Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment
Saito M, Wado Y, Ikeda K, Wang Z, Foster H, Smith S, Weiss R, Latifpour J. Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment. Molecular And Cellular Biochemistry 2000, 210: 1-11. PMID: 10976752, DOI: 10.1023/a:1007041909477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalEndothelin Receptor AntagonistsEndothelin-1InsulinIodine RadioisotopesMaleOrgan SizeProstateProtein IsoformsRadioligand AssayRandom AllocationRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTestosteroneUp-RegulationConceptsInduction of diabetesET receptorsReverse transcription-polymerase chain reactionRat prostateInsulin treatmentDiabetic animalsReceptor subtypesDiabetes-induced upregulationET receptor densityEndothelin receptor subtypesET receptor subtypesSTZ-injected ratsSerum testosterone levelsRadioligand receptor bindingDiabetic rat prostateTranscription-polymerase chain reactionDiabetic ratsETB receptorsSmaller prostatesEndothelin receptorsProstatic stromaTestosterone levelsReceptor densityPharmacological profileAutoradiographic studyGene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome
Saito M, Wada Y, Ikeda K, Wang Z, Smith S, Foster H, Nishi K, Weiss R, Latifpour J. Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome. European Journal Of Pharmacology 2000, 387: 253-263. PMID: 10650170, DOI: 10.1016/s0014-2999(99)00753-0.Peer-Reviewed Original ResearchConceptsRat bladder domeEndothelin receptorsBladder domeInsulin treatmentReceptor subtypesFunctional endothelin receptorsMammalian urinary tractEndothelin receptor subtypesInduction of diabetesAge-matched controlsReceptor alterationsExperimental diabetesUrinary tractPharmacological characterizationPharmacological profileMuscular layerMRNA upregulationAutoradiographic studyTranscription-polymerase chain reaction dataReceptorsExpression levelsDiabetesTissue componentsSubtypesTreatment