2022
Emerging Trends in the Pathological Research of Human Papillomavirus-positive Oropharyngeal Squamous Cell Carcinoma
Crane J, Shi Q, Xi Y, Lai J, Pham K, Wang H. Emerging Trends in the Pathological Research of Human Papillomavirus-positive Oropharyngeal Squamous Cell Carcinoma. Journal Of Clinical And Translational Pathology 2022, 2: 31-36. PMID: 36275841, PMCID: PMC9585478, DOI: 10.14218/jctp.2022.00004.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaSquamous cell carcinomaCell carcinomaHuman papillomavirusHuman papillomavirus-positive oropharyngeal squamous cell carcinomaHPV-positive oropharyngeal squamous cell carcinomaHPV-negative oropharyngeal squamous cell carcinomaActive human papillomavirusNew targetsLong-term survivalPotential new targetsDefinitive treatmentHPV 16Treatment optionsSurvival prognosisTumor prognosisAdvanced stageHealth responsePrecision treatmentPrecision medicinePatientsCarcinomaPrognosisTreatmentPathological research
2021
Tumor suppressor p53 regulates intestinal type 2 immunity
Chang C, Wang J, Zhao Y, Liu J, Yang X, Yue X, Wang H, Zhou F, Inclan-Rico J, Ponessa J, Xie P, Zhang L, Siracusa M, Feng Z, Hu W. Tumor suppressor p53 regulates intestinal type 2 immunity. Nature Communications 2021, 12: 3371. PMID: 34099671, PMCID: PMC8184793, DOI: 10.1038/s41467-021-23587-x.Peer-Reviewed Original ResearchConceptsType 2 immunityRole of p53Parasitic infectionsInnate lymphoid cell responsesLymphoid cell responsesImmune integrityInfection of parasitesNippostrongylus brasiliensisTuft cellsCell responsesImmunityInfectionTritrichomonas murisTumor suppressor p53P53Unrecognized functionTumor suppressionSuppressor p53Critical triggerCritical roleCell circuitRoleResponseConstructing an Efficient Bacillus subtilis Spore Display by Using Cohesin-Dockerin Interactions.
Wang H, Jiang X, Qian Y, Yin L. Constructing an Efficient Bacillus subtilis Spore Display by Using Cohesin-Dockerin Interactions. Molecules (Basel, Switzerland) 2021, 26 PMID: 33672137, PMCID: PMC7926950, DOI: 10.3390/molecules26041186.Peer-Reviewed Original Research
2020
Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis
Li J, Huynh L, Cornwell WD, Tang MS, Simborio H, Huang J, Kosmider B, Rogers TJ, Zhao H, Steinberg MB, Thu Thi Le L, Zhang L, Pham K, Liu C, Wang H. Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2020, 41: 839-853. PMID: 33380174, PMCID: PMC8608030, DOI: 10.1161/atvbaha.120.315556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAtherosclerosisDisease Models, AnimalDNA DamageDNA, MitochondrialE-Cigarette VaporFemaleHumansInflammationInflammation MediatorsMacrophagesMaleMiceMice, Inbred C57BLMice, Knockout, ApoEMiddle AgedMitochondriaRAW 264.7 CellsSignal TransductionSmokersToll-Like Receptor 9VapingConceptsECV exposureTLR9 expressionInflammatory cytokinesClassical monocytesTLR9 activationAtherosclerotic plaquesEight-week-old ApoEUpregulation of TLR9Expression of TLR9Atherosclerotic lesion developmentOil Red O stainingToll-like receptorsDays/weekE-cig exposureMonocytes/macrophagesNormal laboratory dietRed O stainingPotential pharmacological targetElectronic cigarette useHours/dayProinflammatory cytokinesCig vaporPlasma levelsTLR9 antagonistTLR9 inhibitorClassify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: machine learning versus multinomial models.
