2019
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression
Malvi P, Janostiak R, Nagarajan A, Cai G, Wajapeyee N. Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression. PLOS Genetics 2019, 15: e1008439. PMID: 31589613, PMCID: PMC6797230, DOI: 10.1371/journal.pgen.1008439.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAdultAgedAnimalsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationDatasets as TopicDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGrowth Differentiation Factor 15HumansLungLung NeoplasmsMaleMiceMiddle AgedNeoplasm Recurrence, LocalPrognosisSurvival AnalysisThymidine KinaseTranscription FactorsXenograft Model Antitumor AssaysConceptsShort hairpin RNALUAD cellsMetastatic attributesRho GTPase activityMAP kinase pathwayEctopic expressionGTPase activityTranscriptional overexpressionKinase pathwayKinase 1Cancer cell growthGenetic knockdownProfiling-based approachDifferentiation factor 15Hairpin RNALung adenocarcinoma patientsLung cancer growthCell growthLUAD therapyDownstream mediatorLUAD tumorsLUAD growthKey hallmarksReduced expressionDependent mannerGrading Pancreatic Neuroendocrine Tumors by Ki-67 Index Evaluated on Fine-Needle Aspiration Cell Block Material
Abi-Raad R, Lavik JP, Barbieri AL, Zhang X, Adeniran AJ, Cai G. Grading Pancreatic Neuroendocrine Tumors by Ki-67 Index Evaluated on Fine-Needle Aspiration Cell Block Material. American Journal Of Clinical Pathology 2019, 153: 74-81. PMID: 31415691, DOI: 10.1093/ajcp/aqz110.Peer-Reviewed Original Research
2013
Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐up
Karunamurthy A, Cai G, Dacic S, Khalbuss WE, Pantanowitz L, Monaco SE. Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐up. Cancer Cytopathology 2013, 122: 23-32. PMID: 24127207, DOI: 10.1002/cncy.21350.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsy, NeedleCohort StudiesDatabases, FactualEndoscopic Ultrasound-Guided Fine Needle AspirationFalse Negative ReactionsFemaleHumansImmunohistochemistryLung NeoplasmsLymph NodesMaleMediastinal NeoplasmsMiddle AgedRetrospective StudiesSensitivity and SpecificityConceptsEndobronchial ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationLymph nodesFine-needle aspirationDiagnostic yieldN1 lymph nodesN2 lymph nodesNegative cytologic diagnosisHilar lymph nodesMediastinal lymph nodesOverall diagnostic yieldChance of malignancyHigh diagnostic yieldNegative predictive valueFalse-negative diagnosesClinicopathologic findingsMediastinal lesionsLymphoid tissueInvasive modalitiesCytologic diagnosisPredictive valueUnsatisfactory casesGreater riskHistologicDiagnostic materialIdentification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma
Cai G, Wong R, Chhieng D, Levy GH, Gettinger SN, Herbst RS, Puchalski JT, Homer RJ, Hui P. Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma. Cancer Cytopathology 2013, 121: 500-507. PMID: 23495083, DOI: 10.1002/cncy.21288.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAnaplastic Lymphoma KinaseBiomarkers, TumorBone NeoplasmsCytodiagnosisDNA, NeoplasmErbB ReceptorsFeasibility StudiesFemaleGene RearrangementHumansIn Situ Hybridization, FluorescenceLiver NeoplasmsLung NeoplasmsMaleMiddle AgedMutationNeoplasm Recurrence, LocalPrognosisProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsReal-Time Polymerase Chain ReactionReceptor Protein-Tyrosine KinasesSoft Tissue NeoplasmsYoung AdultConceptsALK gene rearrangementMetastatic lung adenocarcinomaEGFR mutationsKRAS mutationsMetastatic tumorsEpidermal growth factor receptorLung adenocarcinomaCytological specimensGene rearrangementsMolecular testsMolecular alterationsKirsten rat sarcoma viral oncogene homolog (KRAS) mutationsALK gene rearrangement analysisAnaplastic lymphoma kinase (ALK) gene rearrangementEGFR T790M mutationRat sarcoma viral oncogene homolog mutationsCases of lungT790M mutationImportant therapeutic implicationsFine needle aspiratesGene rearrangement analysisCell block materialGrowth factor receptorRecurrent lungRecurrent adenocarcinoma
2012
Cytoplasmic vacuolization: An under‐recognized cytomorphologic feature in endocrine tumors of the pancreas
Levy GH, Finkelstein A, Harigopal M, Chhieng D, Cai G. Cytoplasmic vacuolization: An under‐recognized cytomorphologic feature in endocrine tumors of the pancreas. Diagnostic Cytopathology 2012, 41: 623-628. PMID: 22807461, DOI: 10.1002/dc.22893.Peer-Reviewed Original ResearchConceptsFine-needle aspirationPancreatic endocrine neoplasmsCytomorphologic featuresDiagnostic pitfallsEndoscopic ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationFine cytoplasmic vacuolesClinicopathologic featuresDiagnostic challengeEndocrine tumorsEndocrine neoplasmsSmall biopsiesAccurate diagnosisImmunocytochemical studyCytoplasmic vacuolesDiagnostic value of K‐ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis
Cai G, Mahooti S, Lipata FM, Chhieng D, Hui P. Diagnostic value of K‐ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis. Cancer Cytopathology 2012, 120: 313-318. PMID: 22367918, DOI: 10.1002/cncy.21188.Peer-Reviewed Original Research
2011
The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patients
Monaco SE, Khalbuss WE, Ustinova E, Liang A, Cai G. The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patients. Diagnostic Cytopathology 2011, 40: 1062-1070. PMID: 21591276, DOI: 10.1002/dc.21733.Peer-Reviewed Original ResearchConceptsSalivary gland-type tumorsMucoepidermoid carcinomaPrimary tumorType tumorsPolymorphous low-grade adenocarcinomaCommon histological subtypeAspiration cytology specimensDiagnosis of ACCSalivary duct carcinomaLow-grade adenocarcinomaMinor salivary glandsCytomorphologic spectrumDuct carcinomaHistological subtypesBasaloid tumorsCystic carcinomaCytomorphologic featuresSoft palateGrade adenocarcinomaDiagnostic pitfallsNasal cavityCytology casesCytology specimensMediastinumTumors