2004
Dose‐Dependent Neovascularization‐Promoting Effect of Adenovirus Vector CI‐1023 in a Rat Hindlimb Ischaemic Model
Wang H, Keiser J, Olszewski B, Brammer D, Gordon D. Dose‐Dependent Neovascularization‐Promoting Effect of Adenovirus Vector CI‐1023 in a Rat Hindlimb Ischaemic Model. Basic & Clinical Pharmacology & Toxicology 2004, 95: 76-80. PMID: 15379784, DOI: 10.1111/j.1742-7843.2004.950206.x.Peer-Reviewed Original ResearchConceptsHindlimb ischemic modelDose-dependent effectIschemic modelObvious dose-dependent effectDose rangeLocal tissue expressionVascular endothelial growth factor (VEGF) proteinReplication-deficient adenovirus vectorLaser Doppler scanningEfficacy of CIWide dose rangeGrowth factor proteinDoppler scanningImmuno-histochemistryTissue blood perfusionBlood perfusionTissue expressionAdenovirus vectorFactor proteinPrevious studiesAngiographyDelayed angiogenesis in aging rats and therapeutic effect of adenoviral gene transfer of VEGF.
Wang H, Keiser J, Olszewski B, Rosebury W, Robertson A, Kovesdi I, Gordon D. Delayed angiogenesis in aging rats and therapeutic effect of adenoviral gene transfer of VEGF. International Journal Of Molecular Medicine 2004, 13: 581-7. PMID: 15010860, DOI: 10.3892/ijmm.13.4.581.Peer-Reviewed Original ResearchAdenoviridaeAgingAnimalsBlotting, NorthernCell DivisionEndothelium, VascularEnzyme-Linked Immunosorbent AssayGene Transfer TechniquesHumansImmunoblottingImmunohistochemistryNeovascularization, PathologicNeovascularization, PhysiologicRatsTime FactorsTransfectionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2
1998
Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells
Wang H, Keiser J. Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells. Circulation Research 1998, 83: 832-840. PMID: 9776730, DOI: 10.1161/01.res.83.8.832.Peer-Reviewed Original ResearchMeSH KeywordsAortaBiocompatible MaterialsCell DivisionCell MovementCells, CulturedCollagenCollagenasesDrug CombinationsEndothelial Growth FactorsEndothelium, VascularEnzyme ActivationEnzyme-Linked Immunosorbent AssayExtracellular MatrixGelsGene Expression Regulation, EnzymologicHumansLamininLymphokinesMatrix Metalloproteinase 1Matrix Metalloproteinase 9Muscle, Smooth, VascularNeovascularization, PhysiologicPhosphorylationProteoglycansProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesRNA, MessengerVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsHuman smooth muscle cellsKinase insert domain-containing receptorSmooth muscle cellsVascular smooth muscle cellsSMC migrationSignal transduction pathwaysVascular endothelial growth factorExtracellular matrix barriersMuscle cellsNorthern blot analysisMajor cell typesEffects of VEGFGrowth factorDomain-containing receptorTransduction pathwaysInsert domain-containing receptorFlt-1Endothelial cells