2022
Impact of radiotherapy delay following biopsy for patients with unresected glioblastoma.
Gao S, Jin L, Moliterno J, Corbin ZA, Bindra RS, Contessa JN, Yu JB, Park HS. Impact of radiotherapy delay following biopsy for patients with unresected glioblastoma. Journal Of Neurosurgery 2022, 138: 610-620. PMID: 35907197, DOI: 10.3171/2022.5.jns212761.Peer-Reviewed Original ResearchConceptsWeeks of biopsyOverall survivalCox proportional hazards regression modelingProportional hazards regression modelingNational Cancer DatabaseInitiation of radiotherapyKaplan-Meier methodWorse overall survivalWilcoxon rank sum testEffects of confoundersRank sum testUnresected diseaseAdjuvant radiotherapyConcurrent chemotherapyMedian intervalMultivariable analysisRadiotherapy delayCancer DatabaseClinical dataBiopsyPatientsLate initiationAggressive natureRadiotherapyPotential association
2019
Is Proton Therapy a “Pro” for Breast Cancer? A Comparison of Proton vs. Non-proton Radiotherapy Using the National Cancer Database
Chowdhary M, Lee A, Gao S, Wang D, Barry PN, Diaz R, Bagadiya NR, Park HS, Yu JB, Wilson LD, Moran MS, Higgins SA, Knowlton CA, Patel KR. Is Proton Therapy a “Pro” for Breast Cancer? A Comparison of Proton vs. Non-proton Radiotherapy Using the National Cancer Database. Frontiers In Oncology 2019, 8: 678. PMID: 30693271, PMCID: PMC6339938, DOI: 10.3389/fonc.2018.00678.Peer-Reviewed Original ResearchLymph node irradiationNational Cancer DatabaseOverall survivalMultivariable analysisBreast cancerCancer DatabaseProton radiotherapyNon-metastatic breast cancerCox proportional hazards modelHigher heart dosesN2-N3 diseaseMultivariate logistic analysisProportional hazards modelAcademic facilitiesLogistic regression modelsHeart dosesAdjuvant radiotherapyNode irradiationHazard ratioNode positivityClinical benefitClinical trialsPRT patientsStage 0Hazards model
2018
Clinical value of transoral robotic surgery: Nationwide results from the first 5 years of adoption
Li H, Torabi SJ, Park HS, Yarbrough WG, Mehra S, Choi R, Judson BL. Clinical value of transoral robotic surgery: Nationwide results from the first 5 years of adoption. The Laryngoscope 2018, 129: 1844-1855. PMID: 30575965, DOI: 10.1002/lary.27740.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Squamous CellChemoradiotherapy, AdjuvantChi-Square DistributionCombined Modality TherapyDatabases, FactualFemaleHumansKaplan-Meier EstimateMaleMargins of ExcisionMiddle AgedMultivariate AnalysisNatural Orifice Endoscopic SurgeryNeoplasm StagingOropharyngeal NeoplasmsProportional Hazards ModelsRegression AnalysisRetrospective StudiesRobotic Surgical ProceduresTreatment OutcomeUnited StatesConceptsOropharyngeal squamous cell carcinomaTransoral robotic surgeryTransoral laser microsurgeryNonrobotic surgeryTORS patientsPositive marginsTLM patientsLower likelihoodT2 oropharyngeal squamous cell carcinomaEarly stage oropharyngeal squamous cell carcinomaLong-term oncologic outcomesUse of TORSKaplan-Meier log-rank testRobotic surgeryNational Cancer DatabaseMajority of patientsMultivariate Cox analysisSquamous cell carcinomaLog-rank testChi-square testCox multivariateN3 diseaseAdjuvant chemoradiotherapyAdjuvant radiotherapyAdjuvant therapyAdjuvant Chemotherapy Is Associated With Improved Survival for Late‐Stage Salivary Squamous Cell Carcinoma
Cheraghlou S, Schettino A, Zogg CK, Otremba MD, Bhatia A, Park HS, Osborn HA, Mehra S, Yarbrough WG, Judson BL. Adjuvant Chemotherapy Is Associated With Improved Survival for Late‐Stage Salivary Squamous Cell Carcinoma. The Laryngoscope 2018, 129: 883-889. PMID: 30151947, DOI: 10.1002/lary.27444.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Squamous CellChemoradiotherapy, AdjuvantChemotherapy, AdjuvantCombined Modality TherapyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm StagingPropensity ScoreProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesSalivary Gland NeoplasmsSurvival RateTreatment OutcomeConceptsLate-stage patientsSquamous cell carcinomaAdjuvant radiotherapyAdjuvant therapyAdjuvant chemoradiotherapyAdjuvant chemotherapyImproved survivalCell carcinomaImproved long-term survivalCox survival regressionPrimary cutaneous malignanciesUnique disease entityAddition of chemotherapyNational Cancer DatabaseEarly-stage diseaseFive-year survivalEarly-stage patientsKaplan-Meier analysisParotid gland cancerLate stage groupLong-term survivalSurvival benefitCutaneous malignanciesPoor prognosisRetrospective study
2017
