1999
Role of the Epstein-Barr Virus Rta Protein in Activation of Distinct Classes of Viral Lytic Cycle Genes
Ragoczy T, Miller G. Role of the Epstein-Barr Virus Rta Protein in Activation of Distinct Classes of Viral Lytic Cycle Genes. Journal Of Virology 1999, 73: 9858-9866. PMID: 10559298, PMCID: PMC113035, DOI: 10.1128/jvi.73.12.9858-9866.1999.Peer-Reviewed Original ResearchConceptsLytic cycle genesRaji cellsEpstein–Barr virus Rta proteinEpstein-Barr virus (EBV) lytic cycleViral targetsLytic cycleVirus lytic cycleLymphoma cell line RajiBurkitt's lymphoma cell line RajiBZLF1 expressionB cell linesCell line RajiBRLF1 geneImmediate early genesInhibitory effectCycle genesViral lytic cycle genesEBVRta proteinViral genesBLRF2CellsExpressionTransactivation functionLate genes
1998
The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes
Ragoczy T, Heston L, Miller G. The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes. Journal Of Virology 1998, 72: 7978-7984. PMID: 9733836, PMCID: PMC110133, DOI: 10.1128/jvi.72.10.7978-7984.1998.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceB-LymphocytesCell LineChloramphenicol O-AcetyltransferaseDNA PrimersDNA ReplicationDNA-Binding ProteinsGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmediate-Early ProteinsPromoter Regions, GeneticTrans-ActivatorsTranscription FactorsViral ProteinsVirus LatencyConceptsEpstein-Barr virusLytic cycle genesB lymphocytesEpstein–Barr virus Rta proteinEpithelial cellsLytic cycleDisruption of latencyViral lytic cycleB cell linesEBV entryImmediate early viral genesBZLF1LymphocytesCycle genesExpression of RTARTA functionBRLF1Rta proteinDownstream targetsViral genesViral DNA replicationExpressionCells
1991
Relation between HIV-1 syncytium inhibition antibodies and clinical outcome in children
Brenner TJ, Dahl KE, Miller G, Andiman W, Andiman WA, Olson B, Miller G, Andiman W, Miller G. Relation between HIV-1 syncytium inhibition antibodies and clinical outcome in children. The Lancet 1991, 337: 1001-1005. PMID: 1673167, DOI: 10.1016/0140-6736(91)92660-t.Peer-Reviewed Original ResearchConceptsLymphocytic interstitial pneumonitisOpportunistic infectionsClinical outcomesSyncytium formationCD4 receptorHIV-1-infected mothersWestern blotHIV-1 infected cellsInterstitial pneumonitisInhibition antibodiesHIV-1Giant cellsIndicator cellsAntibodiesInfected cellsTitresChildrenCell linesCell spreadSerumReceptorsOutcomesVirusCellsPneumonitis
1990
Topological Effects of EBNA 1 on oriP
Orlowski R, Miller G. Topological Effects of EBNA 1 on oriP. Advances In Experimental Medicine And Biology 1990, 278: 115-124. PMID: 1963028, DOI: 10.1007/978-1-4684-5853-4_12.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigens, ViralBase SequenceBinding SitesDeoxyribonuclease IV (Phage T4-Induced)DNA, SuperhelicalDNA, ViralEndodeoxyribonucleasesEpstein-Barr Virus Nuclear AntigensEscherichia coliEscherichia coli ProteinsGenes, ViralHerpesvirus 4, HumanMolecular Sequence DataNucleic Acid ConformationPlasmidsRecombinant ProteinsRepetitive Sequences, Nucleic AcidTransformation, Bacterial
1985
Epstein-Barr Virus Genomes Are Restricted to Secondary Neoplastic Cells Following Bone Marrow Transplantation
