2017
Epidemiologic factors that predict long-term survival following a diagnosis of epithelial ovarian cancer
Kim SJ, Rosen B, Fan I, Ivanova A, McLaughlin JR, Risch H, Narod SA, Kotsopoulos J. Epidemiologic factors that predict long-term survival following a diagnosis of epithelial ovarian cancer. British Journal Of Cancer 2017, 116: 964-971. PMID: 28208158, PMCID: PMC5379147, DOI: 10.1038/bjc.2017.35.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, Clear CellAdenocarcinoma, MucinousAdultAgedCanadaCystadenocarcinoma, SerousEndometrial NeoplasmsEpidemiologic FactorsFemaleFollow-Up StudiesHormone Replacement TherapyHumansMiddle AgedNeoplasm InvasivenessNeoplasm StagingOvarian NeoplasmsParityPregnancyPrognosisReproductive HistoryYoung AdultConceptsOvarian cancer-specific mortalityCancer-specific mortalityHormone replacement therapyRisk of deathEpithelial ovarian cancerOvarian cancerHazard ratioEpidemiologic factorsOvulatory cyclesOvarian cancer-specific deathOvarian cancer-specific survivalInvasive epithelial ovarian cancerBMI 5 yearsCancer-specific survivalCancer-specific deathOntario Cancer RegistryProportional hazards regressionConfidence intervalsBorderline significant associationOvarian cancer developmentLong-term survivalGreater cumulative numberHRT useCancer RegistryHistologic subtype
2014
Risk Factors for Ovarian Cancers With and Without Microsatellite Instability
Segev Y, Pal T, Rosen B, McLaughlin JR, Sellers TA, Risch HA, Zhang S, Sun P, Narod SA, Schildkraut J. Risk Factors for Ovarian Cancers With and Without Microsatellite Instability. International Journal Of Gynecological Cancer 2014, 24: 664-669. PMID: 24755492, DOI: 10.1097/igc.0000000000000134.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, Clear CellAdenocarcinoma, MucinousBRCA1 ProteinBRCA2 ProteinBreast NeoplasmsCanadaCystadenocarcinoma, SerousDNA, NeoplasmEndometrial NeoplasmsFemaleGenetic Predisposition to DiseaseHumansMicrosatellite InstabilityMicrosatellite RepeatsMiddle AgedMutationNeoplasm StagingOvarian NeoplasmsPrognosisRisk FactorsSyndromeUnited StatesConceptsOvarian cancer patientsOral contraceptive useBody mass indexEpithelial ovarian cancerOvarian cancerCancer patientsHistologic subtypeMass indexTubal ligationRisk factorsBRCA2 mutationsContraceptive usePast oral contraceptive usePrimary epithelial ovarian cancerOvarian cancer risk factorsBRCA1 mutationsNational Cancer Institute criteriaProtective factorsSpecific histologic subtypesCancer risk factorsPopulation-based studyMSI-high cancersCases of cancerMSI-high tumorsBRCA2 mutation status
2013
PPM1D Mutations in Circulating White Blood Cells and the Risk for Ovarian Cancer
Akbari MR, Lepage P, Rosen B, McLaughlin J, Risch H, Minden M, Narod SA. PPM1D Mutations in Circulating White Blood Cells and the Risk for Ovarian Cancer. Journal Of The National Cancer Institute 2013, 106: djt323. PMID: 24262437, DOI: 10.1093/jnci/djt323.Peer-Reviewed Original ResearchMeSH KeywordsAgedBRCA1 ProteinBRCA2 ProteinBreast NeoplasmsCanadaCase-Control StudiesFemaleGenetic Predisposition to DiseaseHeterozygoteHumansIncidenceLeukocytesMiddle AgedMutationOdds RatioOvarian NeoplasmsPhosphoprotein PhosphatasesProportional Hazards ModelsProtein Phosphatase 2CRisk AssessmentRisk FactorsConceptsCase patientsWhite blood cellsOvarian cancerControl subjectsOvarian cancer case patientsFemale first-degree relativesBlood cellsCancer case patientsFirst-degree relativesLifetime riskBreast cancerFamily historyMutation carriersPatientsCancerPast historyTruncating mutationsBreastRiskMutationsSubjectsCellsNoncarriersMortalityWomenRisk Factors for Ovarian Cancers With and Without Microsatellite Instability
