2016
Downregulating FUK to Get Unstuck: Altered Fucosylation in Melanoma Promotes Tumor Development and Metastasis
Lau E, Feng Y, Claps G, Fukuda M, Perlina A, Donn D, Jilaveanu L, Kluger H, Freeze H, Ronai Z. Downregulating FUK to Get Unstuck: Altered Fucosylation in Melanoma Promotes Tumor Development and Metastasis. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.620.2.Peer-Reviewed Original ResearchActivating Transcription Factor 2Fucose salvage pathwayUpstream regulatory kinaseProtein kinase C epsilonTumor microarray analysisGDP-L-fucoseHuman melanoma specimensTranscription factor 2Cellular fucosylationRegulatory kinasesPrimary melanocytesGenetic manipulationMicroarray analysisMelanoma cell linesC epsilonSalvage pathwayPromotes tumor developmentCellular adhesionMelanoma developmentFactor 2Cell linesMelanoma specimensCell populationsTumor developmentFucosylation
2015
The transcription factor ATF2 promotes melanoma metastasis by suppressing protein fucosylation
Lau E, Feng Y, Claps G, Fukuda MN, Perlina A, Donn D, Jilaveanu L, Kluger H, Freeze HH, Ronai ZA. The transcription factor ATF2 promotes melanoma metastasis by suppressing protein fucosylation. Science Signaling 2015, 8: ra124. PMID: 26645581, PMCID: PMC4818095, DOI: 10.1126/scisignal.aac6479.Peer-Reviewed Original ResearchConceptsProtein fucosylationFucose salvage pathwayTranscription factor ATF2Tumor microarray analysisProtein kinase CεTranscription factor 2Human melanoma specimensTranscriptional repressionPrimary melanoma growthPrimary melanocytesGenetic manipulationActive ATF2Cell motilityElucidation of mechanismsMicroarray analysisSalvage pathwayATF2Cell adhesionHigh abundanceCellular adhesionReduced motilityInvasive behaviorCell linesFactor 2Melanoma specimens
2008
Suppressor role of activating transcription factor 2 (ATF2) in skin cancer
Bhoumik A, Fichtman B, DeRossi C, Breitwieser W, Kluger HM, Davis S, Subtil A, Meltzer P, Krajewski S, Jones N, Ronai Z. Suppressor role of activating transcription factor 2 (ATF2) in skin cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 1674-1679. PMID: 18227516, PMCID: PMC2234203, DOI: 10.1073/pnas.0706057105.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneActivating Transcription Factor 2AnimalsApoptosisBeta CateninCarcinogensCell ProliferationCyclin D1DNAEpidermisKeratinocytesMiceMice, KnockoutPapillomaPresenilin-1Proto-Oncogene Proteins c-mybReceptor, Notch1Skin NeoplasmsTetradecanoylphorbol AcetateTissue Array AnalysisTumor Suppressor ProteinsConceptsSkin tumor formationTranscription factor 2Two-stage skin carcinogenesis protocolTumor formationBasal cell carcinomaSkin carcinogenesis protocolFactor 2K14-Cre miceCell carcinomaCarcinogenesis protocolMouse modelBeta-catenin expressionPapilloma developmentSkin cancerExhibit reduced expressionAnchorage-independent growthNormal skinNotch1 expressionCyclin D1MiceReduced expressionSuppressor roleSuppressor activitySelective expressionBasal layer
2003
Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival.
Berger AJ, Kluger HM, Li N, Kielhorn E, Halaban R, Ronai Z, Rimm DL. Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival. Cancer Research 2003, 63: 8103-7. PMID: 14678960.Peer-Reviewed Original ResearchConceptsATF2 expressionTranscription factor 2Melanoma specimensUseful prognostic markerEarly-stage melanomaWeak cytoplasmic stainingStrong nuclear stainingFactor 2Mean followCutaneous specimensLocalized diseaseOverall survivalIndependent predictorsPreclinical findingsClark levelClinicopathological dataPatient survivalPoor outcomePrognostic valueWorse outcomesPrognostic markerPoor survivalPreclinical modelsClinical significanceImmunohistochemical staining