2016
Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study
Childs EJ, Chaffee KG, Gallinger S, Syngal S, Schwartz AG, Cote ML, Bondy ML, Hruban RH, Chanock SJ, Hoover RN, Fuchs CS, Rider DN, Amundadottir LT, Stolzenberg-Solomon R, Wolpin BM, Risch HA, Goggins MG, Petersen GM, Klein AP. Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study. Cancer Epidemiology Biomarkers & Prevention 2016, 25: 1185-1191. PMID: 27197284, PMCID: PMC5321211, DOI: 10.1158/1055-9965.epi-15-1217.Peer-Reviewed Original ResearchConceptsHigh-risk populationPancreatic cancerEarly onset pancreatic cancerPancreatic cancer familiesHigh-risk patientsMagnitude of associationHigh-penetrance genesGenetic variantsPancreatic cancer susceptibilityUnselected patientsFamily historyProstate cancerColon cancerCommon genetic variantsCancerCancer familiesLogistic regressionCancer susceptibilityCancer susceptibility lociPatientsCancer lociOvarianCommon variantsBreastRisk
1998
Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia
Chow W, Blot W, Vaughan T, Risch H, Gammon M, Stanford J, Dubrow R, Schoenberg J, Mayne S, Farrow D, Ahsan H, West A, Rotterdam H, Niwa S, Fraumeni J. Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia. Journal Of The National Cancer Institute 1998, 90: 150-155. PMID: 9450576, DOI: 10.1093/jnci/90.2.150.Peer-Reviewed Original ResearchConceptsBody mass indexEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaSquamous cell carcinomaGastric cardia adenocarcinomaAdult body mass indexOdds ratioCell carcinomaGastric adenocarcinomaCardia adenocarcinomaGastric cardiaCase patientsMass indexEsophageal adenocarcinomaPopulation-based case-control studyAge groupsRisk of adenocarcinomaAdenocarcinoma of esophagusAnthropometric risk factorsPrevalence of obesityHealthy control subjectsCase-control studyYounger age groupsMagnitude of associationUnited States population