensNuclear antigenLymphocytesCell clonesWestern immunoblottingSerumCell linesEBVAntigenMolecular weight proteinsHuman serumHigh molecular weight proteinsRajiVirusViral genomeGroupWeight proteins
1986
Progressive Epstein-Barr Virus Infection
Andiman W, Katz B, Miller G. Progressive Epstein-Barr Virus Infection. 1986, 276-286. DOI: 10.1007/978-1-4612-4958-0_33.Peer-Reviewed Original ResearchEpstein-Barr virusInfectious mononucleosisEpstein-Barr virus infectionDisorders of immunitySpectrum of diseaseEBV infectionImmunologic controlFatal syndromeVirus infectionClinical conditionsNosologic entityB cellsViral replicationInfectionMononucleosisDiseaseAbnormal degreeUnchecked proliferationImmunopathogenesisRelapsingNeoplasiaSyndromeAntigenImmunity
1985
Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1.
Rowe D, Heston L, Metlay J, Miller G. Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 7429-7433. PMID: 2997790, PMCID: PMC391358, DOI: 10.1073/pnas.82.21.7429.Peer-Reviewed Original ResearchConceptsChronic active EBV infectionActive EBV infectionEpstein-Barr virusJijoye strainEBV infectionEBV DNACertain patientsP3HR-1Human antiseraVirus strainsNuclear antigenHr-1JijoyeVirus deletion mutantsLtk- cellsMouse Ltk- cellsImmortalization processPatientsGene transferNeoantigensLymphocytesInfectionAntigenAntibody Responses to Two Epstein-Barr Virus Nuclear Antigens Defined by Gene Transfer
Miller G, Grogan E, Fischer D, Niederman J, Schooley R, Henle W, Lenoir G, Liu C. Antibody Responses to Two Epstein-Barr Virus Nuclear Antigens Defined by Gene Transfer. New England Journal Of Medicine 1985, 312: 750-755. PMID: 2983211, DOI: 10.1056/nejm198503213121204.Peer-Reviewed Original ResearchConceptsChronic active EBV infectionActive EBV infectionEBV infectionNuclear antigenEpstein-Barr virus nuclear antigenEpstein-Barr virus DNAEBV-seropositive subjectsAbnormal immune responseAssociation of EBVNorth African patientsAbsence of antibodiesSuch patientsAfrican patientsSerologic studiesImmune responseNasopharyngeal carcinomaLymphoid cellsPatientsViral gene productsSpecific viral gene productsViral mutationsSerologic reactionsAntigenSerum samplesM antigenConstitutive expression of Epstein-Barr virus-encoded RNAs and nuclear antigen during latency and after induction of Epstein-Barr virus replication
Weigel R, Fischer D, Heston L, Miller G. Constitutive expression of Epstein-Barr virus-encoded RNAs and nuclear antigen during latency and after induction of Epstein-Barr virus replication. Journal Of Virology 1985, 53: 254-259. PMID: 2981344, PMCID: PMC255024, DOI: 10.1128/jvi.53.1.254-259.1985.Peer-Reviewed Original ResearchConceptsEpstein-Barr virus-encoded RNAVirus-encoded RNAEpstein-Barr virus replicationNuclear antigenEpstein-Barr virusLatent gene productsEpstein-Barr virus gene productsHR-1 cellsVirus gene productsViral variantsVirus replicationAntigen mRNAAbsence of inductionViral DNAAntigenInductionMethod of inductionPhorbol esterViral polypeptidesViral transcriptsGene productsCytoplasmic abundanceExpressionConstitutive expressionConstitutive levels
1984
Epstein-Barr virus with heterogeneous DNA disrupts latency
Miller G, Rabson M, Heston L. Epstein-Barr virus with heterogeneous DNA disrupts latency. Journal Of Virology 1984, 50: 174-182. PMID: 6321789, PMCID: PMC255597, DOI: 10.1128/jvi.50.1.174-182.1984.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusLatent Epstein-Barr virusEarly antigenRaji cellsViral synthesisX50-7 cellsHet DNABurkitt lymphoma linesActivated virusEBV DNANeonatal lymphocytesEBV replicationEBV sequencesX50-7Restriction endonuclease polymorphismAntigenLymphoma linesVirusRare variantsDefective virusLower ratesSuperinfectionCell spreadBiological effectsCells
1983
Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells.
