Effect of metformin treatment on insulin action in diabetic rats: In vivo and in vitro correlations
Rossetti L, DeFronzo R, Gherzi R, Stein P, Andraghetti G, Falzetti G, Shulman G, Klein-Robbenhaar E, Cordera R. Effect of metformin treatment on insulin action in diabetic rats: In vivo and in vitro correlations. Metabolism 1990, 39: 425-435. PMID: 2157941, DOI: 10.1016/0026-0495(90)90259-f.Peer-Reviewed Original ResearchConceptsInsulin receptor tyrosine kinase activityDiabetic ratsMetformin treatmentReceptor tyrosine kinase activityTyrosine kinase activitySupernormal levelsGlucose disposalInsulin-mediated whole-body glucose disposalTotal body insulin-mediated glucose disposalInsulin actionNeonatal streptozotocin diabetic ratsTotal body glucose uptakeInsulin-mediated glucose disposalWhole-body glucose disposalGlucose uptakeDeficient insulin responseNormalized glucose toleranceInsulin clamp studiesStreptozotocin-diabetic ratsVivo insulin actionHepatic glucose productionMuscle glycogen synthesisGlycogen synthesisSynthetic rateGlucose toleranceQuantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by 13C Nuclear Magnetic Resonance Spectroscopy
Shulman G, Rothman D, Jue T, Stein P, DeFronzo R, Shulman R. Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by 13C Nuclear Magnetic Resonance Spectroscopy. New England Journal Of Medicine 1990, 322: 223-228. PMID: 2403659, DOI: 10.1056/nejm199001253220403.Peer-Reviewed Original ResearchConceptsMuscle glycogen synthesisNonoxidative glucose metabolismDiabetic subjectsNormal subjectsGlucose metabolismMuscle glycogenGlycogen synthesisHyperglycemic-hyperinsulinemic clamp studiesTotal body glucose uptakeWeight-matched healthy subjectsNon-insulin dependent diabetesSteady-state plasma concentrationsGlucose uptakeMean glucose uptakeDependent diabetes mellitusDiabetes mellitusInsulin resistanceGlucose disposalPlasma concentrationsHealthy subjectsStudy groupClamp studiesGastrocnemius muscleInsulin actionMean rate