Segev Y, Pal T, Rosen B, McLaughlin JR, Sellers TA, Risch HA, Zhang S, Ping S, Narod SA, Schildkraut J. Risk Factors for Ovarian Cancers With and Without Microsatellite Instability. International Journal Of Gynecological Cancer 2013, 23: 1010. PMID: 23748177, PMCID: PMC3740723, DOI: 10.1097/igc.0b013e31829a5527.Peer-Reviewed Original ResearchConceptsOvarian cancer patientsOral contraceptive useBody mass indexEpithelial ovarian cancerOvarian cancerCancer patientsHistologic subtypeMass indexHistologic findingsTubal ligationRisk factorsContraceptive usePast oral contraceptive usePrimary epithelial ovarian cancerOvarian cancer risk factorsBRCA1 mutationsNational Cancer Institute criteriaProtective factorsDifferent histologic findingsSpecific histologic subtypesCancer risk factorsPopulation-based studyMSI-high cancersMSI-high tumorsBRCA2 mutation statusRecent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
Kelemen LE, Bandera EV, Terry KL, Rossing MA, Brinton LA, Doherty JA, Ness RB, Kjær S, Chang-Claude J, Köbel M, Lurie G, Thompson PJ, Carney ME, Moysich K, Edwards R, Bunker C, Jensen A, Høgdall E, Cramer DW, Vitonis AF, Olson SH, King M, Chandran U, Lissowska J, Garcia-Closas M, Yang H, Webb PM, Schildkraut JM, Goodman MT, Risch HA, , on behalf of the Australian Ovarian Cancer Study Group and Australian Cancer Study (Ovarian Cancer), and on behalf of the Ovarian Cancer Association Consortium. Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium. BMC Cancer 2013, 13: 28. PMID: 23339562, PMCID: PMC3568733, DOI: 10.1186/1471-2407-13-28.Peer-Reviewed Original ResearchConceptsOvarian carcinomaOvarian Cancer Association ConsortiumHistologic typeAlcohol intakeBorderline tumorsOdds ratioClear cell ovarian carcinomaOz/dModerate alcohol drinkingTumor histologic typeSpecific histologic typesCase-control studyConfidence intervalsRecent alcohol intakeRecent alcohol consumptionAverage daily intakeModifiable causesMucinous histologySmoking statusAlcohol drinkingStatistical heterogeneityOC casesRisk associationAlcohol consumptionDeadly cancer
2011
Nonsteroidal Anti-inflammatory Drug Use Reduces Risk of Adenocarcinomas of the Esophagus and Esophagogastric Junction in a Pooled Analysis
Liao LM, Vaughan TL, Corley DA, Cook MB, Casson AG, Kamangar F, Abnet CC, Risch HA, Giffen C, Freedman ND, Chow W, Sadeghi S, Pandeya N, Whiteman DC, Murray LJ, Bernstein L, Gammon MD, Wu AH. Nonsteroidal Anti-inflammatory Drug Use Reduces Risk of Adenocarcinomas of the Esophagus and Esophagogastric Junction in a Pooled Analysis. Gastroenterology 2011, 142: 442-452.e5. PMID: 22108196, PMCID: PMC3488768, DOI: 10.1053/j.gastro.2011.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdolescentAdultAgedAged, 80 and overAnticarcinogenic AgentsAnti-Inflammatory Agents, Non-SteroidalAustraliaCanadaCase-Control StudiesCohort StudiesEsophageal NeoplasmsEsophagogastric JunctionFemaleHumansLogistic ModelsMaleMiddle AgedOdds RatioRisk AssessmentRisk FactorsStomach NeoplasmsTime FactorsUnited StatesYoung AdultConceptsNonsteroidal anti-inflammatory drugsEsophagogastric junctional adenocarcinomaRisk of EACNSAID useEsophageal adenocarcinomaPooled analysisOdds ratioEsophagogastric junctionNonaspirin nonsteroidal anti-inflammatory drugsStudy-specific odds ratiosRandom-effects meta-analysis modelEffects meta-analysis modelPrevention of adenocarcinomaUse of aspirinSignificant reduced riskPopulation-based studyConfidence intervalsAnti-inflammatory drugsDuration of useEsophageal Adenocarcinoma ConsortiumMeta-analysis modelLogistic regression modelsJunctional adenocarcinomaMedication typeEAC riskClinical impact of unclassified variants of the BRCA1 and BRCA2 genes
Akbari MR, Zhang S, Fan I, Royer R, Li S, Risch H, McLaughlin J, Rosen B, Sun P, Narod SA. Clinical impact of unclassified variants of the BRCA1 and BRCA2 genes. Journal Of Medical Genetics 2011, 48: 783. PMID: 21965345, DOI: 10.1136/jmedgenet-2011-100305.Peer-Reviewed Original ResearchConceptsFirst-degree relativesFemale first-degree relativesRelatives of patientsOvarian cancerCumulative riskPathogenic mutationsUnclassified variantsRisk of cancerHistorical cohortBRCA2 mutationsClinical impactHigh riskBRCA2 genesCancerUnknown significancePatientsMissense variantsFunctional effectsWomenRiskBRCA1PenetranceMutationsRelativesCohort
2003
The N314D polymorphism of galactose-1-phosphate uridyl transferase does not modify the risk of ovarian cancer.
