Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats
Lenaers E, De Feyter H, Hoeks J, Schrauwen P, Schaart G, Nabben M, Nicolay K, Prompers J, Hesselink M. Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats. Obesity 2010, 18: 1100-1107. PMID: 19875988, DOI: 10.1038/oby.2009.372.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAdenine Nucleotide Translocator 1AnimalsDiabetes Mellitus, ExperimentalHyperglycemiaHyperinsulinismIon ChannelsMaleMitochondria, MuscleMitochondrial ProteinsMuscle Fibers, SkeletalObesityOxidation-ReductionOxygen ConsumptionProtein CarbonylationRatsRats, ZuckerSeverity of Illness IndexUncoupling Protein 3ConceptsUncoupling protein 3Palmitoyl-CoAMitochondrial functionZucker diabetic fattyFat oxidative capacityReduced fat oxidative capacityProgressive development of insulin resistanceMitochondrial defectsDevelopment of insulin resistanceCarbonyl cyanide p-trifluoromethoxyphenylhydrazoneIntrinsic mitochondrial defectIntrinsic mitochondrial functionInsulin resistanceMitochondrial dysfunctionMuscle mitochondrial functionPyruvate oxidationMitochondrial adaptationsType 2 diabetesState 3Development of type 2 diabetesMitochondrial capacityProtein 3Fa/fa ratsP-trifluoromethoxyphenylhydrazonePyruvate