2017
Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex
De Feyter H, Herzog RI, Steensma BR, Klomp DWJ, Brown PB, Mason GF, Rothman DL, de Graaf R. Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex. Magnetic Resonance In Medicine 2017, 80: 11-20. PMID: 29134686, PMCID: PMC5876108, DOI: 10.1002/mrm.27003.Peer-Reviewed Original Research
2016
Detection of cerebral NAD+ in humans at 7T
de Graaf R, De Feyter H, Brown PB, Nixon TW, Rothman DL, Behar KL. Detection of cerebral NAD+ in humans at 7T. Magnetic Resonance In Medicine 2016, 78: 828-835. PMID: 27670385, PMCID: PMC5366282, DOI: 10.1002/mrm.26465.Peer-Reviewed Original Research
2013
Increased Brain Lactate Concentrations Without Increased Lactate Oxidation During Hypoglycemia in Type 1 Diabetic Individuals
De Feyter HM, Mason GF, Shulman GI, Rothman DL, Petersen KF. Increased Brain Lactate Concentrations Without Increased Lactate Oxidation During Hypoglycemia in Type 1 Diabetic Individuals. Diabetes 2013, 62: 3075-3080. PMID: 23715622, PMCID: PMC3749358, DOI: 10.2337/db13-0313.Peer-Reviewed Original ResearchConceptsBrain lactate concentrationBlood-brain barrierHypoglycemia unawarenessLactate concentrationT1D subjectsControl subjectsType 1 diabetic subjectsType 1 diabetic individualsBlood-borne lactateNondiabetic control subjectsPlasma lactate concentrationMonocarboxylic acid transportDiabetic subjectsHypoglycemic clampT1D patientsDiabetic individualsBrain metabolismBrain fuelBrain glutamateBrain energeticsHypoglycemiaPatientsMetabolic adaptationAcid transportSubjectsIncreased Brain Transport and Metabolism of Acetate in Hypoglycemia Unawareness
Gulanski BI, De Feyter HM, Page KA, Belfort-DeAguiar R, Mason GF, Rothman DL, Sherwin RS. Increased Brain Transport and Metabolism of Acetate in Hypoglycemia Unawareness. The Journal Of Clinical Endocrinology & Metabolism 2013, 98: 3811-3820. PMID: 23796565, PMCID: PMC4425818, DOI: 10.1210/jc.2013-1701.Peer-Reviewed Original ResearchConceptsHypoglycemia-associated autonomic failureHypoglycemia unawarenessT1DM individualsEpinephrine levelsBrain transportControl groupType 1 diabetes mellitusDefective glucose counterregulationHealthy nondiabetic controlsSevere hypoglycemia unawarenessIntensive insulin therapyLong-term complicationsHospital research unitEntire study populationT1DM participantsAutonomic failureGlucose counterregulationInsulin therapyDiabetes mellitusNondiabetic controlsCerebral cortexAcute hypoglycemiaT1DM controlsCerebral energeticsStudy population