2020
Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis
Li J, Huynh L, Cornwell WD, Tang MS, Simborio H, Huang J, Kosmider B, Rogers TJ, Zhao H, Steinberg MB, Thu Thi Le L, Zhang L, Pham K, Liu C, Wang H. Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2020, 41: 839-853. PMID: 33380174, PMCID: PMC8608030, DOI: 10.1161/atvbaha.120.315556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAtherosclerosisDisease Models, AnimalDNA DamageDNA, MitochondrialE-Cigarette VaporFemaleHumansInflammationInflammation MediatorsMacrophagesMaleMiceMice, Inbred C57BLMice, Knockout, ApoEMiddle AgedMitochondriaRAW 264.7 CellsSignal TransductionSmokersToll-Like Receptor 9VapingConceptsECV exposureTLR9 expressionInflammatory cytokinesClassical monocytesTLR9 activationAtherosclerotic plaquesEight-week-old ApoEUpregulation of TLR9Expression of TLR9Atherosclerotic lesion developmentOil Red O stainingToll-like receptorsDays/weekE-cig exposureMonocytes/macrophagesNormal laboratory dietRed O stainingPotential pharmacological targetElectronic cigarette useHours/dayProinflammatory cytokinesCig vaporPlasma levelsTLR9 antagonistTLR9 inhibitorPulmonary vasculopathy in explanted lungs from patients with interstitial lung disease undergoing lung transplantation
Dotan Y, Stewart J, Gangemi A, Wang H, Aneja A, Chakraborty B, Dass C, Zhao H, Marchetti N, D'Alonzo G, Cordova FC, Criner G, Mamary AJ. Pulmonary vasculopathy in explanted lungs from patients with interstitial lung disease undergoing lung transplantation. BMJ Open Respiratory Research 2020, 7: e000532. PMID: 32661103, PMCID: PMC7359183, DOI: 10.1136/bmjresp-2019-000532.Peer-Reviewed Original ResearchConceptsFibrotic interstitial lung diseaseMean pulmonary artery pressureRight heart catheterisationInterstitial lung diseaseAdvanced fibrotic interstitial lung diseasesPulmonary arterial vasculopathySevere pulmonary hypertensionPulmonary hypertensionArterial vasculopathyLung transplantationLung diseaseEnd-stage interstitial lung diseaseSeverity of PHModerate pulmonary hypertensionPulmonary artery pressureIdiopathic pulmonary hypertensionIdiopathic pulmonary fibrosisHuman lung tissueArtery pressureHeart catheterisationPlexiform lesionsAdult patientsIntimal fibrosisPulmonary fibrosisLung diffusion
2019
Application of the Milan System for Reporting Submandibular Gland Cytopathology: An international, multi‐institutional study
Maleki Z, Baloch Z, Lu R, Shafique K, Song SJ, Viswanathan K, Rao RA, Lefler H, Fatima A, Wiles A, Jo VY, Wang H, Fadda G, Powers CN, Ali SZ, Pantanowitz L, Siddiqui MT, Nayar R, Klijanienko J, Barkan GA, Krane JF, Rossi ED, Callegari F, Kholová I, Bongiovanni M, Faquin WC, Pusztaszeri MP. Application of the Milan System for Reporting Submandibular Gland Cytopathology: An international, multi‐institutional study. Cancer Cytopathology 2019, 127: 306-315. PMID: 31050186, PMCID: PMC7404554, DOI: 10.1002/cncy.22135.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overAlgorithmsBiopsy, Fine-NeedleChildChild, PreschoolCytodiagnosisFemaleFollow-Up StudiesHealth FacilitiesHumansInfantInternational AgenciesMaleMedical RecordsMiddle AgedPrecancerous ConditionsRetrospective StudiesRisk AssessmentSalivary Gland NeoplasmsSubmandibular GlandYoung AdultThe Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outcomes: An Institutional Experience, Systematic Review, and Meta-analysis
Luo X, Khurana JS, Jhala N, Zhao H, Wang H. The Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outcomes: An Institutional Experience, Systematic Review, and Meta-analysis. Archives Of Pathology & Laboratory Medicine 2019, 143: 1012-1021. PMID: 30702333, DOI: 10.5858/arpa.2017-0582-ra.Peer-Reviewed Original ResearchConceptsProstatic acinar adenocarcinomaAdverse outcomesCribriform lesionsAcinar adenocarcinomaInstitutional experienceObservational retrospective case-control studySystematic reviewProstate-specific antigen (PSA) recurrenceRetrospective case-control studyRegional lymph node metastasisBiochemical prostate-specific antigen recurrenceDisease-specific deathProspective cohort studyLymph node metastasisCase-control studySeminal vesicle invasionCohort studyLocal recurrenceNode metastasisPoor outcomeExtraprostatic extensionStudy qualityMeta-AnalysisLesionsOutcomes
2018
Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema
