Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer
Chakraborty D, Benham V, Bullard B, Kearney T, Hsia HC, Gibbon D, Demireva EY, Lunt SY, Bernard JJ. Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Oncogene 2017, 36: 6668-6679. PMID: 28783178, PMCID: PMC5709202, DOI: 10.1038/onc.2017.278.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell Transformation, NeoplasticDiet, High-FatFemaleFibroblast Growth Factor 2HumansIntra-Abdominal FatMice, Inbred StrainsReceptor, Fibroblast Growth Factor, Type 1Signal TransductionConceptsAdipose tissueFibroblast growth factor-2 levelsGrowth factor-2 levelsFGFR-1Cancer prevention strategiesEpithelial cellsExcess adipose tissueTumor formationFactor 2 levelsVisceral adipose tissueNovel ex vivo systemSkin tumor formationObese human donorsNon-tumorigenic epithelial cellsSoft agarEx vivo systemGrowth factor receptorAdjuvant therapyEpithelial cell growthVisceral adiposityLevels of FGF2Obese individualsEpidemiological evidenceFibroblast growth factor receptorCancer risk