2021
Tumor suppressor p53 regulates intestinal type 2 immunity
Chang C, Wang J, Zhao Y, Liu J, Yang X, Yue X, Wang H, Zhou F, Inclan-Rico J, Ponessa J, Xie P, Zhang L, Siracusa M, Feng Z, Hu W. Tumor suppressor p53 regulates intestinal type 2 immunity. Nature Communications 2021, 12: 3371. PMID: 34099671, PMCID: PMC8184793, DOI: 10.1038/s41467-021-23587-x.Peer-Reviewed Original ResearchConceptsType 2 immunityRole of p53Parasitic infectionsInnate lymphoid cell responsesLymphoid cell responsesImmune integrityInfection of parasitesNippostrongylus brasiliensisTuft cellsCell responsesImmunityInfectionTritrichomonas murisTumor suppressor p53P53Unrecognized functionTumor suppressionSuppressor p53Critical triggerCritical roleCell circuitRoleResponse
2020
Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis
Li J, Huynh L, Cornwell WD, Tang MS, Simborio H, Huang J, Kosmider B, Rogers TJ, Zhao H, Steinberg MB, Thu Thi Le L, Zhang L, Pham K, Liu C, Wang H. Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2020, 41: 839-853. PMID: 33380174, PMCID: PMC8608030, DOI: 10.1161/atvbaha.120.315556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAtherosclerosisDisease Models, AnimalDNA DamageDNA, MitochondrialE-Cigarette VaporFemaleHumansInflammationInflammation MediatorsMacrophagesMaleMiceMice, Inbred C57BLMice, Knockout, ApoEMiddle AgedMitochondriaRAW 264.7 CellsSignal TransductionSmokersToll-Like Receptor 9VapingConceptsECV exposureTLR9 expressionInflammatory cytokinesClassical monocytesTLR9 activationAtherosclerotic plaquesEight-week-old ApoEUpregulation of TLR9Expression of TLR9Atherosclerotic lesion developmentOil Red O stainingToll-like receptorsDays/weekE-cig exposureMonocytes/macrophagesNormal laboratory dietRed O stainingPotential pharmacological targetElectronic cigarette useHours/dayProinflammatory cytokinesCig vaporPlasma levelsTLR9 antagonistTLR9 inhibitorThe Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy
Liu D, Badeti S, Dotti G, Jiang JG, Wang H, Dermody J, Soteropoulos P, Streck D, Birge RB, Liu C. The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy. Cell Communication And Signaling 2020, 18: 134. PMID: 32843053, PMCID: PMC7446110, DOI: 10.1186/s12964-020-00617-7.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor (CAR) immunotherapyCAR immunotherapyCancer immunotherapyClinical outcomesImmune cellsImmunological synapseCancer therapyPrecision cancer immunotherapyRefractory blood cancersRecent clinical trialsTumor antigen specificityUnique cell surface receptorChimeric antigen receptorImmune cell activationAdoptive transferImmunotherapeutic strategiesSuppressor cellsClinical predictorsCell immunotherapyClinical trialsIndividual patientsImmunotherapyAntigen specificityCell activationBlood cancersE-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1
Pham K, Huynh D, Le L, Delitto D, Yang L, Huang J, Kang Y, Steinberg MB, Li J, Zhang L, Liu D, Tang MS, Liu C, Wang H. E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1. Cancer Letters 2020, 491: 132-145. PMID: 32829009, PMCID: PMC9703643, DOI: 10.1016/j.canlet.2020.08.010.Peer-Reviewed Original ResearchConceptsBC cell growthCig exposureLung metastasesBreast cancerVCAM-1V-CAM-1Role of CCL5Upregulated protein expressionBC cell survivalE-cig exposurePro-tumorigenic factorsBC cell apoptosisBreast carcinoma progressionMetastatic lung colonizationCCR5 axisMFP tumorsTAMs infiltrationInfiltrated macrophagesCell growthCo-culture systemImmunohistochemical stainsCell crosstalkBC cellsBC growthProliferation indexIatrogenic Cholesteatoma Presenting as Neck Mass
Vella JB, Wackym PA, Wang H, Roychowdhury ST. Iatrogenic Cholesteatoma Presenting as Neck Mass. The Laryngoscope 2020, 131: e882-e884. PMID: 32770806, DOI: 10.1002/lary.28941.Peer-Reviewed Original ResearchPulmonary vasculopathy in explanted lungs from patients with interstitial lung disease undergoing lung transplantation
