2022
Coupled fibromodulin and SOX2 signaling as a critical regulator of metastatic outgrowth in melanoma
Oria VO, Zhang H, Zito CR, Rane CK, Ma XY, Provance OK, Tran TT, Adeniran A, Kluger Y, Sznol M, Bosenberg MW, Kluger HM, Jilaveanu LB. Coupled fibromodulin and SOX2 signaling as a critical regulator of metastatic outgrowth in melanoma. Cellular And Molecular Life Sciences 2022, 79: 377. PMID: 35737114, PMCID: PMC9226089, DOI: 10.1007/s00018-022-04364-5.Peer-Reviewed Original ResearchConceptsTumor suppressor Hippo pathwayNovel regulatory mechanismTumor vasculogenic mimicryMetastatic outgrowthExtracellular matrix componentsHippo pathwayRegulatory mechanismsMolecular eventsTumor-stroma interactionsCritical regulatorMetastatic competenceProgenitor markersProliferative stateFunctional roleFunctional studiesSOX2Vasculogenic mimicryDistinct phenotypesMatrix componentsEarly developmentFmodHigh expressionCritical processOutgrowthImportant role
2004
cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model
Kluger HM, Kluger Y, Gilmore-Hebert M, DiVito K, Chang JT, Rodov S, Mironenko O, Kacinski BM, Perkins AS, Sapi E. cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model. Laboratory Investigation 2004, 84: 320-331. PMID: 14767486, DOI: 10.1038/labinvest.3700044.Peer-Reviewed Original ResearchConceptsAutophosphorylation sitesHC11 mammary epithelial cellsMAP kinase phosphatase-1SNARE protein Ykt6Macrophage colony-stimulating factor receptorK cDNA microarrayColony-stimulating factor receptorCDNA microarray analysisKinase phosphatase-1Effects of mutationsMammary epithelial cellsTransmembrane tyrosine kinase receptorTyrosine kinase receptorsPhosphatase 1HC11 cellsCDNA microarrayTumorigenic phenotypeChaperonin 10Gene expressionFms oncogeneMicroarray analysisInvasive phenotypeMetastatic competenceKinase receptorsVivo tumorigenesis