Rabson M, Heston L, Miller G. Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 2762-2766. PMID: 6302703, PMCID: PMC393908, DOI: 10.1073/pnas.80.9.2762.Peer-Reviewed Original Research
1982
Neutralization of lymphocyte immortalization by different strains of Epstein-Barr virus with a murine monoclonal antibody
Miller G, Heston L, Hoffman G. Neutralization of lymphocyte immortalization by different strains of Epstein-Barr virus with a murine monoclonal antibody. Infection And Immunity 1982, 37: 1028-1031. PMID: 6182100, PMCID: PMC347642, DOI: 10.1128/iai.37.3.1028-1031.1982.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusMurine monoclonal antibodiesMonoclonal antibodiesCases of mononucleosisB95-8 strainBurkitt's lymphoma cell linesPolyclonal lymphomaBlood transfusionEBV strainsAmerican patientsChallenge virusLymphoma cell linesBurkitt's lymphomaLymphocyte immortalizationAfrican childrenHybridoma antibodiesAntigenic differencesAntibodiesMarmoset cellsMononucleosisVirusAntigenic sitesCell linesLymphomaAntigen
1981
Epstein-Barr Viral DNA: Infectivity for Human Placental Cells
Miller G, Grogan E, Heston L, Robinson J, Smith D. Epstein-Barr Viral DNA: Infectivity for Human Placental Cells. Science 1981, 212: 452-455. PMID: 6259735, DOI: 10.1126/science.6259735.Peer-Reviewed Original Research
1979
Experimental Carcinogenicity by the Virus In Vivo
Miller G. Experimental Carcinogenicity by the Virus In Vivo. 1979, 351-372. DOI: 10.1007/978-3-642-67236-1_16.Peer-Reviewed Original ResearchEpstein-Barr virusEBV nuclear antigenBurkitt's lymphomaEBV DNA copiesHuman EBV infectionEBV infectionLymphoid folliclesLymphoproliferative syndromeMalignant diseaseGerminal centersLymphoid neoplasmsNew World primatesNuclear antigenSpectrum of responsesOwl monkeysLymphomaInfectionExperimental carcinogenicityVirusDNA copiesNeoplasmsSyndromeTumorsAntigenDisease
1975
Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference.
Miller G, Robinson J, Heston L, Lipman M. Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference. IARC Scientific Publications 1975, 395-408. PMID: 190145.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEarly antigenH virusInitiation of immortalizationAntibody-negative human serumPretreatment of lymphocytesNon-producer cell linesCell linesHuman umbilical cordHuman serumInfectious mononucleosisCarrier cell linesB95-8Umbilical cordBurkitt's lymphomaLymphocyte immortalizationDNA synthesisLaboratory strainsStimulation of DNAHuman lymphocytesLymphocytesBiological behaviorPrimary culturesAbortive infectionAntigen
1974
Expression of Epstein-Barr viral capsid, complement fixing, and nuclear antigens in stationary and exponential phase cultures.
Miller G, Heston L. Expression of Epstein-Barr viral capsid, complement fixing, and nuclear antigens in stationary and exponential phase cultures. The Yale Journal Of Biology And Medicine 1974, 47: 123-35. PMID: 4372815, PMCID: PMC2596417.Peer-Reviewed Original ResearchConceptsViral capsid antigenEpstein-Barr viralCapsid antigenNuclear antigenComplement fixingContinuous lymphoblastoid cell linesEpstein-Barr viral capsidViable cellsContent of antigensProportion of cellsLymphocyte transformationAnticomplement immunofluorescenceLymphoblastoid cell linesComplement-fixing (CF) antigenCell subpopulationsComplement fixationAntigenAntigen complexIntranuclear antigensProducer linesCell linesCells
1972
Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset Leukocytes
Miller G, Shope T, Lisco H, Stitt D, Lipman M. Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset Leukocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1972, 69: 383-387. PMID: 4333982, PMCID: PMC426463, DOI: 10.1073/pnas.69.2.383.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Antibody ReactionsAntigens, ViralCattleCell LineCell Transformation, NeoplasticCells, CulturedChromosomesComplement Fixation TestsCytopathogenic Effect, ViralFetusFibroblastsFluorescent Antibody TechniqueHaplorhiniHerpesviridaeHerpesvirus 4, HumanHumansImmune SeraKidneyLeukocytesPathologyPlacentaConceptsEpstein-Barr virus antigensEpstein-Barr virusVirus antigenGiant cellsMultinucleate giant cellsViral antigensBlood leukocytesCytopathic changesNew World primatesInfectious virusIntranuclear inclusionsSquirrel monkeysAntigenLymphoblastoid cellsVirusLeukocytesWorld primatesSimian cellsCellsLarge proportionMultinucleate cells
1970
Epstein-Barr Viral Antigen in Single Cell Clones of Two Human Leukocytic Lines
Miller M, Stitt D, Miller G. Epstein-Barr Viral Antigen in Single Cell Clones of Two Human Leukocytic Lines. Journal Of Virology 1970, 6: 699-701. PMID: 4320703, PMCID: PMC376178, DOI: 10.1128/jvi.6.5.699-701.1970.Peer-Reviewed Original Research
1969
Establishment of Lines from Normal Human Blood Leukocytes by Co-cultivation with a Leukocyte Line Derived from a Leukemic Child 1
Miller G, Enders J, Lisco H, Kohn H. Establishment of Lines from Normal Human Blood Leukocytes by Co-cultivation with a Leukocyte Line Derived from a Leukemic Child 1. Experimental Biology And Medicine 1969, 132: 247-252. PMID: 4899209, DOI: 10.3181/00379727-132-34189.Peer-Reviewed Original ResearchConceptsCancer Research FoundationWhite blood cellsHuman placental cellsHuman blood leukocytesNormal human blood leukocytesNormal adult malesEBV antigensChildren 1Blood leukocytesPlacental cellsClinical specimensBlood cellsPossible roleEBVLeukocytesAntigenAdult malesCellsLeukocyte linesCulture system