Dotan Y, Stewart J, Gangemi A, Wang H, Aneja A, Chakraborty B, Dass C, Zhao H, Marchetti N, D'Alonzo G, Cordova FC, Criner G, Mamary AJ. Pulmonary vasculopathy in explanted lungs from patients with interstitial lung disease undergoing lung transplantation. BMJ Open Respiratory Research 2020, 7: e000532. PMID: 32661103, PMCID: PMC7359183, DOI: 10.1136/bmjresp-2019-000532.Peer-Reviewed Original ResearchConceptsFibrotic interstitial lung diseaseMean pulmonary artery pressureRight heart catheterisationInterstitial lung diseaseAdvanced fibrotic interstitial lung diseasesPulmonary arterial vasculopathySevere pulmonary hypertensionPulmonary hypertensionArterial vasculopathyLung transplantationLung diseaseEnd-stage interstitial lung diseaseSeverity of PHModerate pulmonary hypertensionPulmonary artery pressureIdiopathic pulmonary hypertensionIdiopathic pulmonary fibrosisHuman lung tissueArtery pressureHeart catheterisationPlexiform lesionsAdult patientsIntimal fibrosisPulmonary fibrosisLung diffusionCytologic grading of primary malignant salivary gland tumors: A blinded review by an international panel
Johnson DN, Onenerk M, Krane JF, Rossi ED, Baloch Z, Barkan G, Bongiovanni M, Callegari F, Canberk S, Dixon G, Field A, Griffith CC, Jhala N, Jiang S, Kurtycz D, Layfield L, Lin O, Maleki Z, Perez‐Machado M, Pusztaszeri M, Vielh P, Wang H, Zarka MA, Faquin WC. Cytologic grading of primary malignant salivary gland tumors: A blinded review by an international panel. Cancer Cytopathology 2020, 128: 392-402. PMID: 32267606, PMCID: PMC7413070, DOI: 10.1002/cncy.22271.Peer-Reviewed Original ResearchConceptsSalivary gland carcinomasFine-needle aspirationPrimary salivary gland carcinomaSalivary gland tumorsTumor gradeMedical CenterSGC casesGland tumorsPrimary malignant salivary gland tumorsHigh-grade salivary gland carcinomasMalignant salivary gland tumorsTertiary medical centerSalivary duct carcinomaCorresponding resection specimensAcinic cell carcinomaEpithelial-myoepithelial carcinomaAcademic medical centerSalivary gland fine-needle aspirationPreoperative evaluationStudy cohortDuct carcinomaCell carcinomaHistologic diagnosisHistopathologic examinationInternational panelThe role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
Brown M, Zhang W, Yan D, Kenath R, Le L, Wang H, Delitto D, Ostrov D, Robertson K, Liu C, Pham K. The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC. PLOS ONE 2020, 15: e0226917. PMID: 31929540, PMCID: PMC6957139, DOI: 10.1371/journal.pone.0226917.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaTypes of cancerDuctal adenocarcinomaSurvivin expressionSurvivin inhibitorClinical response rateNovel survivin inhibitorHalf of patientsElevated survivin expressionLower patient survivalPancreatic tumor microenvironmentPotential therapeutic targetExpression of survivinRole of survivinField of oncologyPancreatic cancer linesImmunotherapeutic approachesPatient survivalUntreated cohortTherapeutic responseInhibitor of survivinTreatment resistancePDAC progressionEffective treatmentTumor cell migration
2019
Problems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study
Shih AR, Uruga H, Bozkurtlar E, Chung J, Hariri LP, Minami Y, Wang H, Yoshizawa A, Muzikansky A, Moreira AL, Mino‐Kenudson M. Problems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study. Histopathology 2019, 75: 649-659. PMID: 31107973, DOI: 10.1111/his.13922.Peer-Reviewed Original ResearchConceptsSmall lung adenocarcinomaInvasive adenocarcinomaLung adenocarcinomaLung pathologistsElastic stainInterobserver agreementHigh-grade cytologyLow-grade cytologyInvasive component sizeReproducibility of classificationHistological patternFinal diagnosisInvasive componentAdenocarcinomaConsensus conferenceRoutine assessmentInterobserver studyInconsistent classificationPredominant patternSingle caseKappa valuesCytologyPathologistsPrimary salivary gland‐type tumors of the tracheobronchial tree diagnosed by transbronchial fine needle aspiration: Clinical and cytomorphologic features with histopathologic correlation
