2018
Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema
Cornwell WD, Kim C, Lastra AC, Dass C, Bolla S, Wang H, Zhao H, Ramsey FV, Marchetti N, Rogers TJ, Criner GJ. Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema. Biomarkers 2018, 24: 232-239. PMID: 30411980, PMCID: PMC6509019, DOI: 10.1080/1354750x.2018.1542458.Peer-Reviewed Original ResearchConceptsInterstitial pulmonary fibrosisInflammatory profilePulmonary fibrosisLung tissueInflammatory proteinDistinct inflammatory profilesCohort of patientsCombined pulmonary fibrosisDistinct inflammatory processesEmphysematous lung tissueInflammatory protein levelsExplanted LungsInflammatory signatureInflammatory processDisease processEmphysemaPatientsEmphysematous tissueFibrosisLungProtein levelsTissue sectionsCPFETissueTissue extracts
2000
Rat sponge implant model: a new system for evaluating angiogenic gene transfer.
Wang H, Gordon D, Olszewski B, Song Y, Kovesdi I, Keiser J. Rat sponge implant model: a new system for evaluating angiogenic gene transfer. International Journal Of Molecular Medicine 2000, 6: 645-53. PMID: 11078823, DOI: 10.3892/ijmm.6.6.645.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsBeta-GalactosidaseBlood VesselsDNA, RecombinantDose-Response Relationship, DrugEndothelial Growth FactorsGene Transfer TechniquesGene Transfer, HorizontalHumansImmunohistochemistryLymphokinesModels, CardiovascularNeovascularization, PathologicProstheses and ImplantsRatsRecombinant Fusion ProteinsSurgical SpongesTime FactorsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsVon Willebrand FactorConceptsBeta-galactosidase reporter geneSuch genesReporter geneGenesGene transferTransfection efficiencyAngiogenic genesGene therapyProtein levelsProtein expressionVEGF121 geneReplication-deficient adenovirus vectorModel systemSponge implant modelAngiogenic responseProtein injectionAngiogenesisAdenovirus vectorVEGF protein expressionAngiogenic effectsProtein concentrationEnhanced angiogenesisAngiogenic efficacyGene transfection efficiencyHigh levels
1997
Expression of syndecan-1 in rabbit neointima following de-endothelialization by a balloon catheter
Wang H, Moore S, Alavi M. Expression of syndecan-1 in rabbit neointima following de-endothelialization by a balloon catheter. Atherosclerosis 1997, 131: 141-147. PMID: 9199266, DOI: 10.1016/s0021-9150(97)06078-4.Peer-Reviewed Original ResearchConceptsSyndecan-1Low density lipoprotein retentionSyndecan-1 expressionArterial injuryBalloon catheterImmunohistochemical stainingEarly atherogenesisNeointimal cellsPositive cellsArterial neointimaRabbit aortaNormal aortaNeointimal tissueRabbit neointimaAortic neointimaNeointimaLipoprotein retentionCell membrane proteoglycansGrowth factorProtein levelsExtracellular matrix componentsNorthern blot analysisAortaBlot analysisInjury
1996
Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in rabbit aortic neointima after selective de-endothelialization
Wang H, Moore S, Alavi M. Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in rabbit aortic neointima after selective de-endothelialization. Atherosclerosis 1996, 126: 95-104. PMID: 8879438, DOI: 10.1016/0021-9150(96)05898-4.Peer-Reviewed Original ResearchConceptsTIMP-1 geneRabbit formsApparent homologyExtracellular matrix metabolismExpression systemTIMP-1 expressionSoluble proteinNorthern blotSitu hybridization techniqueEscherichia coliProtein levelsMatrix metabolismGenesAortic neointimaNeointimal SMCsHybridization techniqueNucleic acidsWestern blotTIMP-1Tissue inhibitorExpressionBlotMetalloproteinase-1CDNAInhibitors