Fung WL, Risch H, McLaughlin J, Rosen B, Cole D, Vesprini D, Narod SA. The N314D polymorphism of galactose-1-phosphate uridyl transferase does not modify the risk of ovarian cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 678-80. PMID: 12869412.Peer-Reviewed Original Research
1993
Canadian National Breast Screening Study: first screen results as predictors of future breast cancer risk.
Holowaty P, Miller A, Baines C, Risch H. Canadian National Breast Screening Study: first screen results as predictors of future breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 1993, 2: 11-9. PMID: 8420606.Peer-Reviewed Original ResearchConceptsRisk factorsBreast cancerYears menstruatingPhysical examinationCanadian National Breast Screening StudyNational Breast Screening StudyFuture breast cancer riskSelf-reported risk factorsBreast Screening StudyInvasive breast cancerRisk factor informationSignificant risk factorsBreast cancer riskEtiological risk factorsCharacteristics of womenSelf-administered questionnaireTwo-view mammographic examinationBreast screenStudy populationParenchymal patternsCancer riskMammographic examinationsScreen resultsStudy designFactor information
1988
DIETARY FACTORS AND THE INCIDENCE OF CANCER OF THE URINARY BLADDER
RISCH H, BURCH J, MILLER A, HILL G, STEELE R, HOWE G. DIETARY FACTORS AND THE INCIDENCE OF CANCER OF THE URINARY BLADDER. American Journal Of Epidemiology 1988, 127: 1179-1191. PMID: 3369417, DOI: 10.1093/oxfordjournals.aje.a114911.Peer-Reviewed Original ResearchConceptsBladder cancerDietary factorsLow-calorie foodsConditional logistic regression methodsCalorie foodsIntake of cholesterolCase-control studyAge 20 yearsLife-style factorsIncidence of cancerHistory of exposureLack of associationOdds ratio estimatesArtificial sweetenersArea of residenceAverage daily intakeDiabetes mellitusCigarette smokingSubsequent riskCancer casesUrinary bladderRelevant food itemsMild increaseCancerDaily intakeLymphocyte micronuclei and sister chromatid exchanges among Canadian federal laboratory employees
Narod S, Neri L, Risch H, Raman S. Lymphocyte micronuclei and sister chromatid exchanges among Canadian federal laboratory employees. American Journal Of Industrial Medicine 1988, 14: 449-456. PMID: 3055975, DOI: 10.1002/ajim.4700140408.Peer-Reviewed Original Research
1986
Changes in breast self‐examination behavior in a cohort of 8214 women in the Canadian national breast screening study
Baines C, Bsc C, Risch H, Kuin J, Fan I. Changes in breast self‐examination behavior in a cohort of 8214 women in the Canadian national breast screening study. Cancer 1986, 57: 1209-1216. PMID: 3510711, DOI: 10.1002/1097-0142(19860315)57:6<1209::aid-cncr2820570625>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsCanadian National Breast Screening StudyNational Breast Screening StudyBreast Screening StudyBSE frequencyBreast self-examination instructionSelf-reported BSE frequencyBSE behaviorMean numberScreening studyBreast self-examination behaviorRoutine medical examSelf-examination behaviorStudy cohortThird screenBreast examScreen 3Older womenMedical examsWomenScreen 2CohortEvaluation protocolExamCriteriaBreast
1985
DIETARY FACTORS AND THE INCIDENCE OF CANCER OF THE STOMACH
RISCH H, JAIN M, CHOI N, FODOR J, PFEIFFER C, HOWE G, HARRISON L, CRAIB K, MILLER A. DIETARY FACTORS AND THE INCIDENCE OF CANCER OF THE STOMACH. American Journal Of Epidemiology 1985, 122: 947-959. PMID: 2998182, DOI: 10.1093/oxfordjournals.aje.a114199.Peer-Reviewed Original ResearchConceptsOdds ratio estimatesStomach cancerConditional logistic regression methodsVitamin C intakeCitrus fruit intakeCase-control studyIncidence of cancerArea of residenceAverage daily intakeC intakeFruit intakeRatio estimatesDietary factorsAverage daily consumptionCancer casesGastric cancerVitamin EDaily intakeCancerDietary componentsDaily consumptionLogistic regression methodIntakePopulation controlsDietary fiber