2020
E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1
Pham K, Huynh D, Le L, Delitto D, Yang L, Huang J, Kang Y, Steinberg MB, Li J, Zhang L, Liu D, Tang MS, Liu C, Wang H. E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1. Cancer Letters 2020, 491: 132-145. PMID: 32829009, PMCID: PMC9703643, DOI: 10.1016/j.canlet.2020.08.010.Peer-Reviewed Original ResearchConceptsBC cell growthCig exposureLung metastasesBreast cancerVCAM-1V-CAM-1Role of CCL5Upregulated protein expressionBC cell survivalE-cig exposurePro-tumorigenic factorsBC cell apoptosisBreast carcinoma progressionMetastatic lung colonizationCCR5 axisMFP tumorsTAMs infiltrationInfiltrated macrophagesCell growthCo-culture systemImmunohistochemical stainsCell crosstalkBC cellsBC growthProliferation index
2012
SEC23B is required for the maintenance of murine professional secretory tissues
Tao J, Zhu M, Wang H, Afelik S, Vasievich M, Chen X, Zhu G, Jensen J, Ginsburg D, Zhang B. SEC23B is required for the maintenance of murine professional secretory tissues. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: e2001-e2009. PMID: 22745161, PMCID: PMC3406820, DOI: 10.1073/pnas.1209207109.Peer-Reviewed Original ResearchMeSH KeywordsAlcian BlueAnimalsAnthraquinonesApoptosisEndoplasmic ReticulumFluorescent Antibody TechniqueHumansIn Situ Nick-End LabelingMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ImmunoelectronMutationPancreasReal-Time Polymerase Chain ReactionSecretory PathwaySpecies SpecificityVesicular Transport ProteinsConceptsEndoplasmic reticulumSecretory tissueSpecies-specific shiftsGTPase-activating proteinsUnfolded protein responseAccumulation of proteinsSimilar ultrastructural alterationsAbundant cargoCargo recognitionEukaryotic cellsSar1 GTPaseER exitER lumenSecretory pathwayTissue-specific dependenceProtein responseHypomorphic mutationsSecretory proteinsSEC23BDisparate phenotypesCOPIICongenital dyserythropoietic anemia type IIEmbryonic pancreasAnemia phenotypeProapoptotic pathways
1998
Molecular characterization of rabbit CPP32 and its function in vascular smooth muscle cell apoptosis
Wang H, Keiser J. Molecular characterization of rabbit CPP32 and its function in vascular smooth muscle cell apoptosis. American Journal Of Physiology 1998, 274: h1132-h1140. PMID: 9575916, DOI: 10.1152/ajpheart.1998.274.4.h1132.Peer-Reviewed Original ResearchConceptsCPP32 mRNASmooth muscle cellsDEVD-CHOSNP treatmentSignal transduction eventsCell death detection enzyme-linked immunosorbentDegradation of PARPApoptotic cell deathRabbit smooth muscle cellsVascular smooth muscle cell apoptosisCultured arterial smooth muscle cellsCaspase membersSmooth muscle cell apoptosisDNA fragmentation analysisMuscle cell apoptosisSubstrate recognitionTransduction eventsCPP32 proteinArterial smooth muscle cellsCultured smooth muscle cellsVascular smooth muscle cellsProtease familyDegenerate primersApoptosis pathwayCentral player