Deng F, Shen L, Wang H, Zhang L. Classify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: machine learning versus multinomial models. American Journal Of Cancer Research 2020, 10: 4624-4639. PMID: 33415023, PMCID: PMC7783755.Peer-Reviewed Original ResearchCytogenetic and molecular landscape and its potential clinical significance in Hispanic CMML patients from Puerto Rico
Jiang Z, Sun X, Wu Z, Alhatem A, Zheng R, Liu D, Wang Y, Kumar D, Xia C, You B, Wang H, Liu C, Jiang JG. Cytogenetic and molecular landscape and its potential clinical significance in Hispanic CMML patients from Puerto Rico. Oncotarget 2020, 11: 4411-4420. PMID: 33315966, PMCID: PMC7720771, DOI: 10.18632/oncotarget.27824.Peer-Reviewed Original ResearchCMML patientsChronic myelomonocytic leukemiaFavorable prognosisClinical significanceMolecular landscapePossible clinical significancePotential clinical significanceClonal hematopoietic neoplasmsMyeloproliferative characteristicsUnfavorable prognosisPathological featuresMyelomonocytic leukemiaPatientsTrisomy 8Abnormal karyotypeCytogenetic abnormalitiesHematopoietic neoplasmsPrognosisRacial disparitiesGene mutationsLower ratesHigh rateProfile testPuerto RicoPrevious studiesThe Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy
Liu D, Badeti S, Dotti G, Jiang JG, Wang H, Dermody J, Soteropoulos P, Streck D, Birge RB, Liu C. The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy. Cell Communication And Signaling 2020, 18: 134. PMID: 32843053, PMCID: PMC7446110, DOI: 10.1186/s12964-020-00617-7.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor (CAR) immunotherapyCAR immunotherapyCancer immunotherapyClinical outcomesImmune cellsImmunological synapseCancer therapyPrecision cancer immunotherapyRefractory blood cancersRecent clinical trialsTumor antigen specificityUnique cell surface receptorChimeric antigen receptorImmune cell activationAdoptive transferImmunotherapeutic strategiesSuppressor cellsClinical predictorsCell immunotherapyClinical trialsIndividual patientsImmunotherapyAntigen specificityCell activationBlood cancersE-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1
Pham K, Huynh D, Le L, Delitto D, Yang L, Huang J, Kang Y, Steinberg MB, Li J, Zhang L, Liu D, Tang MS, Liu C, Wang H. E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1. Cancer Letters 2020, 491: 132-145. PMID: 32829009, PMCID: PMC9703643, DOI: 10.1016/j.canlet.2020.08.010.Peer-Reviewed Original ResearchConceptsBC cell growthCig exposureLung metastasesBreast cancerVCAM-1V-CAM-1Role of CCL5Upregulated protein expressionBC cell survivalE-cig exposurePro-tumorigenic factorsBC cell apoptosisBreast carcinoma progressionMetastatic lung colonizationCCR5 axisMFP tumorsTAMs infiltrationInfiltrated macrophagesCell growthCo-culture systemImmunohistochemical stainsCell crosstalkBC cellsBC growthProliferation indexIatrogenic Cholesteatoma Presenting as Neck Mass
Vella JB, Wackym PA, Wang H, Roychowdhury ST. Iatrogenic Cholesteatoma Presenting as Neck Mass. The Laryngoscope 2020, 131: e882-e884. PMID: 32770806, DOI: 10.1002/lary.28941.Peer-Reviewed Original ResearchElectronic cigarettes promotes the lung colonization of human breast cancer in NOD-SCID-Gamma mice.
Huynh D, Huang J, Le LTT, Liu D, Liu C, Pham K, Wang H. Electronic cigarettes promotes the lung colonization of human breast cancer in NOD-SCID-Gamma mice. International Journal Of Clinical And Experimental Pathology 2020, 13: 2075-2081. PMID: 32922603, PMCID: PMC7476960.Peer-Reviewed Original ResearchE-cigsNOD-SCIDGamma miceTumor cellsCig vapour extractElectronic cigarette smokingHuman breast cancer cell line MDA-MB-231Breast cancer cell line MDA-MB-231Cancer cell line MDA-MB-231Human breast cancer cellsCell line MDA-MB-231E-cig exposureHuman breast cancerMetastasis-promoting effectsTail vein injectionBreast cancer cellsTumor cell proliferationMDA-MB-231Tumor cell apoptosisCig exposureCigarette smokingLung metastasesTumor loadTumor mortalityBreast cancerLIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome
