2019
Cellular Genes Involved in Redox Regulation Are Altered by Inhibitors of Epstein‐Barr Virus Lytic Gene Expression
Gorres K, Miller G. Cellular Genes Involved in Redox Regulation Are Altered by Inhibitors of Epstein‐Barr Virus Lytic Gene Expression. The FASEB Journal 2019, 33: 458.11-458.11. DOI: 10.1096/fasebj.2019.33.1_supplement.458.11.Peer-Reviewed Original ResearchViral lytic gene expressionLytic gene expressionCellular genesGene expressionViral lytic cycleLytic cycleEpstein-Barr virusNext-generation RNA sequencingViral immediate-early genesCellular gene expressionImmediate early genesRedox regulationTranscription factorsRNA sequencingCellular pathwaysGenesEnvironmental stimuliHuman cancersRedox statusMore virionsEBV-positive cellsFASEB JournalFull-text articlesExpressionViral lytic cascade
2001
Autostimulation of the Epstein-Barr Virus BRLF1 Promoter Is Mediated through Consensus Sp1 and Sp3 Binding Sites
Ragoczy T, Miller G. Autostimulation of the Epstein-Barr Virus BRLF1 Promoter Is Mediated through Consensus Sp1 and Sp3 Binding Sites. Journal Of Virology 2001, 75: 5240-5251. PMID: 11333906, PMCID: PMC114930, DOI: 10.1128/jvi.75.11.5240-5251.2001.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesBase SequenceBinding SitesCell Line, TransformedDNA-Binding ProteinsGene DeletionGene Expression Regulation, ViralHerpesvirus 4, HumanHeterotrimeric GTP-Binding ProteinsHumansImmediate-Early ProteinsMolecular Sequence DataMutagenesis, Site-DirectedPromoter Regions, GeneticProtein BindingReceptors, Cell SurfaceSp1 Transcription FactorSp3 Transcription FactorTrans-ActivatorsTranscription FactorsViral ProteinsVirus ActivationConceptsSp1/Sp3 siteLytic cycleSp3 transcription factorsBinding of Sp1Transcriptional start siteSite-directed mutagenesisGel shift analysisBRLF1 promoterReporter-based assaysEpstein–Barr virus Rta proteinCellular Sp1Own geneConsensus Sp1Transcriptional activationCellular proteinsTranscription factorsStart siteDNA bindingOwn expressionMutagenesis studiesRta proteinSp1Reporter activityTranscription factor Zif268B cells
2000
Dihydrofolate Reductase from Kaposi's Sarcoma-Associated Herpesvirus
Cinquina C, Grogan E, Sun R, Lin S, Beardsley G, Miller G. Dihydrofolate Reductase from Kaposi's Sarcoma-Associated Herpesvirus. Virology 2000, 268: 201-217. PMID: 10683342, DOI: 10.1006/viro.1999.0165.Peer-Reviewed Original ResearchConceptsKaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusDihydrofolate reductaseEarly lytic cycle genesNucleotide metabolism genesDHFR activityHuman DHFRViral enzymesPrimary effusion lymphomaLytic cycle genesKSHV lytic cycleMethionine biosynthesisCycle genesHuman dihydrofolate reductaseCultured B-cell linesMetabolism genesPEL cell linesOwn enzymesB cell linesAmino acidsPEL cellsChemical inductionLytic cycleE. coliInfected cells
1999
Role of the Epstein-Barr Virus Rta Protein in Activation of Distinct Classes of Viral Lytic Cycle Genes
Ragoczy T, Miller G. Role of the Epstein-Barr Virus Rta Protein in Activation of Distinct Classes of Viral Lytic Cycle Genes. Journal Of Virology 1999, 73: 9858-9866. PMID: 10559298, PMCID: PMC113035, DOI: 10.1128/jvi.73.12.9858-9866.1999.Peer-Reviewed Original ResearchConceptsLytic cycle genesRaji cellsEpstein–Barr virus Rta proteinEpstein-Barr virus (EBV) lytic cycleViral targetsLytic cycleVirus lytic cycleLymphoma cell line RajiBurkitt's lymphoma cell line RajiBZLF1 expressionB cell linesCell line RajiBRLF1 geneImmediate early genesInhibitory effectCycle genesViral lytic cycle genesEBVRta proteinViral genesBLRF2CellsExpressionTransactivation functionLate genesKinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression
Sun R, Lin S, Staskus K, Gradoville L, Grogan E, Haase A, Miller G. Kinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression. Journal Of Virology 1999, 73: 2232-2242. PMID: 9971806, PMCID: PMC104468, DOI: 10.1128/jvi.73.3.2232-2242.1999.Peer-Reviewed Original ResearchConceptsHerpesvirus gene expressionKaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusGene expressionLytic cycleEarly genesVIL-6Cell linesKSHV DNA replicationG protein-coupled receptorsProtein-coupled receptorsSingle-cell assaysPrimary effusion lymphoma cell linesImmediate early genesPAN RNADNA replicationEpstein-Barr virus BZLF1Nuclear RNALate genesBovine herpesvirus 4KS biopsiesPEL cell linesVBcl-2Positional homologueKinetic classes
1998
The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes
Ragoczy T, Heston L, Miller G. The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes. Journal Of Virology 1998, 72: 7978-7984. PMID: 9733836, PMCID: PMC110133, DOI: 10.1128/jvi.72.10.7978-7984.1998.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceB-LymphocytesCell LineChloramphenicol O-AcetyltransferaseDNA PrimersDNA ReplicationDNA-Binding ProteinsGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmediate-Early ProteinsPromoter Regions, GeneticTrans-ActivatorsTranscription FactorsViral ProteinsVirus LatencyConceptsEpstein-Barr virusLytic cycle genesB lymphocytesEpstein–Barr virus Rta proteinEpithelial cellsLytic cycleDisruption of latencyViral lytic cycleB cell linesEBV entryImmediate early viral genesBZLF1LymphocytesCycle genesExpression of RTARTA functionBRLF1Rta proteinDownstream targetsViral genesViral DNA replicationExpressionCells