SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion
Chen X, Wang H, Bajaj K, Zhang P, Meng Z, Ma D, Bai Y, Liu H, Adams E, Baines A, Yu G, Sartor M, Zhang B, Yi Z, Lin J, Young S, Schekman R, Ginsburg D. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. ELife 2013, 2: e00444. PMID: 23580231, PMCID: PMC3622177, DOI: 10.7554/elife.00444.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins ECell Line, TumorCholesterolCOP-Coated VesiclesDown-RegulationDyslipidemiasEndoplasmic ReticulumEpistasis, GeneticGenotypeHEK293 CellsHumansLiverMice, 129 StrainMice, Inbred C57BLMice, KnockoutMutationPhenotypeProprotein Convertase 9Proprotein ConvertasesProtein TransportReceptors, LDLSerine EndopeptidasesTransfectionVesicular Transport ProteinsConceptsEndoplasmic reticulumCOPII vesicle formationCargo recruitmentCOPII vesiclesCargo proteinsEukaryotic cellsCargo selectivitySecretory pathwaySEC24AEfficient exitUnappreciated heterogeneityNegative regulatorSecretory proteinsVesicle formationPCSK9 secretionComplete genetic deficiencyGenetic deficiencyLDLR levelsProteinVesiclesFundamental roleNormal survivalPartial overlapRecruitmentSEC24B