Wang H, Wang J, Zhao Y, Zhang X, Liu J, Zhang C, Haffty B, Verzi M, Zhang L, Gao N, Feng Z, Hu W. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death & Disease 2020, 11: 588. PMID: 32719388, PMCID: PMC7385639, DOI: 10.1038/s41419-020-02790-6.Peer-Reviewed Original ResearchConceptsRadiation-induced GI syndromeLeukemia inhibitory factorIntestinal epitheliumIntestinal stem cellsLIF deficiencyGI syndromeGastrointestinal syndromeFunction of ISCsRadiation-induced gastrointestinal syndromeRecombinant leukemia inhibitory factorRecombinant LIFWild-type miceISC functionLifespan of miceAkt/GSK3βIntestinal epithelial regenerationIntestinal epithelial homeostasisStem cellsProlong survivalWT miceAdult intestinal epitheliumRadioprotective roleΒ-catenin activityCytokine essentialHigh dosesPulmonary vasculopathy in explanted lungs from patients with interstitial lung disease undergoing lung transplantation
Dotan Y, Stewart J, Gangemi A, Wang H, Aneja A, Chakraborty B, Dass C, Zhao H, Marchetti N, D'Alonzo G, Cordova FC, Criner G, Mamary AJ. Pulmonary vasculopathy in explanted lungs from patients with interstitial lung disease undergoing lung transplantation. BMJ Open Respiratory Research 2020, 7: e000532. PMID: 32661103, PMCID: PMC7359183, DOI: 10.1136/bmjresp-2019-000532.Peer-Reviewed Original ResearchConceptsFibrotic interstitial lung diseaseMean pulmonary artery pressureRight heart catheterisationInterstitial lung diseaseAdvanced fibrotic interstitial lung diseasesPulmonary arterial vasculopathySevere pulmonary hypertensionPulmonary hypertensionArterial vasculopathyLung transplantationLung diseaseEnd-stage interstitial lung diseaseSeverity of PHModerate pulmonary hypertensionPulmonary artery pressureIdiopathic pulmonary hypertensionIdiopathic pulmonary fibrosisHuman lung tissueArtery pressureHeart catheterisationPlexiform lesionsAdult patientsIntimal fibrosisPulmonary fibrosisLung diffusionTrends and Prediction in Daily New Cases and Deaths of COVID-19 in the United States: An Internet Search-Interest Based Model
Yuan X, Xu J, Hussain S, Wang H, Gao N, Zhang L. Trends and Prediction in Daily New Cases and Deaths of COVID-19 in the United States: An Internet Search-Interest Based Model. Exploratory Research And Hypothesis In Medicine 2020, 5: 1-6. PMID: 32348380, PMCID: PMC7176069, DOI: 10.14218/erhm.2020.00023.Peer-Reviewed Original ResearchCytologic grading of primary malignant salivary gland tumors: A blinded review by an international panel
Johnson DN, Onenerk M, Krane JF, Rossi ED, Baloch Z, Barkan G, Bongiovanni M, Callegari F, Canberk S, Dixon G, Field A, Griffith CC, Jhala N, Jiang S, Kurtycz D, Layfield L, Lin O, Maleki Z, Perez‐Machado M, Pusztaszeri M, Vielh P, Wang H, Zarka MA, Faquin WC. Cytologic grading of primary malignant salivary gland tumors: A blinded review by an international panel. Cancer Cytopathology 2020, 128: 392-402. PMID: 32267606, PMCID: PMC7413070, DOI: 10.1002/cncy.22271.Peer-Reviewed Original ResearchConceptsSalivary gland carcinomasFine-needle aspirationPrimary salivary gland carcinomaSalivary gland tumorsTumor gradeMedical CenterSGC casesGland tumorsPrimary malignant salivary gland tumorsHigh-grade salivary gland carcinomasMalignant salivary gland tumorsTertiary medical centerSalivary duct carcinomaCorresponding resection specimensAcinic cell carcinomaEpithelial-myoepithelial carcinomaAcademic medical centerSalivary gland fine-needle aspirationPreoperative evaluationStudy cohortDuct carcinomaCell carcinomaHistologic diagnosisHistopathologic examinationInternational panelThe role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