Cornwell WD, Kim C, Lastra AC, Dass C, Bolla S, Wang H, Zhao H, Ramsey FV, Marchetti N, Rogers TJ, Criner GJ. Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema. Biomarkers 2018, 24: 232-239. PMID: 30411980, PMCID: PMC6509019, DOI: 10.1080/1354750x.2018.1542458.Peer-Reviewed Original ResearchConceptsInterstitial pulmonary fibrosisInflammatory profilePulmonary fibrosisLung tissueInflammatory proteinDistinct inflammatory profilesCohort of patientsCombined pulmonary fibrosisDistinct inflammatory processesEmphysematous lung tissueInflammatory protein levelsExplanted LungsInflammatory signatureInflammatory processDisease processEmphysemaPatientsEmphysematous tissueFibrosisLungProtein levelsTissue sectionsCPFETissueTissue extracts
2017
“Suspicious” salivary gland FNA: Risk of malignancy and interinstitutional variability
Maleki Z, Miller JA, Arab SE, Fadda G, Bo P, Wise O, Rossi ED, Jhala N, Ashish C, Ali SZ, Wang H. “Suspicious” salivary gland FNA: Risk of malignancy and interinstitutional variability. Cancer Cytopathology 2017, 126: 94-100. PMID: 29053216, DOI: 10.1002/cncy.21939.Peer-Reviewed Original ResearchConceptsRisk of malignancySalivary gland FNAsFNA specimensExact testSuspicious casesFine needle aspiration cytologyEpithelial metaplastic changesSignificant interinstitutional variabilityTertiary medical centerFisher's exact testSalivary gland neoplasmsSalivary gland lesionsSFM categoryMetaplastic changesMalignancy categoryConclusive diagnosisMalignant tumorsAspiration cytologyMedical CenterFNA casesIndeterminate resultsSFM groupGland neoplasmsSpecific neoplasmsGland lesions“Atypical” salivary gland fine needle aspiration: Risk of malignancy and interinstitutional variability
Wang H, Malik A, Maleki Z, Rossi ED, Ping B, Chandra A, Ali SZ, Fadda G, Wang J, Arab SE, Zhao H, Jhala N. “Atypical” salivary gland fine needle aspiration: Risk of malignancy and interinstitutional variability. Diagnostic Cytopathology 2017, 45: 1088-1094. PMID: 28960946, DOI: 10.1002/dc.23826.Peer-Reviewed Original ResearchConceptsRisk of malignancyFine-needle aspirationSalivary gland fine-needle aspirationMalignant tumorsNeedle aspirationTertiary medical centerSalivary gland lesionsHistological resectionSalivary Gland CytopathologyBenign tumorsMedical CenterAtypical diagnosisBenign neoplasmsBenign lesionsFNA yieldGland lesionsInterinstitutional variabilityDiagnostic categoriesMorphologic heterogeneityDiagnosisTumorsMilan SystemVariable practiceMalignancyLesions
2016
FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases
Wang H, Hoda R, Faquin W, Rossi E, Hotchandani N, Sun T, Pusztaszeri M, Bizzarro T, Bongiovanni M, Patel V, Jhala N, Fadda G, Gong Y. FNA biopsy of secondary nonlymphomatous malignancies in salivary glands: A multi‐institutional study of 184 cases. Cancer Cytopathology 2016, 125: 91-103. PMID: 28001329, DOI: 10.1002/cncy.21798.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsySquamous cell carcinomaDefinitive diagnosisDiagnostic challengeMetastatic squamous cell carcinomaDefinitive malignant diagnosisMean patient ageSalivary glandsCommon malignant neoplasmFalse-negative diagnosesPatient ageSecondary malignanciesMetastatic carcinomaCell carcinomaPathology databaseMalignant neoplasmsFNAB diagnosisFNAB casesMalignant diagnosisMetastatic chordomaAncillary studiesNasopharyngeal carcinomaAspiration biopsyAncillary testsOlder menAnterior Leaflet Augmentation With CorMatrix Porcine Extracellular Matrix in Twenty-Five Patients: Unexpected Patch Failures and Histologic Analysis
Kelley T, Kashem M, Wang H, McCarthy J, Carroll N, Moser G, Guy T. Anterior Leaflet Augmentation With CorMatrix Porcine Extracellular Matrix in Twenty-Five Patients: Unexpected Patch Failures and Histologic Analysis. The Annals Of Thoracic Surgery 2016, 103: 114-120. PMID: 27623276, DOI: 10.1016/j.athoracsur.2016.05.090.Peer-Reviewed Original ResearchConceptsAnterior leaflet augmentationSevere mitral regurgitationMitral regurgitationLeaflet augmentationLate deathsAutologous pericardiumECM patchPorcine extracellular matrixType of MRChronic obstructive pulmonary diseaseLower body mass indexFollow-up echocardiogramChronic renal failureObstructive pulmonary diseaseSubset of patientsVentricular ejection fractionBody mass indexSuture line dehiscenceResult of complicationsCorMatrix Extracellular MatrixTemple University HospitalDa Vinci surgical robotExtracellular matrixCause 7Chart review
2014
Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy
