2020
E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1
Pham K, Huynh D, Le L, Delitto D, Yang L, Huang J, Kang Y, Steinberg MB, Li J, Zhang L, Liu D, Tang MS, Liu C, Wang H. E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1. Cancer Letters 2020, 491: 132-145. PMID: 32829009, PMCID: PMC9703643, DOI: 10.1016/j.canlet.2020.08.010.Peer-Reviewed Original ResearchConceptsBC cell growthCig exposureLung metastasesBreast cancerVCAM-1V-CAM-1Role of CCL5Upregulated protein expressionBC cell survivalE-cig exposurePro-tumorigenic factorsBC cell apoptosisBreast carcinoma progressionMetastatic lung colonizationCCR5 axisMFP tumorsTAMs infiltrationInfiltrated macrophagesCell growthCo-culture systemImmunohistochemical stainsCell crosstalkBC cellsBC growthProliferation index
2019
Problems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study
Shih AR, Uruga H, Bozkurtlar E, Chung J, Hariri LP, Minami Y, Wang H, Yoshizawa A, Muzikansky A, Moreira AL, Mino‐Kenudson M. Problems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study. Histopathology 2019, 75: 649-659. PMID: 31107973, DOI: 10.1111/his.13922.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma in SituAdenocarcinoma of LungCytodiagnosisHistocytochemistryHumansLung NeoplasmsPrognosisConceptsSmall lung adenocarcinomaInvasive adenocarcinomaLung adenocarcinomaLung pathologistsElastic stainInterobserver agreementHigh-grade cytologyLow-grade cytologyInvasive component sizeReproducibility of classificationHistological patternFinal diagnosisInvasive componentAdenocarcinomaConsensus conferenceRoutine assessmentInterobserver studyInconsistent classificationPredominant patternSingle caseKappa valuesCytologyPathologists
2016
FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases
Wang H, Hoda R, Faquin W, Rossi E, Hotchandani N, Sun T, Pusztaszeri M, Bizzarro T, Bongiovanni M, Patel V, Jhala N, Fadda G, Gong Y. FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases. Cancer Cytopathology 2016, 125: 91-103. PMID: 28001329, DOI: 10.1002/cncy.21798.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsySquamous cell carcinomaDefinitive diagnosisDiagnostic challengeMetastatic squamous cell carcinomaDefinitive malignant diagnosisMean patient ageSalivary glandsCommon malignant neoplasmFalse-negative diagnosesPatient ageSecondary malignanciesMetastatic carcinomaCell carcinomaPathology databaseMalignant neoplasmsFNAB diagnosisFNAB casesMalignant diagnosisMetastatic chordomaAncillary studiesNasopharyngeal carcinomaAspiration biopsyAncillary testsOlder men
2014
Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy
JIANG H, WANG H, WANG S, PEI Z, FU Z, FANG C, WANG J, LU Q, WANG E, LI J. Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy. Molecular Medicine Reports 2014, 11: 3523-3532. PMID: 25573098, DOI: 10.3892/mmr.2014.3141.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma of LungAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorDNA-Binding ProteinsDrug Resistance, NeoplasmEndonucleasesFemaleGene ExpressionHumansImmunohistochemistryKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedMyoD ProteinMyoglobinMyosin Type IIPlatinumPleural Effusion, MalignantPrognosisRibonucleoside Diphosphate ReductaseThymidylate SynthaseTubulinTumor Suppressor ProteinsConceptsExcision repair cross-complementing gene 1Expression of ERCC1Platinum-based chemotherapyMetastatic lung adenocarcinomaLung adenocarcinomaPleural effusionLung Adenocarcinoma Pleural EffusionsPlatinum-based chemotherapy treatmentTumor cellsUntreated lung adenocarcinomasSurvival of patientsMalignant pleural effusionPleural fluid samplesExpression levelsProtein expression levelsWestern blot analysisClinical outcomesPatient survivalLung cancerChemotherapy treatmentLung carcinomaNon-muscle myosin IIPatientsAdenocarcinomaSurvival rateLearning curve for endobronchial ultrasound-guided transbronchial needle aspiration: Experience of a community-based teaching hospital
WANG H, D’CRUZ C, YAM D, DILLA L, TSANG P. Learning curve for endobronchial ultrasound-guided transbronchial needle aspiration: Experience of a community-based teaching hospital. Molecular Medicine Reports 2014, 10: 2441-2446. PMID: 25189939, DOI: 10.3892/mmr.2014.2533.Peer-Reviewed Original ResearchConceptsEndobronchial ultrasound-guided transbronchial needle aspirationUltrasound-guided transbronchial needle aspirationTransbronchial needle aspirationEBUS-TBNACell blocksTissue diagnosisNeedle aspirationHistological examinationTTF-1Community-based teaching hospitalAcid-fast bacilli stainMetastatic lung carcinomaSquamous cell carcinomaThyroid transcription factor-1KRAS mutation analysisSubsequent tissue diagnosisSufficient diagnostic materialCell block preparationsLymph nodesMetastatic adenocarcinomaMediastinal lymphomaCell carcinomaNodal stagingLung cancerTranscription factor 1