Brown M, Zhang W, Yan D, Kenath R, Le L, Wang H, Delitto D, Ostrov D, Robertson K, Liu C, Pham K. The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC. PLOS ONE 2020, 15: e0226917. PMID: 31929540, PMCID: PMC6957139, DOI: 10.1371/journal.pone.0226917.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaTypes of cancerDuctal adenocarcinomaSurvivin expressionSurvivin inhibitorClinical response rateNovel survivin inhibitorHalf of patientsElevated survivin expressionLower patient survivalPancreatic tumor microenvironmentPotential therapeutic targetExpression of survivinRole of survivinField of oncologyPancreatic cancer linesImmunotherapeutic approachesPatient survivalUntreated cohortTherapeutic responseInhibitor of survivinTreatment resistancePDAC progressionEffective treatmentTumor cell migration
2019
Salivary Gland
Jiang H, Arbzadeh E, Gong Y, Wang H. Salivary Gland. Practical Anatomic Pathology 2019, 225-244. DOI: 10.1007/978-3-030-24059-2_14.Peer-Reviewed Original ResearchSalivary gland tumorsFine-needle aspirationGland tumorsSalivary Gland CytopathologyCytomorphological featuresCystic lesionsDifferential diagnosisFNA diagnosisAncillary testsWorld Health Organization classificationPrimary salivary gland tumorsSalivary glandsTissue microarray studyAdequate tissue samplingMilan SystemSufficient diagnostic materialSalivary gland lesionsSalivary gland massesPatient ageClinical symptomsHistological typeOrganization classificationCommon subtypeMetastatic tumorsNeck surgeonsLiver Cytopathology
Zhou J, Wang H, Jhala N. Liver Cytopathology. Practical Anatomic Pathology 2019, 269-281. DOI: 10.1007/978-3-030-24059-2_16.Peer-Reviewed Original ResearchFine-needle aspirationHepatocellular carcinomaLiver fine-needle aspirationParticular diagnostic challengeCharacteristic cytomorphological featuresPrimary hepatocellular carcinomaCommon diagnostic dilemmaTumor cell groupsFocal liver lesionsIdentification of endotheliumMetastatic carcinomaDiagnostic challengeDiagnostic dilemmaMetastatic tumorsNormal cellular componentsNeedle aspirationLiver lesionsCytomorphological featuresAccurate diagnosisDiagnostic approachCell groupsTumor cellsNormal counterpartsCarcinomaTumorsProblems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study
Shih AR, Uruga H, Bozkurtlar E, Chung J, Hariri LP, Minami Y, Wang H, Yoshizawa A, Muzikansky A, Moreira AL, Mino‐Kenudson M. Problems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study. Histopathology 2019, 75: 649-659. PMID: 31107973, DOI: 10.1111/his.13922.Peer-Reviewed Original ResearchConceptsSmall lung adenocarcinomaInvasive adenocarcinomaLung adenocarcinomaLung pathologistsElastic stainInterobserver agreementHigh-grade cytologyLow-grade cytologyInvasive component sizeReproducibility of classificationHistological patternFinal diagnosisInvasive componentAdenocarcinomaConsensus conferenceRoutine assessmentInterobserver studyInconsistent classificationPredominant patternSingle caseKappa valuesCytologyPathologistsPrimary salivary gland‐type tumors of the tracheobronchial tree diagnosed by transbronchial fine needle aspiration: Clinical and cytomorphologic features with histopathologic correlation
Doxtader EE, Shah AA, Zhang Y, Wang H, Dyhdalo KS, Farver C. Primary salivary gland‐type tumors of the tracheobronchial tree diagnosed by transbronchial fine needle aspiration: Clinical and cytomorphologic features with histopathologic correlation. Diagnostic Cytopathology 2019, 47: 1168-1176. PMID: 31343850, DOI: 10.1002/dc.24285.Peer-Reviewed Original ResearchConceptsSalivary gland-type tumorsTransbronchial fine needle aspirationPrimary salivary gland-type tumorsFine-needle aspirationTracheobronchial treeSalivary gland tumorsNeedle aspirationCytomorphologic featuresGland tumorsSalivary gland-type neoplasmsPrimary salivary gland tumorsSurgical pathology specimenClear cell carcinomaCorresponding surgical specimenAdenoid cystic carcinomaEpithelial-myoepithelial carcinomaSurgical pathology specimensSalivary gland typeEndobronchial biopsyFrequent diagnosisStudy cohortLung massTracheal massCell carcinomaCytomorphologic changesThe Evolving Field of Cytopathology and Its Expanding Role in Pathologic Practice
Wang H, Jhala N. The Evolving Field of Cytopathology and Its Expanding Role in Pathologic Practice. Archives Of Pathology & Laboratory Medicine 2019, 143: 662-663. PMID: 31121108, DOI: 10.5858/arpa.2018-0530-ed.Peer-Reviewed Original Research