2016
The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer*
Wang Z, Liu N, Shi S, Liu S, Lin H. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer*. Journal Of Biological Chemistry 2016, 291: 10646-10658. PMID: 26957540, PMCID: PMC4865913, DOI: 10.1074/jbc.m116.723239.Peer-Reviewed Original ResearchConceptsP-element-induced wimpy testisPIWI-interacting RNAsPIWI proteinsMDA-MB-231 cellsArgonaute family proteinsGermline developmentDiverse organismsWimpy testisFamily proteinsProteome analysisClass II proteinsPIWIL4Potential therapeutic targetStem cellsProteinMHC class II proteinsMigration abilityRNATherapeutic targetPIWIL4 expressionCancer tissuesBreast cancer tissuesCellsKey roleBiogenesis
2006
MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis
Grivna ST, Pyhtila B, Lin H. MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 13415-13420. PMID: 16938833, PMCID: PMC1569178, DOI: 10.1073/pnas.0605506103.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsSmall RNAsTranslational machineryMRNA cap-binding complexArgonaute family proteinsCap-binding complexPIWI family membersPresence of DicerRound spermatidsSubset of miRNAsCytosolic ribonucleoproteinTranslational repressionGene regulationFamily proteinsSubfamily proteinsCytoplasmic proteinsTarget mRNAsMIWIPosttranscriptional levelPolysomal fractionsPolysome fractionsMature spermGene expressionImportant regulatorSpermiogenesis
2002
Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas
Qiao D, Zeeman AM, Deng W, Looijenga LH, Lin H. Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene 2002, 21: 3988-3999. PMID: 12037681, DOI: 10.1038/sj.onc.1205505.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceArgonaute ProteinsBlotting, NorthernChildChromosome MappingChromosomes, Human, Pair 12Cloning, MolecularDNA PrimersDNA, ComplementaryDrosophila ProteinsFormazansGene LibraryHumansImmunoenzyme TechniquesIn Situ HybridizationMaleMolecular Sequence DataPolymerase Chain ReactionProteinsRNA, MessengerRNA-Induced Silencing ComplexSeminomaSequence Homology, Amino AcidTeratomaTesticular NeoplasmsTetrazolium SaltsConceptsGene familyPiwi gene familyHuman membersGerm cellsMolecular characterizationPiwi family genesPIWI family proteinsEnhanced expressionEmbryonic germ cellsGerm cell phenotypeGerm cell characteristicsGerm cell proliferationStage-dependent patternDiverse organismsDrosophila melanogasterC. elegansGermline cellsGenomic regionsFamily genesFamily proteinsSignificant homologySame precursor cellRNA interferenceChromosomal regionsKb mRNA