2003
Screens for piwi Suppressors in Drosophila Identify Dosage-Dependent Regulators of Germline Stem Cell Division
Smulders-Srinivasan TK, Lin H. Screens for piwi Suppressors in Drosophila Identify Dosage-Dependent Regulators of Germline Stem Cell Division. Genetics 2003, 165: 1971-1991. PMID: 14704180, PMCID: PMC1462913, DOI: 10.1093/genetics/165.4.1971.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArgonaute ProteinsCell DivisionChromosomesDrosophilaDrosophila ProteinsFemaleGene DosageGene Expression Regulation, DevelopmentalGenes, LethalGerm CellsInfertility, MaleMaleProteinsRNA-Induced Silencing ComplexStem CellsSuppression, GeneticTranscription, GeneticZygoteConceptsStem cell divisionGermline stem cell divisionGenes/sequencesCell divisionFemale-specific lethalityDosage-dependent regulatorGermline stem cellsStem cell maintenanceDrosophila third chromosomeFamily of genesDosage-sensitive mannerPiwi mutantsZygotic functionMutant backgroundPiwi genesThird chromosomeMale germlineMale sterilitySuppressor mutationsSuch genesCell maintenanceGenetic regulationPlant kingdomTranscription factorsTranscriptional level
2002
miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis
Deng W, Lin H. miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis. Developmental Cell 2002, 2: 819-830. PMID: 12062093, DOI: 10.1016/s1534-5807(02)00165-x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsArgonaute ProteinsChromosome MappingCloning, MolecularCyclic AMP Response Element ModulatorCytoplasmDNA-Binding ProteinsGene Expression RegulationInfertility, MaleLIM Domain ProteinsMaleMiceMice, KnockoutMolecular Sequence DataProtein IsoformsProteinsRepressor ProteinsRNA, MessengerSpermatogenesisTestisTranscription FactorsConceptsTarget genesPiwi family genesCytoplasmic protein essentialRound spermatid stageDiverse organismsPiwi genesTranslational regulationFamily genesProtein essentialCytoplasmic proteinsMaster regulatorMurine homologMIWIGenesSpermatid stageStem cellsMRNASpermiogenesisCREMSpermatogenesisSpermatogenic arrestPiwiHomologEncodesCloning