Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
Permuth-Wey J, Lawrenson K, Shen HC, Velkova A, Tyrer JP, Chen Z, Lin HY, Ann Chen Y, Tsai YY, Qu X, Ramus SJ, Karevan R, Lee J, Lee N, Larson MC, Aben KK, Anton-Culver H, Antonenkova N, Antoniou AC, Armasu SM, Bacot F, Baglietto L, Bandera E, Barnholtz-Sloan J, Beckmann M, Birrer M, Bloom G, Bogdanova N, Brinton L, Brooks-Wilson A, Brown R, Butzow R, Cai Q, Campbell I, Chang-Claude J, Chanock S, Chenevix-Trench G, Cheng J, Cicek M, Coetzee G, Cook L, Couch F, Cramer D, Cunningham J, Dansonka-Mieszkowska A, Despierre E, Doherty J, Dörk T, du Bois A, Dürst M, Easton D, Eccles D, Edwards R, Ekici A, Fasching P, Fenstermacher D, Flanagan J, Garcia-Closas M, Gentry-Maharaj A, Giles G, Glasspool R, Gonzalez-Bosquet J, Goodman M, Gore M, Górski B, Gronwald J, Hall P, Halle M, Harter P, Heitz F, Hillemanns P, Hoatlin M, Høgdall C, Høgdall E, Hosono S, Jakubowska A, Jensen A, Jim H, Kalli K, Karlan B, Kaye S, Kelemen L, Kiemeney L, Kikkawa F, Konecny G, Krakstad C, Krüger Kjaer S, Kupryjanczyk J, Lambrechts D, Lambrechts S, Lancaster J, Le N, Leminen A, Levine D, Liang D, Kiong Lim B, Lin J, Lissowska J, Lu K, Lubiński J, Lurie G, Massuger L, Matsuo K, McGuire V, McLaughlin J, Menon U, Modugno F, Moysich K, Nakanishi T, Narod S, Nedergaard L, Ness R, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson S, Orlow I, Paul J, Pearce C, Pejovic T, Pelttari L, Pike M, Poole E, Raska P, Renner S, Risch H, Rodriguez-Rodriguez L, Anne Rossing M, Rudolph A, Runnebaum I, Rzepecka I, Salvesen H, Schwaab I, Severi G, Shridhar V, Shu X, Shvetsov Y, Sieh W, Song H, Southey M, Spiewankiewicz B, Stram D, Sutphen R, Teo S, Terry K, Tessier D, Thompson P, Tworoger S, van Altena A, Vergote I, Vierkant R, Vincent D, Vitonis A, Wang-Gohrke S, Palmieri Weber R, Wentzensen N, Whittemore A, Wik E, Wilkens L, Winterhoff B, Ling Woo Y, Wu A, Xiang Y, Yang H, Zheng W, Ziogas A, Zulkifli F, Phelan C, Iversen E, Schildkraut J, Berchuck A, Fridley B, Goode E, Pharoah P, Monteiro A, Sellers T, Gayther S. Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nature Communications 2013, 4: 1627. PMID: 23535648, PMCID: PMC3709460, DOI: 10.1038/ncomms2613.Peer-Reviewed Original ResearchConceptsOvarian cancer susceptibility lociMiRNA-related single nucleotide polymorphismsEOC susceptibilityIntegrated molecular analysisCommon susceptibility variantsCancer susceptibility lociEOC susceptibility genesCollaborative Oncological Gene-environment StudyInversion polymorphismSingle nucleotide polymorphismsUntranslated regionHeritable componentMolecular characterizationSusceptibility lociAdditional genotypingFunctional targetSusceptibility variantsSusceptibility genesMolecular analysisStrong signalGene-environment studiesPolymorphismARHGAP27PLEKHM1MiRSNPsGWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis J, Dicks E, Aben K, Anton-Culver H, Antonenkova N, Armasu S, Baglietto L, Bandera E, Beckmann M, Birrer M, Bloom G, Bogdanova N, Brenton J, Brinton L, Brooks-Wilson A, Brown R, Butzow R, Campbell I, Carney M, Carvalho R, Chang-Claude J, Chen Y, Chen Z, Chow W, Cicek M, Coetzee G, Cook L, Cramer D, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty J, Dörk T, du Bois A, Dürst M, Eccles D, Edwards R, Ekici A, Fasching P, Fenstermacher D, Flanagan J, Gao Y, Garcia-Closas M, Gentry-Maharaj A, Giles G, Gjyshi A, Gore M, Gronwald J, Guo Q, Halle M, Harter P, Hein A, Heitz F, Hillemanns P, Hoatlin M, Høgdall E, Høgdall C, Hosono S, Jakubowska A, Jensen A, Kalli K, Karlan B, Kelemen L, Kiemeney L, Kjaer S, Konecny G, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le N, Lee N, Lee J, Leminen A, Lim B, Lissowska J, Lubiński J, Lundvall L, Lurie G, Massuger L, Matsuo K, McGuire V, McLaughlin J, Menon U, Modugno F, Moysich K, Nakanishi T, Narod S, Ness R, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson S, Orlow I, Paul J, Pejovic T, Pelttari L, Permuth-Wey J, Pike M, Poole E, Qu X, Risch H, Rodriguez-Rodriguez L, Rossing M, Rudolph A, Runnebaum I, Rzepecka I, Salvesen H, Schwaab I, Severi G, Shen H, Shridhar V, Shu X, Sieh W, Southey M, Spellman P, Tajima K, Teo S, Terry K, Thompson P, Timorek A, Tworoger S, van Altena A, van den Berg D, Vergote I, Vierkant R, Vitonis A, Wang-Gohrke S, Wentzensen N, Whittemore A, Wik E, Winterhoff B, Woo Y, Wu A, Yang H, Zheng W, Ziogas A, Zulkifli F, Goodman M, Hall P, Easton D, Pearce C, Berchuck A, Chenevix-Trench G, Iversen E, Monteiro A, Gayther S, Schildkraut J, Sellers T. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nature Genetics 2013, 45: 362-370. PMID: 23535730, PMCID: PMC3693183, DOI: 10.1038/ng.2564.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCooperative BehaviorCystadenocarcinoma, SerousFemaleGene-Environment InteractionGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMeta-Analysis as TopicNeoplasm InvasivenessOvarian NeoplasmsPolymorphism, Single NucleotideRisk FactorsConceptsOvarian cancer susceptibility lociSusceptibility lociGenome-wide association studiesNew susceptibility lociCancer susceptibility lociRegulatory regionsAssociation studiesMolecular analysisLociDisease mechanismsOvarian Cancer Association ConsortiumOvarian cancerGWASGenesEpithelial ovarian cancerConsortium