2000
Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment
Saito M, Wado Y, Ikeda K, Wang Z, Foster H, Smith S, Weiss R, Latifpour J. Expression of endothelin receptor subtypes and their messenger RNAs in diabetic rat prostate: Effect of insulin treatment. Molecular And Cellular Biochemistry 2000, 210: 1-11. PMID: 10976752, DOI: 10.1023/a:1007041909477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalEndothelin Receptor AntagonistsEndothelin-1InsulinIodine RadioisotopesMaleOrgan SizeProstateProtein IsoformsRadioligand AssayRandom AllocationRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTestosteroneUp-RegulationConceptsInduction of diabetesET receptorsReverse transcription-polymerase chain reactionRat prostateInsulin treatmentDiabetic animalsReceptor subtypesDiabetes-induced upregulationET receptor densityEndothelin receptor subtypesET receptor subtypesSTZ-injected ratsSerum testosterone levelsRadioligand receptor bindingDiabetic rat prostateTranscription-polymerase chain reactionDiabetic ratsETB receptorsSmaller prostatesEndothelin receptorsProstatic stromaTestosterone levelsReceptor densityPharmacological profileAutoradiographic studyGene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome
Saito M, Wada Y, Ikeda K, Wang Z, Smith S, Foster H, Nishi K, Weiss R, Latifpour J. Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome. European Journal Of Pharmacology 2000, 387: 253-263. PMID: 10650170, DOI: 10.1016/s0014-2999(99)00753-0.Peer-Reviewed Original ResearchConceptsRat bladder domeEndothelin receptorsBladder domeInsulin treatmentReceptor subtypesFunctional endothelin receptorsMammalian urinary tractEndothelin receptor subtypesInduction of diabetesAge-matched controlsReceptor alterationsExperimental diabetesUrinary tractPharmacological characterizationPharmacological profileMuscular layerMRNA upregulationAutoradiographic studyTranscription-polymerase chain reaction dataReceptorsExpression levelsDiabetesTissue componentsSubtypesTreatment
1998
CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA
NISHI K, LATIFPOUR J, SAITO M, FOSTER H, YOSHIDA M, WEISS R. CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA. Journal Of Urology 1998, 160: 196-205. PMID: 9628650, DOI: 10.1016/s0022-5347(01)63090-8.Peer-Reviewed Original ResearchConceptsAlpha1 adrenoceptorsRabbit urethraMale rabbit urethraSelective alpha1-adrenoceptor antagonistAnti-alpha smooth muscle actinAlpha1-adrenoceptor antagonistRabbit urethral smooth muscleUrethral smooth muscleRadioligand receptor bindingSmooth muscle actinSmooth muscle fibersLight microscopic autoradiographySingle high-affinity binding siteAdrenoceptor antagonistBMY 7378Distal urethraWB 4101Immunohistochemical studyPharmacological characterizationSmooth musclePharmacological profileAdrenoceptorsUrethraMuscle actinHigh-affinity binding sitesCHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA
NISHI K, LATIFPOUR J, SAITO M, FOSTER H, YOSHIDA M, WEISS R. CHARACTERIZATION, LOCALIZATION AND DISTRIBUTION OF alpha1 ADRENOCEPTOR SUBTYPE IN MALE RABBIT URETHRA. Journal Of Urology 1998, 160: 196-205.. DOI: 10.1097/00005392-199807000-00084.Peer-Reviewed Original ResearchAlpha1 adrenoceptorsMale rabbit urethraRabbit urethraSelective alpha1-adrenoceptor antagonistAnti-alpha smooth muscle actinAlpha1-adrenoceptor antagonistRadioligand receptor bindingSmooth muscle actinLight microscopic autoradiographySingle high-affinity binding siteAdrenoceptor antagonistPharmacological profileAbstract PurposeMuscle actinHigh-affinity binding sitesUrethraSubtype specificityAdrenoceptorsAffinity binding sitesReceptor bindingActin antibodyMicroscopic autoradiographySaturation experimentsInhibition experimentsRank orderProperties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes
Nishi K, Wada Y, Saito M, Foster H, Weiss R, Latifpour J. Properties of Alpha-1-Adrenergic Receptors in the Rat Prostate: Effect of Experimental Diabetes. Urologia Internationalis 1998, 61: 147-153. PMID: 9933834, DOI: 10.1159/000030311.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AntagonistsAnalysis of VarianceAnimalsBinding SitesCulture TechniquesDiabetes Mellitus, ExperimentalDisease Models, AnimalDown-RegulationLinear ModelsMaleProstateRatsRats, Sprague-DawleyReceptors, Adrenergic, alphaReference ValuesSpleenStreptozocinSubmandibular GlandVas DeferensConceptsRat prostateAlpha-1 adrenergic receptorsInduction of diabetesSTZ-induced diabetesWeeks of streptozotocinDiabetic rat prostateSimilar pharmacological profileReceptor subtype specificityExperimental diabetesAlpha1A-subtypeRat submaxillary glandReceptor-binding experimentsRat vasPharmacological profileDiabetesProstateSubtype specificityPharmacological propertiesKi valuesSubmaxillary glandRat spleenPrazosinWB4101BMY7378Spiperone
1996
Effect of experimental diabetes on rat prostate endothelin receptors
Saito M, Nishi K, Foster H, Weiss R, Latifpour J. Effect of experimental diabetes on rat prostate endothelin receptors. European Journal Of Pharmacology 1996, 310: 197-200. PMID: 8884217, DOI: 10.1016/0014-2999(96)00422-0.Peer-Reviewed Original Research