2011
Plasma Markers for Identifying Patients with Metastatic Melanoma
Kluger HM, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, Sznol M, Ariyan S, Molinaro A, Halaban R. Plasma Markers for Identifying Patients with Metastatic Melanoma. Clinical Cancer Research 2011, 17: 2417-2425. PMID: 21487066, PMCID: PMC3415234, DOI: 10.1158/1078-0432.ccr-10-2402.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntigens, CDBiomarkers, TumorCell Adhesion MoleculesEnzyme-Linked Immunosorbent AssayExtracellular Matrix ProteinsFemaleGlycoproteinsGrowth Differentiation Factor 15HumansIntercellular Adhesion Molecule-1L-Lactate DehydrogenaseMaleMelanomaMiddle AgedNeoplasm MetastasisNeoplasm ProteinsNeoplasm Recurrence, LocalNeoplasm StagingNerve Growth FactorsPrognosisReproducibility of ResultsS100 Calcium Binding Protein beta SubunitS100 ProteinsSensitivity and SpecificityTissue Inhibitor of Metalloproteinase-1ConceptsGenome-wide gene expression dataGene expression dataHigh expression levelsLevels of proteinExpression dataExpression levelsProteinMelanoma cellsStage I/II diseaseEqual-sized trainingMarkersGenesDisease recurrencePlasma markersMetastatic melanomaTIMP-1Lactate dehydrogenaseCEACAMsStage I/II patientsDehydrogenaseOsteopontinStage IV diseaseStage IV patientsMetastatic melanoma patientsGender-matched patients
2008
Assessing Expression of Apoptotic Markers Using Large Cohort Tissue Microarrays
Pick E, McCarthy MM, Kluger HM. Assessing Expression of Apoptotic Markers Using Large Cohort Tissue Microarrays. Methods In Molecular Biology 2008, 414: 83-93. PMID: 18175814, DOI: 10.1007/978-1-59745-339-4_8.Peer-Reviewed Original ResearchConceptsLarge cohortApoptotic markersParaffin-embedded specimensHundreds of patientsAnti-apoptotic elementsTissue microarray technologySitu protein expressionApoptotic marker expressionTissue microarrayMarker expressionBenign cellsImmunohistochemistryProtein expressionExtrinsic pathwayExpression levelsCohortMarkersExpressionCellsPatients