2021
Tumor suppressor p53 regulates intestinal type 2 immunity
Chang C, Wang J, Zhao Y, Liu J, Yang X, Yue X, Wang H, Zhou F, Inclan-Rico J, Ponessa J, Xie P, Zhang L, Siracusa M, Feng Z, Hu W. Tumor suppressor p53 regulates intestinal type 2 immunity. Nature Communications 2021, 12: 3371. PMID: 34099671, PMCID: PMC8184793, DOI: 10.1038/s41467-021-23587-x.Peer-Reviewed Original ResearchConceptsType 2 immunityRole of p53Parasitic infectionsInnate lymphoid cell responsesLymphoid cell responsesImmune integrityInfection of parasitesNippostrongylus brasiliensisTuft cellsCell responsesImmunityInfectionTritrichomonas murisTumor suppressor p53P53Unrecognized functionTumor suppressionSuppressor p53Critical triggerCritical roleCell circuitRoleResponse
2020
Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis
Li J, Huynh L, Cornwell WD, Tang MS, Simborio H, Huang J, Kosmider B, Rogers TJ, Zhao H, Steinberg MB, Thu Thi Le L, Zhang L, Pham K, Liu C, Wang H. Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2020, 41: 839-853. PMID: 33380174, PMCID: PMC8608030, DOI: 10.1161/atvbaha.120.315556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAtherosclerosisDisease Models, AnimalDNA DamageDNA, MitochondrialE-Cigarette VaporFemaleHumansInflammationInflammation MediatorsMacrophagesMaleMiceMice, Inbred C57BLMice, Knockout, ApoEMiddle AgedMitochondriaRAW 264.7 CellsSignal TransductionSmokersToll-Like Receptor 9VapingConceptsECV exposureTLR9 expressionInflammatory cytokinesClassical monocytesTLR9 activationAtherosclerotic plaquesEight-week-old ApoEUpregulation of TLR9Expression of TLR9Atherosclerotic lesion developmentOil Red O stainingToll-like receptorsDays/weekE-cig exposureMonocytes/macrophagesNormal laboratory dietRed O stainingPotential pharmacological targetElectronic cigarette useHours/dayProinflammatory cytokinesCig vaporPlasma levelsTLR9 antagonistTLR9 inhibitor
2013
SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion
Chen X, Wang H, Bajaj K, Zhang P, Meng Z, Ma D, Bai Y, Liu H, Adams E, Baines A, Yu G, Sartor M, Zhang B, Yi Z, Lin J, Young S, Schekman R, Ginsburg D. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. ELife 2013, 2: e00444. PMID: 23580231, PMCID: PMC3622177, DOI: 10.7554/elife.00444.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins ECell Line, TumorCholesterolCOP-Coated VesiclesDown-RegulationDyslipidemiasEndoplasmic ReticulumEpistasis, GeneticGenotypeHEK293 CellsHumansLiverMice, 129 StrainMice, Inbred C57BLMice, KnockoutMutationPhenotypeProprotein Convertase 9Proprotein ConvertasesProtein TransportReceptors, LDLSerine EndopeptidasesTransfectionVesicular Transport ProteinsConceptsEndoplasmic reticulumCOPII vesicle formationCargo recruitmentCOPII vesiclesCargo proteinsEukaryotic cellsCargo selectivitySecretory pathwaySEC24AEfficient exitUnappreciated heterogeneityNegative regulatorSecretory proteinsVesicle formationPCSK9 secretionComplete genetic deficiencyGenetic deficiencyLDLR levelsProteinVesiclesFundamental roleNormal survivalPartial overlapRecruitmentSEC24B
2012
SEC23B is required for the maintenance of murine professional secretory tissues
Tao J, Zhu M, Wang H, Afelik S, Vasievich M, Chen X, Zhu G, Jensen J, Ginsburg D, Zhang B. SEC23B is required for the maintenance of murine professional secretory tissues. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: e2001-e2009. PMID: 22745161, PMCID: PMC3406820, DOI: 10.1073/pnas.1209207109.Peer-Reviewed Original ResearchMeSH KeywordsAlcian BlueAnimalsAnthraquinonesApoptosisEndoplasmic ReticulumFluorescent Antibody TechniqueHumansIn Situ Nick-End LabelingMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ImmunoelectronMutationPancreasReal-Time Polymerase Chain ReactionSecretory PathwaySpecies SpecificityVesicular Transport ProteinsConceptsEndoplasmic reticulumSecretory tissueSpecies-specific shiftsGTPase-activating proteinsUnfolded protein responseAccumulation of proteinsSimilar ultrastructural alterationsAbundant cargoCargo recognitionEukaryotic cellsSar1 GTPaseER exitER lumenSecretory pathwayTissue-specific dependenceProtein responseHypomorphic mutationsSecretory proteinsSEC23BDisparate phenotypesCOPIICongenital dyserythropoietic anemia type IIEmbryonic pancreasAnemia phenotypeProapoptotic pathways