2023
Imaging metabolism of deuterated glucose in patients with primary brain tumors
Corbin Z, Liu Y, Fulbright R, Thaw-Poon S, Baehring J, Blondin N, Kim P, Omuro A, Chiang V, Moliterno J, Omay S, Piepmeier J, Rothman D, de Graaf R, De Feyter H. Imaging metabolism of deuterated glucose in patients with primary brain tumors. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0142.Peer-Reviewed Original ResearchRobust and Automated Processing of Deuterium Metabolic Imaging (DMI) using Spatial Prior Knowledge
de Graaf R, Liu Y, Corbin Z, De Feyter H. Robust and Automated Processing of Deuterium Metabolic Imaging (DMI) using Spatial Prior Knowledge. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/4107.Peer-Reviewed Original ResearchIndirect detection of deuterated glucose brain metabolism at 3 Tesla: preliminary findings in volunteers and patients with gliomas
Autry A, LaFontaine M, Villanueva-Meyer J, Chang S, de Feyter H, Li Y. Indirect detection of deuterated glucose brain metabolism at 3 Tesla: preliminary findings in volunteers and patients with gliomas. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/2502.Peer-Reviewed Original ResearchIndirect detectionMagnetic resonance spectroscopic imagingAnterior cingulate cortexSingle-voxel spectroscopyGlucose metabolismLevels of glutamateSpectroscopic imagingReduced levels of glutamateGlucose brain metabolismT2 lesionsHealthy subjectsCingulate cortexBrain tumorsTeslaPatientsBrain metabolismGray matterPreliminary dataReduced levelsMetabolismMapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)
Ip K, Thomas M, Behar K, de Graaf R, De Feyter H. Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI). Frontiers In Cellular Neuroscience 2023, 17: 1130816. PMID: 37187610, PMCID: PMC10175635, DOI: 10.3389/fncel.2023.1130816.Peer-Reviewed Original ResearchBrain tumorsNormal brainHigh tumorCholine uptakeRG2 cellsCholine infusionMetabolic imagingExogenous cholineMetabolic imaging techniquesDeuterium metabolic imagingIntravenous infusionRG2 tumorsTumor lesionsAnimal modelsCholine metabolismTumorsInfusionRat glioblastomaIntracellular cholineFree cholineHigh uptakeLesionsCholineRatsDeuterated choline
2018
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science Advances 2018, 4: eaat7314. PMID: 30140744, PMCID: PMC6105304, DOI: 10.1126/sciadv.aat7314.Peer-Reviewed Original ResearchConceptsOral intakeMetabolic imagingGlucose uptakeHigh-grade brain tumorsRat glioma modelPositron emission tomography (PET) detectionSimilar metabolic patternMetabolic imaging techniquesDeuterium metabolic imagingHigher glucose uptakeGlucose analog 2FDG-PETF-fluoroIntravenous infusionBrain tumorsGlioma modelGlucose metabolismNormal brainTomography detectionAnimal modelsMagnetic resonance spectroscopicTumor tissueHuman liverMetabolic patternsNoninvasive approach
2016
A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth
De Feyter HM, Behar KL, Rao JU, Madden-Hennessey K, Ip KL, Hyder F, Drewes LR, Geschwind JF, de Graaf RA, Rothman DL. A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth. Neuro-Oncology 2016, 18: 1079-1087. PMID: 27142056, PMCID: PMC4933488, DOI: 10.1093/neuonc/now088.Peer-Reviewed Original ResearchConceptsKetone body oxidationKetogenic dietKetone bodiesGlioma modelBrain tumorsBrain tumor metabolismCortical brain tissuePlasma glucose concentrationRat glioma modelRodent glioma modelsContralateral brainRat gliomaTumor growthBrain tissueTumor metabolismBeta-hydroxybutyrate oxidationTumor cellsGliomasMR spectroscopyTumor's abilityMonocarboxylate transportersDietGlucose concentrationKetone body transportTherapy