2023
Dynamic changes of circulating soluble PD-1/PD-L1 and its association with patient survival in immune checkpoint blockade-treated melanoma
Lu L, Risch E, Halaban R, Zhen P, Bacchiocchi A, Risch H. Dynamic changes of circulating soluble PD-1/PD-L1 and its association with patient survival in immune checkpoint blockade-treated melanoma. International Immunopharmacology 2023, 118: 110092. PMID: 37004344, DOI: 10.1016/j.intimp.2023.110092.Peer-Reviewed Original ResearchConceptsImmune checkpoint blockadeSoluble PD-L1 (sPD-L1) levelsPD-L1 ratioPD-L1 levelsSoluble PD-1Soluble PD-L1PD-L1PD-1Patient survivalSurvival statusPD-1/PD-L1Immune checkpoints PD-1T cell exhaustionPatients' survival statusSolid tumor typesInitial immunotherapyCheckpoint blockadeMelanoma patientsPoor prognosisRetrospective studyPatient responseCell exhaustionTumor typesMelanomaSurvival
2015
Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA)
Petrick JL, Steck SE, Bradshaw PT, Trivers KF, Abrahamson PE, Engel LS, He K, Chow WH, Mayne ST, Risch HA, Vaughan TL, Gammon MD. Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA). British Journal Of Cancer 2015, 112: 1291-1300. PMID: 25668011, PMCID: PMC4385952, DOI: 10.1038/bjc.2015.25.Peer-Reviewed Original ResearchConceptsOdds ratioHazard ratioFlavonoid intakeGastric cancerFood frequency questionnaire responsesMulticentre population-based studyIntake of anthocyanidinsLowest intake quartilesTotal flavonoid intakeFrequency-matched controlsPopulation-based studyProportional hazards regressionRisk of mortalityUSDA flavonoid databasesCase participantsAnthocyanidin intakeIntake quartilesHazards regressionVital statusDietary intakeChemopreventive effectsEpidemiologic studiesTumor typesFlavonoid databaseCancer
2007
Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas
Terry MB, Gammon MD, Zhang FF, Vaughan TL, Chow WH, Risch HA, Schoenberg JB, Mayne ST, Stanford JL, West AB, Rotterdam H, Blot WJ, Fraumeni JF, Santella RM. Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas. Cancer Causes & Control 2007, 18: 1039-1046. PMID: 17665311, DOI: 10.1007/s10552-007-9046-0.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAlcohol DehydrogenaseAlcohol DrinkingAllelesCase-Control StudiesChi-Square DistributionConfidence IntervalsEsophageal NeoplasmsFemaleGene FrequencyGenotypeHomozygoteHumansInterviews as TopicLogistic ModelsMaleMiddle AgedOdds RatioPolymorphism, GeneticRisk FactorsStomach NeoplasmsUnited StatesConceptsRisk of esophagealEsophageal adenocarcinomaHigh riskGastric Cancer StudyGastric cardia adenocarcinomaGastric adenocarcinomaCarcinoma riskConclusionThese dataCancer riskCardia adenocarcinomaTumor typesAdenocarcinomaAlcohol dehydrogenase 3Common polymorphismsEsophagealRisk estimatesCancer studiesRiskAlcohol dehydrogenase 3 geneDrinkersDehydrogenase 3PolymorphismNondrinkersMethodsWeGenotypes
2006
PGR +331 A/G and Increased Risk of Epithelial Ovarian Cancer
Risch HA, Bale AE, Beck PA, Zheng W. PGR +331 A/G and Increased Risk of Epithelial Ovarian Cancer. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 1738-1741. PMID: 16985038, DOI: 10.1158/1055-9965.epi-06-0272.Peer-Reviewed Original ResearchConceptsOvarian cancerA allelePostmenopausal womenProgesterone receptor gene polymorphismHistologic tumor typePopulation-based studyEpithelial ovarian cancerEffect of progesteroneReceptor gene polymorphismsPremenopausal womenEndometrial cancerMenopausal statusOral contraceptivesOvarian neoplasiaProgesterone receptorProgestin exposureG genotypeGG genotypeGene polymorphismsTumor typesReceptor isoformsCancerWomenRiskProgesterone
2001
Nutrient intake and risk of subtypes of esophageal and gastric cancer.
Mayne ST, Risch HA, Dubrow R, Chow WH, Gammon MD, Vaughan TL, Farrow DC, Schoenberg JB, Stanford JL, Ahsan H, West AB, Rotterdam H, Blot WJ, Fraumeni JF. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 1055-62. PMID: 11588131.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAge DistributionAgedCarcinoma, Squamous CellCase-Control StudiesConfidence IntervalsConnecticutDietEsophageal NeoplasmsFemaleHumansIncidenceMaleMiddle AgedNew JerseyOdds RatioPopulation SurveillanceReference ValuesRisk AssessmentRisk FactorsSex DistributionStomach NeoplasmsWashingtonConceptsNoncardia gastric cancerGastric cancerGastric cardiaNutrient intakeEsophageal adenocarcinomaOdds ratioHigh intakeTumor typesPopulation-based case-control studyVitamin C supplement useEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaRisk of adenocarcinomaSquamous cell carcinomaRisk of subtypesCase-control studyRisk of cancerPercentile of intakeSupplement useCell carcinomaDietary nitriteGastric adenocarcinomaRisk factorsDietary cholesterolIncidence rate
1997
Tobacco, Alcohol, and Socioeconomic Status and Adenocarcinomas of the Esophagus and Gastric Cardia
Gammon M, Ahsan H, Schoenberg J, West A, Rotterdam H, Niwa S, Blot W, Risch H, Dubrow R, Mayne S, Vaughan T, Stanford J, Farrow D, Chow W, Fraumeni J. Tobacco, Alcohol, and Socioeconomic Status and Adenocarcinomas of the Esophagus and Gastric Cardia. Journal Of The National Cancer Institute 1997, 89: 1277-1284. PMID: 9293918, DOI: 10.1093/jnci/89.17.1277.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaGastric cardiaSquamous cell carcinomaCell carcinomaGastric adenocarcinomaRisk factorsTumor typesNoncardia gastric adenocarcinomaDuration of smokingCurrent cigarette smokersRisk of esophagealMajor risk factorCase-control studyGastric cardia adenocarcinomaEarly-stage carcinogenesisCigarette smokersHigher ORsControl subjectsIncidence rateSimilar ORsCardia adenocarcinomaEstimates of riskAdenocarcinomaCardiaSmoking