2006
Age‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tract
Yono M, Foster H, Yoshida M, Ueda S, Weiss R, Latifpour J. Age‐related changes in the properties of α1‐adrenoceptors in the rat genitourinary tract. The FASEB Journal 2006, 20: a254-a254. DOI: 10.1096/fasebj.20.4.a254-a.Peer-Reviewed Original ResearchLower urinary tract symptomsRat genitourinary tractBenign prostatic hyperplasiaΑ1-AR antagonistsAge-related changesMonth old ratsGenitourinary tractOld ratsBladder baseBladder domeDorsolateral prostateVentral prostateUrinary tract symptomsMaximum contractile responseLow testosterone levelsRadioligand receptor bindingSignificant age-dependent differencesReal-time RT-PCR techniqueAge-dependent differencesHigher body weightRT-PCR techniqueTract symptomsContractile responseOlder patientsSubtype mRNAs
2000
Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome
Saito M, Wada Y, Ikeda K, Wang Z, Smith S, Foster H, Nishi K, Weiss R, Latifpour J. Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome. European Journal Of Pharmacology 2000, 387: 253-263. PMID: 10650170, DOI: 10.1016/s0014-2999(99)00753-0.Peer-Reviewed Original ResearchConceptsRat bladder domeEndothelin receptorsBladder domeInsulin treatmentReceptor subtypesFunctional endothelin receptorsMammalian urinary tractEndothelin receptor subtypesInduction of diabetesAge-matched controlsReceptor alterationsExperimental diabetesUrinary tractPharmacological characterizationPharmacological profileMuscular layerMRNA upregulationAutoradiographic studyTranscription-polymerase chain reaction dataReceptorsExpression levelsDiabetesTissue componentsSubtypesTreatment