2016
Frequency of germline PALB2 mutations among women with epithelial ovarian cancer
Kotsopoulos J, Sopik V, Rosen B, Fan I, McLaughlin JR, Risch H, Sun P, Narod SA, Akbari MR. Frequency of germline PALB2 mutations among women with epithelial ovarian cancer. Familial Cancer 2016, 16: 29-34. PMID: 27631815, DOI: 10.1007/s10689-016-9919-z.Peer-Reviewed Original ResearchConceptsGermline PALB2 mutationsPALB2 mutationsOvarian cancerEpithelial ovarian cancer patientsYear of diagnosisEpithelial ovarian cancerOvarian cancer patientsOvarian cancer riskMean ageCancer patientsControl subjectsNational HeartMedical recordsClinical recommendationsSurvival statusCancer riskClinical informationUnselected populationClinical relevanceBRCA2 genesGermline mutationsCancerFurther studiesPatientsPrevalence
2014
Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer
Neale RE, Clark PJ, Fawcett J, Fritschi L, Nagler BN, Risch HA, Walters RJ, Crawford WJ, Webb PM, Whiteman DC, Buchanan DD. Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer. Cancer Epidemiology 2014, 38: 576-582. PMID: 25201440, DOI: 10.1016/j.canep.2014.08.006.Peer-Reviewed Original ResearchConceptsPancreatic cancerWhite blood cell DNABlood cell DNAOdds ratioPresence of metastasesCancer-related deathPancreatic cancer casesHealthy unrelated controlsEarly diseaseCell DNALeading causeCancer casesWBC DNADNA repetitive elementsBlood collectionCancerConfidence intervalsUnrelated controlsMethylation scoreFurther studiesAssociationMarkersDeathPCR assaysQuantitative PCR assays
1997
Perineal talc exposure and risk of ovarian carcinoma
Chang S, Risch H. Perineal talc exposure and risk of ovarian carcinoma. Cancer 1997, 79: 2396-2401. PMID: 9191529, DOI: 10.1002/(sici)1097-0142(19970615)79:12<2396::aid-cncr15>3.0.co;2-m.Peer-Reviewed Original ResearchConceptsOvarian carcinomaTalc exposureFrequency of exposureUnconditional logistic regression methodsTalcum powder useInvasive ovarian carcinomasBorderline significant associationPerineal talc exposureBorderline carcinomaMenstrual historyInvasive carcinomaCarcinoma typesEpidemiologic studiesEpidemiologic investigationsCarcinomaSignificant associationPowder useHistologic sectionsLogistic regression methodRole of talcSignificant riskFurther studiesOnly riskRiskPerineum