Schubach W, Miller G, Thomas E. Epstein-Barr Virus Genomes Are Restricted to Secondary Neoplastic Cells Following Bone Marrow Transplantation. Blood 1985, 65: 535-538. DOI: 10.1182/blood.v65.3.535.535.Peer-Reviewed Original ResearchBone marrow transplantationEpstein-Barr virusMarrow transplantationB-cell neoplasmsEBV genomeCell neoplasmsEpstein-Barr virus genomeLong-term remissionGroup of patientsCells of patientsEngrafted lymphocytesMononuclear bloodRecurrent leukemiaSecondary neoplasmsMononuclear cellsOriginal leukemiaPatient categoriesNeoplastic cellsPatientsTumor cellsTransplantationNeoplasmsLeukemiaCellsVirus genome
1984
Epstein-Barr virus with heterogeneous DNA disrupts latency
Miller G, Rabson M, Heston L. Epstein-Barr virus with heterogeneous DNA disrupts latency. Journal Of Virology 1984, 50: 174-182. PMID: 6321789, PMCID: PMC255597, DOI: 10.1128/jvi.50.1.174-182.1984.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusLatent Epstein-Barr virusEarly antigenRaji cellsViral synthesisX50-7 cellsHet DNABurkitt lymphoma linesActivated virusEBV DNANeonatal lymphocytesEBV replicationEBV sequencesX50-7Restriction endonuclease polymorphismAntigenLymphoma linesVirusRare variantsDefective virusLower ratesSuperinfectionCell spreadBiological effectsCells
1983
Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells.
Rabson M, Heston L, Miller G. Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 2762-2766. PMID: 6302703, PMCID: PMC393908, DOI: 10.1073/pnas.80.9.2762.Peer-Reviewed Original Research
1982
Biology of Lymphoid Cells Transformed by Epstein—Barr Virus
Robinson J, Miller G. Biology of Lymphoid Cells Transformed by Epstein—Barr Virus. The Viruses 1982, 151-207. DOI: 10.1007/978-1-4684-4163-5_4.Peer-Reviewed Original ResearchInfectious mononucleosisBurkitt's lymphomaLymphoblastoid cell linesContinuous lymphoblastoid cell linesEpstein-Barr virusSubsequent electron microscopic examinationBL tissuesBL tumorsElectron microscopic examinationLymphoid cellsHerpesvirus groupNormal individualsLymphoid linesFraction of cellsPatientsViral particlesCell linesVirus particlesCellsMononucleosisLymphomaMalignancyTumorsNew Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma
Heston L, Rabson M, Brown N, Miller G. New Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma. Nature 1982, 295: 160-163. PMID: 6276755, DOI: 10.1038/295160a0.Peer-Reviewed Original Research
1981
Epstein-Barr Viral DNA: Infectivity for Human Placental Cells
Miller G, Grogan E, Heston L, Robinson J, Smith D. Epstein-Barr Viral DNA: Infectivity for Human Placental Cells. Science 1981, 212: 452-455. PMID: 6259735, DOI: 10.1126/science.6259735.Peer-Reviewed Original Research
1979
SITE OF EPSTEIN-BARR VIRUS REPLICATION IN THE OROPHARYNX
Morgan DG, Miller G, Niederman J, Smith HW, Dowaliby JM. SITE OF EPSTEIN-BARR VIRUS REPLICATION IN THE OROPHARYNX. The Lancet 1979, 314: 1154-1157. PMID: 91888, DOI: 10.1016/s0140-6736(79)92384-5.Peer-Reviewed Original ResearchConceptsInfectious Epstein-Barr virusEpstein-Barr virus replicationAcute infectious mononucleosisEpstein-Barr virusInfectious mononucleosisPatient's virusThroat washingsViral antigensEBV productionTonsillar lymphocytesInfectious virusVirus replicationParotid secretionPatientsCell-free formSalivary glandsOropharynxVirusSecretionCell-free materialSalivaMononucleosisCellsTonsillectomyLymphocytes
1974
Expression of Epstein-Barr viral capsid, complement fixing, and nuclear antigens in stationary and exponential phase cultures.
