2024
Real world outcomes of patients with small cell lung cancer (SCLC) presenting with brain metastasis at diagnosis in a single institution health system.
Joseph J, Matera R, Park H, Chiang V, Chiang A. Real world outcomes of patients with small cell lung cancer (SCLC) presenting with brain metastasis at diagnosis in a single institution health system. Journal Of Clinical Oncology 2024, 42: e20136-e20136. DOI: 10.1200/jco.2024.42.16_suppl.e20136.Peer-Reviewed Original ResearchExtensive-stage small cell lung cancerMedian progression free survivalSmall cell lung cancerGamma knife radiosurgeryMedian overall survivalBrain metsCell lung cancerBrain metastasesFree survivalBrain radiationExtensive-stage small cell lung cancer patientsPatients treated with Gamma Knife radiosurgeryLung cancerSmall cell lung cancer patientsAggressive lung cancer subtypePatients treated with chemoimmunotherapyUpfront gamma knife radiosurgerySingle-institution retrospective studyAdvanced radiation techniquesTreated with chemoimmunotherapyProgression free survivalOutcomes of patientsLung cancer subtypesFrontline chemoimmunotherapyPlatinum doublets
2019
Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials
Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Mahajan A, Omay S, Chiang V. Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials. Journal Of Radiation Oncology 2019, 8: 39-46. DOI: 10.1007/s13566-018-0370-7.Peer-Reviewed Original ResearchYale-New Haven HospitalPhase II studyBrain metastasesClinical trialsII studyKnife radiosurgeryLocal controlPre-defined primary endpointWhole-brain radiation treatmentFuture prospective clinical trialsEvaluable brain metastasesSymptomatic radiation necrosisMedian patient ageLocal control ratePhase 2 studyGood local controlProspective clinical trialsNumber of metastasesLarge clinical trialsProportional hazards regressionFuture clinical trialsGamma knife radiosurgeryImportant clinical variablesStandard clinical practiceNew Haven Hospital
2011
Delayed Radiation-Induced Vasculitic Leukoencephalopathy
Rauch PJ, Park HS, Knisely JP, Chiang VL, Vortmeyer AO. Delayed Radiation-Induced Vasculitic Leukoencephalopathy. International Journal Of Radiation Oncology • Biology • Physics 2011, 83: 369-375. PMID: 22024206, DOI: 10.1016/j.ijrobp.2011.06.1982.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryKnife radiosurgeryRadiation therapyYale-New Haven HospitalRadiation-induced leukoencephalopathyHigh-dose radiation fieldT cell infiltrationMetastatic brain cancerFocused radiation therapyMedium-sized vesselsNew Haven HospitalActive vasculitisLeukoencephalopathic changesVasculitic componentBrain metastasesVascular sclerosisNeuropathologic examinationSignificant morbiditySurgical managementTumor recurrencePathological evidenceHistopathologic observationsLeukoencephalopathyPathological differencesBrain cancer