2024
Tumour necrosis is a valuable histopathological prognostic parameter in melanomas of the vulva and vagina
Roy S, Baig J, DeCoste R, Finch S, Sennik S, Kakadekar A, Sade S, Micevic G, Chergui M, Rahimi K, Flaman A, Trinh V, Osmond A. Tumour necrosis is a valuable histopathological prognostic parameter in melanomas of the vulva and vagina. Pathology 2024, 56: 854-864. PMID: 38906758, DOI: 10.1016/j.pathol.2024.03.008.Peer-Reviewed Original ResearchTumor necrosisVaginal melanomaPrognostic factorsDisease-specific mortalitySurvival outcomesKaplan-Meier log-rankAssociated with disease-specific mortalityKaplan-Meier survival analysisPositive lymph nodesHistopathological prognostic parametersMedian follow-upMetastasis-free survivalNon-metastatic patientsMultivariate Cox regressionTime to metastasisFollow-up dataTertiary Canadian hospitalProgression-freeTumor ulcerationMelanoma patientsPrognostic parametersLymph nodesAggressive malignancyImmunohistochemical markersLog-rank
2018
PD‐L1 methylation regulates PD‐L1 expression and is associated with melanoma survival
Micevic G, Thakral D, McGeary M, Bosenberg M. PD‐L1 methylation regulates PD‐L1 expression and is associated with melanoma survival. Pigment Cell & Melanoma Research 2018, 32: 435-440. PMID: 30343532, PMCID: PMC6475614, DOI: 10.1111/pcmr.12745.Peer-Reviewed Original ResearchConceptsPD-L1 expressionDNA methylationPD-1/PD-L1 immune checkpointIndependent survival prognostic factorPD-L1 promoter methylationPD-L1 immune checkpointSurvival prognostic factorsPD-L1 promoterPromoter DNA methylationOverall survivalImmune checkpointsPrognostic factorsMelanoma patientsMelanoma survivalEpigenetic mechanismsTranscriptional phenotypeClinical importanceMelanomaCpG lociMethylationPromoter methylationSurvivalTherapeutic applicationsExpressionPatients