Miller G, Heston L. Expression of Epstein-Barr viral capsid, complement fixing, and nuclear antigens in stationary and exponential phase cultures. The Yale Journal Of Biology And Medicine 1974, 47: 123-35. PMID: 4372815, PMCID: PMC2596417.Peer-Reviewed Original ResearchConceptsViral capsid antigenEpstein-Barr viralCapsid antigenNuclear antigenComplement fixingContinuous lymphoblastoid cell linesEpstein-Barr viral capsidViable cellsContent of antigensProportion of cellsLymphocyte transformationAnticomplement immunofluorescenceLymphoblastoid cell linesComplement-fixing (CF) antigenCell subpopulationsComplement fixationAntigenAntigen complexIntranuclear antigensProducer linesCell linesCells
1973
Malignant Lymphoma in Cottontop Marmosets after Inoculation with Epstein-Barr Virus
Shope T, Dechairo D, Miller G. Malignant Lymphoma in Cottontop Marmosets after Inoculation with Epstein-Barr Virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1973, 70: 2487-2491. PMID: 4354852, PMCID: PMC427039, DOI: 10.1073/pnas.70.9.2487.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusMalignant lymphomaImmunosuppressive drugsCottontop marmosetsCell-free Epstein-Barr virusCourse of diseaseCell-free virusHuman malignant lymphomasSarcoma typesVirus antigenAddition of virusLymphomaAutologous cellsTumor formationLatent periodOncogenic capacityOrgan cultureMarmosetsVirusTumorsAntibodiesDrugsAdditional evidenceCellsNeoplasia
1972
Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset Leukocytes
Miller G, Shope T, Lisco H, Stitt D, Lipman M. Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset Leukocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1972, 69: 383-387. PMID: 4333982, PMCID: PMC426463, DOI: 10.1073/pnas.69.2.383.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Antibody ReactionsAntigens, ViralCattleCell LineCell Transformation, NeoplasticCells, CulturedChromosomesComplement Fixation TestsCytopathogenic Effect, ViralFetusFibroblastsFluorescent Antibody TechniqueHaplorhiniHerpesviridaeHerpesvirus 4, HumanHumansImmune SeraKidneyLeukocytesPathologyPlacentaConceptsEpstein-Barr virus antigensEpstein-Barr virusVirus antigenGiant cellsMultinucleate giant cellsViral antigensBlood leukocytesCytopathic changesNew World primatesInfectious virusIntranuclear inclusionsSquirrel monkeysAntigenLymphoblastoid cellsVirusLeukocytesWorld primatesSimian cellsCellsLarge proportionMultinucleate cells
1970
Epstein-Barr Viral Antigen in Single Cell Clones of Two Human Leukocytic Lines
Miller M, Stitt D, Miller G. Epstein-Barr Viral Antigen in Single Cell Clones of Two Human Leukocytic Lines. Journal Of Virology 1970, 6: 699-701. PMID: 4320703, PMCID: PMC376178, DOI: 10.1128/jvi.6.5.699-701.1970.Peer-Reviewed Original Research
1969
Establishment of Lines from Normal Human Blood Leukocytes by Co-cultivation with a Leukocyte Line Derived from a Leukemic Child 1
Miller G, Enders J, Lisco H, Kohn H. Establishment of Lines from Normal Human Blood Leukocytes by Co-cultivation with a Leukocyte Line Derived from a Leukemic Child 1. Experimental Biology And Medicine 1969, 132: 247-252. PMID: 4899209, DOI: 10.3181/00379727-132-34189.Peer-Reviewed Original ResearchConceptsCancer Research FoundationWhite blood cellsHuman placental cellsHuman blood leukocytesNormal human blood leukocytesNormal adult malesEBV antigensChildren 1Blood leukocytesPlacental cellsClinical specimensBlood cellsPossible roleEBVLeukocytesAntigenAdult malesCellsLeukocyte linesCulture system