2014
Prophylactic Cranial Irradiation for Patients With Locally Advanced Non–Small-Cell Lung Cancer at High Risk for Brain Metastases
Park HS, Decker RH, Wilson LD, Yu JB. Prophylactic Cranial Irradiation for Patients With Locally Advanced Non–Small-Cell Lung Cancer at High Risk for Brain Metastases. Clinical Lung Cancer 2014, 16: 292-297. PMID: 25499149, DOI: 10.1016/j.cllc.2014.11.005.Peer-Reviewed Original ResearchConceptsProphylactic cranial irradiationLA-NSCLC patientsSequential landmark analysesCell lung cancerBrain metastasesHigh riskCranial irradiationSurvival benefitLung cancerLandmark analysisEffect of PCICox proportional hazards regressionNon-PCI patientsOverall survival benefitEnd Results (SEER) databaseHigh-risk patientsStage III NSCLCGroup of patientsProportional hazards regressionLog-rank testSignificant survival differenceImmortal time biasPopulation-based analysisAdult patientsOnly patients
2012
Immortal Time Bias: A Frequently Unrecognized Threat to Validity in the Evaluation of Postoperative Radiotherapy
Park HS, Gross CP, Makarov DV, Yu JB. Immortal Time Bias: A Frequently Unrecognized Threat to Validity in the Evaluation of Postoperative Radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2012, 83: 1365-1373. PMID: 22342097, DOI: 10.1016/j.ijrobp.2011.10.025.Peer-Reviewed Original ResearchConceptsSequential landmark analysesPostoperative radiotherapyImmortal time biasLandmark analysisTumor typesEnd Results (SEER) databaseObservational cohort studyTime biasObservation cohortCohort studyHazard ratioProspective trialImproved survivalResults databaseConditional survivalRoutine useSurvivalApparent benefitRadiotherapyCohort
2011
Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis
Buscariollo DL, Park HS, Roberts KB, Yu JB. Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis. Cancer 2011, 118: 4212-4219. PMID: 22213196, DOI: 10.1002/cncr.27373.Peer-Reviewed Original ResearchConceptsAtypical teratoid rhabdoid tumorMedian overall survivalOverall survivalRT useLandmark analysisRhabdoid tumorRare central nervous system malignanciesNational Cancer Institute's SurveillanceCentral nervous system malignanciesCox proportional hazards modelRole of radiotherapyEnd Results (SEER) databaseEnd Results analysisSignificant survival benefitProspective clinical trialsGross total resectionPatients ages 4Nervous system malignanciesImmortal time biasProportional hazards modelLong-term survivorshipAdjuvant radiotherapyInitial radiotherapyPrimary endpointInitial management