Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans
Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman GI, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC. Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nature Medicine 2019, 25: 1739-1747. PMID: 31700183, PMCID: PMC7256970, DOI: 10.1038/s41591-019-0610-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody Mass IndexCell DedifferentiationComplement C3aComplement Factor DDiabetes Mellitus, Type 2Dual-Specificity PhosphatasesGlucoseHumansHyperglycemiaInsulinInsulin ResistanceInsulin-Secreting CellsMiceMice, Inbred NODMitogen-Activated Protein Kinase PhosphatasesConceptsType 2 diabetesBody mass indexBeta cellsDiabetic miceInsulin secretagoguesDiabetic db/db miceDb/db micePancreatic beta-cell massBeta cell healthBeta-cell failureBeta-cell lossBeta-cell massComplement components C3aMiddle-aged adultsHuman islet cellsAlternative complement pathwayComplement factor DFuture diabetesMass indexInsulin levelsDb miceInsulin resistanceLower riskType 2Cell loss