2007
Precancerous Stem Cells Have the Potential for both Benign and Malignant Differentiation
Chen L, Shen R, Ye Y, Pu XA, Liu X, Duan W, Wen J, Zimmerer J, Wang Y, Liu Y, Lasky LC, Heerema NA, Perrotti D, Ozato K, Kuramochi-Miyagawa S, Nakano T, Yates AJ, Carson WE, Lin H, Barsky SH, Gao JX. Precancerous Stem Cells Have the Potential for both Benign and Malignant Differentiation. PLOS ONE 2007, 2: e293. PMID: 17356702, PMCID: PMC1808425, DOI: 10.1371/journal.pone.0000293.Peer-Reviewed Original ResearchConceptsCancer stem cellsMalignant differentiationPrecancerous stem cellsStem cellsImmunocompetent miceImmunodeficient miceSolid cancersSolid tumorsTherapy of cancerC-kitNovel targetCancerEarly detectionCancer cellsSca-1Lineage markersTissue cellsMicePCSCsCellsSingle cloneDifferentiationTherapyTumorsPrevention
2006
Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis
Wang Z, Lin H. Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis. Developmental Biology 2006, 302: 160-168. PMID: 17067567, PMCID: PMC1904479, DOI: 10.1016/j.ydbio.2006.09.016.Peer-Reviewed Original ResearchConceptsBruno response elementCystoblast differentiationTranslational repressionElectrophoresis mobility shift assaysGermline stem cellsPotential mRNA targetsMobility shift assaysStem cell progenySex-lethalDrosophila ovaryDrosophila oogenesisMutant phenotypeBioinformatics approachMRNA targetsShift assaysType RNACDNA constructsUntranslated regionCell progenyResponse elementStem cellsNovel targetDifferentiationRepressionMS11