2022
An update on ductal plate malformations and fibropolycystic diseases of the liver
Mirza H, Besse W, Somlo S, Weinreb J, Kenney B, Jain D. An update on ductal plate malformations and fibropolycystic diseases of the liver. Human Pathology 2022, 132: 102-113. PMID: 35777701, DOI: 10.1016/j.humpath.2022.06.022.Peer-Reviewed Original ResearchConceptsDuctal plate malformationLiver diseaseAdult polycystic liver diseaseAutosomal dominant polycystic kidneyFibropolycystic liver diseaseIsolated liver involvementCongenital hepatic fibrosisPolycystic liver diseaseVon Meyenburg complexesGenetic underpinningsMultiple clinical phenotypesFibropolycystic diseasePortal hypertensionCaroli's diseaseLiver involvementLiver cystsMeyenburg complexesHepatic fibrosisFibrocystic lesionsHepatocellular malignanciesCyst enlargementAbnormal organ developmentPolycystic kidneysAnimal modelsHepatocellular malignancy
2012
Blastocystis–Host Interactions: Insights from In Vitro Model Systems
Tan K, Mirza H. Blastocystis–Host Interactions: Insights from In Vitro Model Systems. Parasitology Research Monographs 2012, 4: 51-63. DOI: 10.1007/978-3-642-32738-4_4.ChaptersIntra-subtype variationIntestinal epithelial cell lineHost immune responseProinflammatory cytokinesEpithelial cell lineINOS productionImmune responseBarrier compromiseVitro model systemAnimal modelsClinical relevanceBlastocystis subtypesCell linesPathogenesisVariety of effectsCell deathBlastocystisInsert systemParasitesCytokinesSubtypesImmunoglobulinPathobiology
2008
Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity
Mirza H, Tan KS. Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity. Parasitology Research 2008, 104: 355-361. PMID: 18846388, DOI: 10.1007/s00436-008-1203-1.Peer-Reviewed Original ResearchConceptsCysteine protease activityIntra-subtype variationRodent isolatesIL-8 responseColonic epithelial cellsHuman secretory IgAClinical studiesSecretory IgAAnimal modelsNon-virulent strainsProtease activityBlastocystis subtypesCysteine proteasesEpithelial cellsGiardia intestinalisCellular mechanismsZoonotic potentialBlastocystisEntamoeba histolyticaAvian isolatesPresent studyIsolatesSame isolatesParasitesIgA