Inherited Variants in Mitochondrial Biogenesis Genes May Influence Epithelial Ovarian Cancer Risk
Permuth-Wey J, Chen YA, Tsai YY, Chen Z, Qu X, Lancaster JM, Stockwell H, Dagne G, Iversen E, Risch H, Barnholtz-Sloan J, Cunningham JM, Vierkant RA, Fridley BL, Sutphen R, McLaughlin J, Narod SA, Goode EL, Schildkraut JM, Fenstermacher D, Phelan CM, Sellers TA. Inherited Variants in Mitochondrial Biogenesis Genes May Influence Epithelial Ovarian Cancer Risk. Cancer Epidemiology Biomarkers & Prevention 2011, 20: 1131-1145. PMID: 21447778, PMCID: PMC3111851, DOI: 10.1158/1055-9965.epi-10-1224.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, Clear CellAdenocarcinoma, MucinousBasic-Leucine Zipper Transcription FactorsCalcium-Calmodulin-Dependent Protein Kinase Type 2Case-Control StudiesCystadenocarcinoma, SerousDNA, MitochondrialEndometrial NeoplasmsFemaleGenes, MitochondrialGenotypeHeat-Shock ProteinsHumansMiddle AgedMitochondrial ProteinsNF-E2-Related Factor 2Nuclear Respiratory Factor 1Ovarian NeoplasmsOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPolymorphism, Single NucleotideReceptors, EstrogenRisk FactorsTranscription FactorsConceptsMitochondrial biogenesis genesSingle nucleotide polymorphismsBiogenesis genesMitochondrial biogenesisSNP-level associationsOxidative phosphorylation pathwayEpithelial ovarian cancer susceptibilityMitochondrial-related genesGenes/regionsMitochondrial genomeOxidative stressPhosphorylation pathwayMTERFsSNP levelEOC susceptibilityGenesOvarian cancer susceptibilityNucleotide polymorphismsBiogenesisCancer susceptibilitySteroid hormone metabolismHormone metabolismEOC riskComplex mechanismsNongenetic factorsLIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Permuth-Wey J, Kim D, Tsai YY, Lin HY, Chen YA, Barnholtz-Sloan J, Birrer MJ, Bloom G, Chanock SJ, Chen Z, Cramer DW, Cunningham JM, Dagne G, Ebbert-Syfrett J, Fenstermacher D, Fridley BL, Garcia-Closas M, Gayther SA, Ge W, Gentry-Maharaj A, Gonzalez-Bosquet J, Goode EL, Iversen E, Jim H, Kong W, McLaughlin J, Menon U, Monteiro AN, Narod SA, Pharoah PD, Phelan CM, Qu X, Ramus SJ, Risch H, Schildkraut JM, Song H, Stockwell H, Sutphen R, Terry KL, Tyrer J, Vierkant RA, Wentzensen N, Lancaster JM, Cheng JQ, Sellers TA, Consortium O. LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer. Cancer Research 2011, 71: 3896-3903. PMID: 21482675, PMCID: PMC3107389, DOI: 10.1158/0008-5472.can-10-4167.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAllelesCarcinoma, Ovarian EpithelialCase-Control StudiesCell Line, TumorDNA, NeoplasmDNA-Binding ProteinsFemaleGenetic Predisposition to DiseaseHumansMicroRNAsMiddle AgedNeoplasms, Glandular and EpithelialOvarian NeoplasmsPolymorphism, Single NucleotideRNA-Binding ProteinsTransfectionConceptsMiRNA biogenesis genesSingle nucleotide polymorphismsBiogenesis genesPutative transcription factorLuciferase reporter assaysMicroRNA biogenesisTranscription factorsPromoter regionTumor suppressorReporter assaysQuantitative RT-PCREOC susceptibilityGenesNucleotide polymorphismsLIN28B overexpressionLIN28B expressionLIN28B geneInfluence susceptibilityRT-PCRExpressionEpithelial ovarian cancerBiogenesisDroshaOvarian cancerFMR1