Doxtader EE, Shah AA, Zhang Y, Wang H, Dyhdalo KS, Farver C. Primary salivary gland‐type tumors of the tracheobronchial tree diagnosed by transbronchial fine needle aspiration: Clinical and cytomorphologic features with histopathologic correlation. Diagnostic Cytopathology 2019, 47: 1168-1176. PMID: 31343850, DOI: 10.1002/dc.24285.Peer-Reviewed Original ResearchConceptsSalivary gland-type tumorsTransbronchial fine needle aspirationPrimary salivary gland-type tumorsFine-needle aspirationTracheobronchial treeSalivary gland tumorsNeedle aspirationCytomorphologic featuresGland tumorsSalivary gland-type neoplasmsPrimary salivary gland tumorsSurgical pathology specimenClear cell carcinomaCorresponding surgical specimenAdenoid cystic carcinomaEpithelial-myoepithelial carcinomaSurgical pathology specimensSalivary gland typeEndobronchial biopsyFrequent diagnosisStudy cohortLung massTracheal massCell carcinomaCytomorphologic changesThe Evolving Field of Cytopathology and Its Expanding Role in Pathologic Practice
Wang H, Jhala N. The Evolving Field of Cytopathology and Its Expanding Role in Pathologic Practice. Archives Of Pathology & Laboratory Medicine 2019, 143: 662-663. PMID: 31121108, DOI: 10.5858/arpa.2018-0530-ed.Peer-Reviewed Original ResearchApplication of the Milan System for Reporting Submandibular Gland Cytopathology: An international, multi‐institutional study
Maleki Z, Baloch Z, Lu R, Shafique K, Song SJ, Viswanathan K, Rao RA, Lefler H, Fatima A, Wiles A, Jo VY, Wang H, Fadda G, Powers CN, Ali SZ, Pantanowitz L, Siddiqui MT, Nayar R, Klijanienko J, Barkan GA, Krane JF, Rossi ED, Callegari F, Kholová I, Bongiovanni M, Faquin WC, Pusztaszeri MP. Application of the Milan System for Reporting Submandibular Gland Cytopathology: An international, multi‐institutional study. Cancer Cytopathology 2019, 127: 306-315. PMID: 31050186, PMCID: PMC7404554, DOI: 10.1002/cncy.22135.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overAlgorithmsBiopsy, Fine-NeedleChildChild, PreschoolCytodiagnosisFemaleFollow-Up StudiesHealth FacilitiesHumansInfantInternational AgenciesMaleMedical RecordsMiddle AgedPrecancerous ConditionsRetrospective StudiesRisk AssessmentSalivary Gland NeoplasmsSubmandibular GlandYoung AdultThe Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outcomes: An Institutional Experience, Systematic Review, and Meta-analysis
Luo X, Khurana JS, Jhala N, Zhao H, Wang H. The Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outcomes: An Institutional Experience, Systematic Review, and Meta-analysis. Archives Of Pathology & Laboratory Medicine 2019, 143: 1012-1021. PMID: 30702333, DOI: 10.5858/arpa.2017-0582-ra.Peer-Reviewed Original ResearchConceptsProstatic acinar adenocarcinomaAdverse outcomesCribriform lesionsAcinar adenocarcinomaInstitutional experienceObservational retrospective case-control studySystematic reviewProstate-specific antigen (PSA) recurrenceRetrospective case-control studyRegional lymph node metastasisBiochemical prostate-specific antigen recurrenceDisease-specific deathProspective cohort studyLymph node metastasisCase-control studySeminal vesicle invasionCohort studyLocal recurrenceNode metastasisPoor outcomeExtraprostatic extensionStudy qualityMeta-AnalysisLesionsOutcomes
2018
Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema
Cornwell WD, Kim C, Lastra AC, Dass C, Bolla S, Wang H, Zhao H, Ramsey FV, Marchetti N, Rogers TJ, Criner GJ. Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema. Biomarkers 2018, 24: 232-239. PMID: 30411980, PMCID: PMC6509019, DOI: 10.1080/1354750x.2018.1542458.Peer-Reviewed Original ResearchConceptsInterstitial pulmonary fibrosisInflammatory profilePulmonary fibrosisLung tissueInflammatory proteinDistinct inflammatory profilesCohort of patientsCombined pulmonary fibrosisDistinct inflammatory processesEmphysematous lung tissueInflammatory protein levelsExplanted LungsInflammatory signatureInflammatory processDisease processEmphysemaPatientsEmphysematous tissueFibrosisLungProtein levelsTissue sectionsCPFETissueTissue extractsMoving Toward a Systematic Approach for Reporting Salivary Gland Cytopathology: An Institutional Experience and Literature Review
Luo X, Jhala N, Khurana JS, Fundakowski C, Jhala DN, Wang H. Moving Toward a Systematic Approach for Reporting Salivary Gland Cytopathology: An Institutional Experience and Literature Review. Archives Of Pathology & Laboratory Medicine 2018, 143: 664-669. PMID: 30044125, DOI: 10.5858/arpa.2017-0283-ra.Peer-Reviewed Original ResearchGalNAc-Specific Soybean Lectin Inhibits HIV Infection of Macrophages through Induction of Antiviral Factors