JIANG H, WANG H, WANG S, PEI Z, FU Z, FANG C, WANG J, LU Q, WANG E, LI J. Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy. Molecular Medicine Reports 2014, 11: 3523-3532. PMID: 25573098, DOI: 10.3892/mmr.2014.3141.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma of LungAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorDNA-Binding ProteinsDrug Resistance, NeoplasmEndonucleasesFemaleGene ExpressionHumansImmunohistochemistryKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedMyoD ProteinMyoglobinMyosin Type IIPlatinumPleural Effusion, MalignantPrognosisRibonucleoside Diphosphate ReductaseThymidylate SynthaseTubulinTumor Suppressor ProteinsConceptsExcision repair cross-complementing gene 1Expression of ERCC1Platinum-based chemotherapyMetastatic lung adenocarcinomaLung adenocarcinomaPleural effusionLung Adenocarcinoma Pleural EffusionsPlatinum-based chemotherapy treatmentTumor cellsUntreated lung adenocarcinomasSurvival of patientsMalignant pleural effusionPleural fluid samplesExpression levelsProtein expression levelsWestern blot analysisClinical outcomesPatient survivalLung cancerChemotherapy treatmentLung carcinomaNon-muscle myosin IIPatientsAdenocarcinomaSurvival rateFine‐needle aspiration biopsy of secondary neoplasms of the thyroid gland: A multi‐institutional study of 62 cases
Pusztaszeri M, Wang H, Cibas ES, Powers CN, Bongiovanni M, Ali S, Khurana KK, Michaels PJ, Faquin WC. Fine‐needle aspiration biopsy of secondary neoplasms of the thyroid gland: A multi‐institutional study of 62 cases. Cancer Cytopathology 2014, 123: 19-29. PMID: 25369542, DOI: 10.1002/cncy.21494.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsySquamous cell carcinomaThyroid fine-needle aspiration biopsySecondary neoplasmsAncillary studiesAspiration biopsyThyroid glandAccuracy of FNABMean patient ageMean tumor sizeUnknown primary siteUseful ancillary studiesMulti-institutional studyPatient ageInitial diagnosisTumor sizeCell carcinomaClinical historyPrimary tumorMedical recordsDiagnostic difficultiesMean intervalCystic carcinomaPrimary siteAdenocarcinomaLearning curve for endobronchial ultrasound-guided transbronchial needle aspiration: Experience of a community-based teaching hospital
WANG H, D’CRUZ C, YAM D, DILLA L, TSANG P. Learning curve for endobronchial ultrasound-guided transbronchial needle aspiration: Experience of a community-based teaching hospital. Molecular Medicine Reports 2014, 10: 2441-2446. PMID: 25189939, DOI: 10.3892/mmr.2014.2533.Peer-Reviewed Original ResearchConceptsEndobronchial ultrasound-guided transbronchial needle aspirationUltrasound-guided transbronchial needle aspirationTransbronchial needle aspirationEBUS-TBNACell blocksTissue diagnosisNeedle aspirationHistological examinationTTF-1Community-based teaching hospitalAcid-fast bacilli stainMetastatic lung carcinomaSquamous cell carcinomaThyroid transcription factor-1KRAS mutation analysisSubsequent tissue diagnosisSufficient diagnostic materialCell block preparationsLymph nodesMetastatic adenocarcinomaMediastinal lymphomaCell carcinomaNodal stagingLung cancerTranscription factor 1Follow-up of breast papillary lesion on core needle biopsy: experience in African-American population
Wang H, Tsang P, D’Cruz C, Clarke K. Follow-up of breast papillary lesion on core needle biopsy: experience in African-American population. Diagnostic Pathology 2014, 9: 86. PMID: 24762090, PMCID: PMC4039081, DOI: 10.1186/1746-1596-9-86.Peer-Reviewed Original ResearchConceptsCore needle biopsyBreast papillary lesionsIntraductal papillary carcinomaBenign papillary lesionsInvasive papillary carcinomaPapillary lesionsPapillary carcinomaNeedle biopsyAfrican American populationAfrican-American urban populationRate of upgradeAtypical papillary lesionsMalignant papillary lesionsLumpectomy/mastectomyResultsA totalPatient populationCore biopsyFollow-upEarly excisionAtypical lesionsLesion casesBiopsyCarcinomaLesionsLumpectomy
2011
Giant cell aortitis of the ascending aorta without signs or symptoms of systemic vasculitis is associated with elevated risk of distal aortic events
Wang H, Smith R, Spooner A, Isselbacher E, Cambria R, MacGillivray T, Stone J, Stone J. Giant cell aortitis of the ascending aorta without signs or symptoms of systemic vasculitis is associated with elevated risk of distal aortic events. Arthritis & Rheumatism 2011, 64: 317-319. PMID: 21953530, DOI: 10.1002/art.33343.Peer-Reviewed Original ResearchCase 11-2011 — A 47-Year-Old Man with Systemic Lupus Erythematosus and Heart Failure
Cabot R, Harris N, Shepard J, Rosenberg E, Cort A, Ebeling S, Peters C, Newton-Cheh C, Lin A, Baggish A, Wang H. Case 11-2011 — A 47-Year-Old Man with Systemic Lupus Erythematosus and Heart Failure. New England Journal Of Medicine 2011, 364: 1450-1460. PMID: 21488768, DOI: 10.1056/nejmcpc1011319.Peer-Reviewed Original Research