Treatment deintensification in human papillomavirus‐positive oropharynx cancer: Outcomes from the National Cancer Data Base
Cheraghlou S, Yu PK, Otremba MD, Park HS, Bhatia A, Zogg CK, Mehra S, Yarbrough WG, Judson BL. Treatment deintensification in human papillomavirus‐positive oropharynx cancer: Outcomes from the National Cancer Data Base. Cancer 2017, 124: 717-726. PMID: 29243245, DOI: 10.1002/cncr.31104.Peer-Reviewed Original ResearchConceptsNational Cancer Data BaseStage III diseaseTriple-modality therapyAdjuvant radiotherapyOropharyngeal cancerStage IHuman papillomavirus-positive oropharyngeal cancerUnivariate Kaplan-Meier analysisAvoidance of chemotherapyDeintensification of treatmentEdition stage IStage II diseaseMultivariate Cox regressionAmerican Joint CommitteeKaplan-Meier analysisDisease stage groupsForm of treatmentTreatment deintensificationAdjuvant chemoradiotherapyDefinitive radiotherapyTreatment intensificationFavorable prognosisImproved survivalCox regressionRetrospective studyAdjuvant Therapy Use and Survival in Stage II Endometrial Cancer
Lester-Coll NH, Young MR, Park HS, Ratner ES, Litkouhi B, Damast S. Adjuvant Therapy Use and Survival in Stage II Endometrial Cancer. International Journal Of Gynecological Cancer 2017, 27: 1904-1911. PMID: 28763364, DOI: 10.1097/igc.0000000000001095.Peer-Reviewed Original ResearchConceptsReceipt of chemotherapyEndometrioid endometrial carcinomaNational Cancer Data BaseImproved overall survivalRole of chemotherapyOverall survivalAdjuvant chemotherapyAdjuvant treatmentStage II endometrial cancerCox proportional hazards regressionPropensity scoreAdjuvant therapy useGrade 3 diseaseStage II patientsProportional hazards regressionWorse overall survivalMultivariable logistic regressionKaplan-Meier estimatesLog-rank testAdjuvant radiotherapyExcellent prognosisLymphovascular invasionObservational cohortEEC patientsEndometrial cancer
2016
Association between access to accelerated partial breast irradiation and use of adjuvant radiotherapy
Wang EH, Park HS, Rutter CE, Gross CP, Soulos PR, Yu JB, Evans SB. Association between access to accelerated partial breast irradiation and use of adjuvant radiotherapy. Cancer 2016, 123: 502-511. PMID: 27657353, DOI: 10.1002/cncr.30356.Peer-Reviewed Original ResearchConceptsBreast-conserving surgeryInvasive cancerDuctal carcinomaNational Cancer Data BaseEarly-stage breast cancerReceipt of radiotherapySubgroup multivariable analysisSubset of patientsMultivariable logistic regressionPartial breast irradiationOverall sampleRT receiptAdjuvant radiotherapyEligible patientsRT useMultivariable analysisRetrospective studyBreast irradiationBreast cancerIndependent factorsPatientsRadiotherapyCancerLogistic regressionAPBI
2015
The evolving role of adjuvant radiotherapy for elderly women with early‐stage breast cancer
Rutter CE, Lester-Coll NH, Mancini BR, Corso CD, Park HS, Yeboa DN, Gross CP, Evans SB. The evolving role of adjuvant radiotherapy for elderly women with early‐stage breast cancer. Cancer 2015, 121: 2331-2340. PMID: 25810128, DOI: 10.1002/cncr.29377.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerER-positive early-stage breast cancerRT useElderly patientsLogistic regression analysisBoost radiotherapyAdjuvant radiotherapyBreast cancerLeukemia Group B (CALGB) 9343 trialPositive early-stage breast cancerNational Cancer Data BaseMultivariable logistic regression analysisAvoidance of radiotherapyLocal control benefitNegative resection marginsYear of diagnosisUse of radiotherapyRegression analysisClinicopathologic covariatesRT detailsOlder patientsOverall survivalHypofractionated radiotherapyResection marginsEvidence-based practice
2011
Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis
Buscariollo DL, Park HS, Roberts KB, Yu JB. Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis. Cancer 2011, 118: 4212-4219. PMID: 22213196, DOI: 10.1002/cncr.27373.Peer-Reviewed Original ResearchConceptsAtypical teratoid rhabdoid tumorMedian overall survivalOverall survivalRT useLandmark analysisRhabdoid tumorRare central nervous system malignanciesNational Cancer Institute's SurveillanceCentral nervous system malignanciesCox proportional hazards modelRole of radiotherapyEnd Results (SEER) databaseEnd Results analysisSignificant survival benefitProspective clinical trialsGross total resectionPatients ages 4Nervous system malignanciesImmortal time biasProportional hazards modelLong-term survivorshipAdjuvant radiotherapyInitial radiotherapyPrimary endpointInitial management