Zhou R, Wang X, Liu H, Guo L, Su Q, Wang H, Vasiliadis T, Ho W, Li J. GalNAc-Specific Soybean Lectin Inhibits HIV Infection of Macrophages through Induction of Antiviral Factors. Journal Of Virology 2018, 92: 10.1128/jvi.01720-17. PMID: 29263266, PMCID: PMC5827391, DOI: 10.1128/jvi.01720-17.Peer-Reviewed Original ResearchConceptsMannose-binding lectinHIV infectionT cellsInterferon-stimulated genesMitogenic effectAntiviral factorsHIV agentsAttachment of HIVAntiviral interferon-stimulated genesActivation of CD4Suppression of HIVDose-dependent fashionGlycosylated envelope proteinsAnti-HIV activityGroups of macrophagesC chemokinesCoreceptor CCR5HIV gp120HIV microbicidesBeta interferonHIVClinical settingCD4InfectionMacrophages
2017
“Suspicious” salivary gland FNA: Risk of malignancy and interinstitutional variability
Maleki Z, Miller JA, Arab SE, Fadda G, Bo P, Wise O, Rossi ED, Jhala N, Ashish C, Ali SZ, Wang H. “Suspicious” salivary gland FNA: Risk of malignancy and interinstitutional variability. Cancer Cytopathology 2017, 126: 94-100. PMID: 29053216, DOI: 10.1002/cncy.21939.Peer-Reviewed Original ResearchConceptsRisk of malignancySalivary gland FNAsFNA specimensExact testSuspicious casesFine needle aspiration cytologyEpithelial metaplastic changesSignificant interinstitutional variabilityTertiary medical centerFisher's exact testSalivary gland neoplasmsSalivary gland lesionsSFM categoryMetaplastic changesMalignancy categoryConclusive diagnosisMalignant tumorsAspiration cytologyMedical CenterFNA casesIndeterminate resultsSFM groupGland neoplasmsSpecific neoplasmsGland lesions“Atypical” salivary gland fine needle aspiration: Risk of malignancy and interinstitutional variability
Wang H, Malik A, Maleki Z, Rossi ED, Ping B, Chandra A, Ali SZ, Fadda G, Wang J, Arab SE, Zhao H, Jhala N. “Atypical” salivary gland fine needle aspiration: Risk of malignancy and interinstitutional variability. Diagnostic Cytopathology 2017, 45: 1088-1094. PMID: 28960946, DOI: 10.1002/dc.23826.Peer-Reviewed Original ResearchConceptsRisk of malignancyFine-needle aspirationSalivary gland fine-needle aspirationMalignant tumorsNeedle aspirationTertiary medical centerSalivary gland lesionsHistological resectionSalivary Gland CytopathologyBenign tumorsMedical CenterAtypical diagnosisBenign neoplasmsBenign lesionsFNA yieldGland lesionsInterinstitutional variabilityDiagnostic categoriesMorphologic heterogeneityDiagnosisTumorsMilan SystemVariable practiceMalignancyLesionsClinically isolated aortitis: pitfalls, progress, and possibilities
Cinar I, Wang H, Stone J. Clinically isolated aortitis: pitfalls, progress, and possibilities. Cardiovascular Pathology 2017, 29: 23-32. PMID: 28500877, DOI: 10.1016/j.carpath.2017.04.003.Peer-Reviewed Original ResearchConceptsGiant cell arteritisExtracranial giant cell arteritisNon-infectious aortitisSubsequent aortic eventsSystemic rheumatologic diseaseComputed tomography scanningMagnetic resonance imagingPositron emission tomographyGiant cell patternAortic eventsImmunosuppressive therapyInfectious aortitisSystemic vasculitisCell arteritisRheumatologic diseasesClinical evidenceSystemic disordersAortic imagingAortitisAortic tissuePatientsResonance imagingTomography scanningEmission tomographyMultiple studies
2016
FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases
Wang H, Hoda R, Faquin W, Rossi E, Hotchandani N, Sun T, Pusztaszeri M, Bizzarro T, Bongiovanni M, Patel V, Jhala N, Fadda G, Gong Y. FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases. Cancer Cytopathology 2016, 125: 91-103. PMID: 28001329, DOI: 10.1002/cncy.21798.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsySquamous cell carcinomaDefinitive diagnosisDiagnostic challengeMetastatic squamous cell carcinomaDefinitive malignant diagnosisMean patient ageSalivary glandsCommon malignant neoplasmFalse-negative diagnosesPatient ageSecondary malignanciesMetastatic carcinomaCell carcinomaPathology databaseMalignant neoplasmsFNAB diagnosisFNAB casesMalignant diagnosisMetastatic chordomaAncillary studiesNasopharyngeal carcinomaAspiration biopsyAncillary testsOlder men