2016
Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett’s Esophagus
Dai JY, de Dieu Tapsoba J, Buas MF, Consortium T, Chow W, Shaheen N, Anderson L, Corley D, Gammon M, Hardie L, Lagergren J, Whiteman D, Risch H, Vaughan T. Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett’s Esophagus. American Journal Of Human Genetics 2016, 99: 352-365. PMID: 27486777, PMCID: PMC4974090, DOI: 10.1016/j.ajhg.2016.06.018.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAge FactorsBarrett EsophagusEsophageal NeoplasmsFemaleGastroesophageal RefluxGene-Environment InteractionGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleModels, GeneticObesityOdds RatioPolymorphism, Single NucleotideReproducibility of ResultsRisk FactorsSample SizeSex FactorsSmokingConceptsBarrett's esophagusEsophageal adenocarcinomaGene-environment interactionsMultiple risk factorsEsophageal Adenocarcinoma ConsortiumEnvironmental exposure dataGenetic variantsGastresophageal refluxTobacco smokingRisk factorsCancer epidemiologyEsophagusExposure dataAdenocarcinomaMultivariate gene-environment interactionsLow statistical powerTesting strategiesGenome-wide significanceSmokingObesityStatistical powerEpidemiologyRefluxRisk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma
McWilliams RR, Maisonneuve P, Bamlet WR, Petersen GM, Li D, Risch HA, Yu H, Fontham ET, Luckett B, Bosetti C, Negri E, La Vecchia C, Talamini R, de Mesquita H, Bracci P, Gallinger S, Neale RE, Lowenfels AB. Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma. Pancreas 2016, 45: 311-316. PMID: 26646264, PMCID: PMC4710562, DOI: 10.1097/mpa.0000000000000392.Peer-Reviewed Original ResearchConceptsEarly onset pancreatic cancerPancreatic cancerAge-dependent effectsRisk factorsFamily historySex-matched control subjectsDiagnosis of PCCase-control studyLogistic regression analysisPC patientsDiabetes mellitusAlcohol intakeControl subjectsOdds ratioPancreatic adenocarcinomaEarly onsetPatientsOlder adultsStrong associationObesitySmokingRegression analysisRiskAssociationComprehensive assessment
2015
Occupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer
Fritschi L, Benke G, Risch HA, Schulte A, Webb PM, Whiteman DC, Fawcett J, Neale RE. Occupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer. Occupational And Environmental Medicine 2015, 72: 678. PMID: 25780030, DOI: 10.1136/oemed-2014-102522.Peer-Reviewed Original ResearchConceptsCase-control studyOccupational exposurePancreatic cancerPopulation-based case-control studyLarge case-control studyLifetime job historiesPancreatic cancer developmentCigarette smokingLifestyle factorsFrequency of exposureLikelihood of exposureAnimal evidenceIncrease riskPancreatic carcinogenCancer developmentN-nitrosaminesOccupational hygienistsCancerSuch exposureJob historyRiskExposureAssociationSmokingSpecific questions
2014
Cigarette smoking and pancreatic cancer risk: More to the story than just pack-years
Schulte A, Pandeya N, Tran B, Fawcett J, Fritschi L, Risch HA, Webb PM, Whiteman DC, Neale RE, Group Q. Cigarette smoking and pancreatic cancer risk: More to the story than just pack-years. European Journal Of Cancer 2014, 50: 997-1003. PMID: 24461200, DOI: 10.1016/j.ejca.2013.12.014.Peer-Reviewed Original ResearchConceptsPancreatic cancer riskCigarette smokingOdds ratioPancreatic adenocarcinomaCancer riskAustralian population-based case-control studyPopulation-based case-control studyLogistic regressionPancreatic cancer patientsConfidence intervalsCase-control studyPancreatic cancer studiesCurrent smokersAlcohol intakeSmoking patternsCancer patientsPancreatic cancerRisk factorsSmoking componentSmokingDisease riskRisk estimatesCancer studiesSmokersAdenocarcinoma
2011
Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)
Bosetti C, Lucenteforte E, Silverman DT, Petersen G, Bracci PM, Ji BT, Negri E, Li D, Risch HA, Olson SH, Gallinger S, Miller AB, Bueno-de-Mesquita HB, Talamini R, Polesel J, Ghadirian P, Baghurst PA, Zatonski W, Fontham E, Bamlet WR, Holly EA, Bertuccio P, Gao YT, Hassan M, Yu H, Kurtz RC, Cotterchio M, Su J, Maisonneuve P, Duell EJ, Boffetta P, La Vecchia C. Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4). Annals Of Oncology 2011, 23: 1880-1888. PMID: 22104574, PMCID: PMC3387822, DOI: 10.1093/annonc/mdr541.Peer-Reviewed Original ResearchConceptsInternational Pancreatic Cancer Case-Control ConsortiumPancreatic Cancer Case-Control ConsortiumCigarette smokingNumber of cigarettesPancreatic cancerOdds ratioStudy-specific odds ratiosLarge pooled analysisYears of smokingDuration of smokingCurrent cigarette smokersCurrent cigarette smokingCase-control studySummary odds ratiosRandom-effects modelDose-response relationshipNever smokersCurrent smokersFormer smokersCigarette smokersCigarette cessationPooled analysisSmokingSmokersCancer
2004
Smoking and ovarian cancer
Halick C, Risch H. Smoking and ovarian cancer. 2004, 511-521. DOI: 10.1093/oso/9780198526872.003.0030.Peer-Reviewed Original Research
1997
Tobacco, Alcohol, and Socioeconomic Status and Adenocarcinomas of the Esophagus and Gastric Cardia
Gammon M, Ahsan H, Schoenberg J, West A, Rotterdam H, Niwa S, Blot W, Risch H, Dubrow R, Mayne S, Vaughan T, Stanford J, Farrow D, Chow W, Fraumeni J. Tobacco, Alcohol, and Socioeconomic Status and Adenocarcinomas of the Esophagus and Gastric Cardia. Journal Of The National Cancer Institute 1997, 89: 1277-1284. PMID: 9293918, DOI: 10.1093/jnci/89.17.1277.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaGastric cardiaSquamous cell carcinomaCell carcinomaGastric adenocarcinomaRisk factorsTumor typesNoncardia gastric adenocarcinomaDuration of smokingCurrent cigarette smokersRisk of esophagealMajor risk factorCase-control studyGastric cardia adenocarcinomaEarly-stage carcinogenesisCigarette smokersHigher ORsControl subjectsIncidence rateSimilar ORsCardia adenocarcinomaEstimates of riskAdenocarcinomaCardiaSmoking
1993
Are Female Smokers at Higher Risk for Lung Cancer than Male Smokers?
Risch H, Howe G, Jain M, Burch J, Holowaty E, Miller A. Are Female Smokers at Higher Risk for Lung Cancer than Male Smokers? American Journal Of Epidemiology 1993, 138: 281-293. PMID: 8395141, DOI: 10.1093/oxfordjournals.aje.a116857.Peer-Reviewed Original ResearchConceptsLung cancerOdds ratioElevated riskGreater smoking cessationHigher elevated riskCase-control studyHigher odds ratioLife-style factorsArea of residenceHistologic groupingsMale smokersFemale smokersCigarette smokingSmoking cessationCancer casesHigh riskCigarette consumptionDetailed questioningLifelong historySmokersTobacco productsCancerDuration of timeMale-female differencesSmoking