2020
Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing
Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing. Regenerative Medicine 2020, 15: 1277-1293. PMID: 32228292, PMCID: PMC7304438, DOI: 10.2217/rme-2019-0086.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsMuscle cellsDiabetic wound healingWound healingPro-angiogenic cytokinesMurine AdiposeStem cellsType macrophagesCollagen scaffoldsCultured mediumM2-type macrophagesCellsNumber of totalNew candidatesAngiogenesisNude miceDiabetic woundsPromising new candidateScaffoldsHealingCytokinesExpressionSecreteWoundsAdipose
2019
The potential and limitations of induced pluripotent stem cells to achieve wound healing
Gorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, Isaji T, Ono S, Liu S, Lee SR, Xu J, Liu J, Taniguchi R, Yastula B, Hsia HC, Qyang Y, Dardik A. The potential and limitations of induced pluripotent stem cells to achieve wound healing. Stem Cell Research & Therapy 2019, 10: 87. PMID: 30867069, PMCID: PMC6416973, DOI: 10.1186/s13287-019-1185-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic woundsCell therapyStem cellsDiabetic foot ulcersCell typesWound healingInvasive harvesting techniquesAdult-derived stem cellsNormal skin architecturePluripotent stem cellsLimb ischemiaFoot ulcersLimited cell survivalSafety profileOnly cell typeAnimal modelsHuman studiesPotential treatmentPhysiologic responsesHealthy skinImmune rejectionAdvanced therapiesTranslational potentialUse of iPSCsSystemic factors