2024
Real world outcomes of patients with small cell lung cancer (SCLC) presenting with brain metastasis at diagnosis in a single institution health system.
Joseph J, Matera R, Park H, Chiang V, Chiang A. Real world outcomes of patients with small cell lung cancer (SCLC) presenting with brain metastasis at diagnosis in a single institution health system. Journal Of Clinical Oncology 2024, 42: e20136-e20136. DOI: 10.1200/jco.2024.42.16_suppl.e20136.Peer-Reviewed Original ResearchExtensive-stage small cell lung cancerMedian progression free survivalSmall cell lung cancerGamma knife radiosurgeryMedian overall survivalBrain metsCell lung cancerBrain metastasesFree survivalBrain radiationExtensive-stage small cell lung cancer patientsPatients treated with Gamma Knife radiosurgeryLung cancerSmall cell lung cancer patientsAggressive lung cancer subtypePatients treated with chemoimmunotherapyUpfront gamma knife radiosurgerySingle-institution retrospective studyAdvanced radiation techniquesTreated with chemoimmunotherapyProgression free survivalOutcomes of patientsLung cancer subtypesFrontline chemoimmunotherapyPlatinum doublets
2021
Effect of prior thoracic radiotherapy on prognosis in relapsed small cell lung cancer patients treated with anlotinib: a subgroup analysis of the ALTER 1202 trial
Liu Y, Cheng Y, Li K, Shi J, Liu Y, Wu L, Han B, Chen G, He J, Wang J, Qin H, Li X, Hamaji M, Park HS. Effect of prior thoracic radiotherapy on prognosis in relapsed small cell lung cancer patients treated with anlotinib: a subgroup analysis of the ALTER 1202 trial. Translational Lung Cancer Research 2021, 10: 3793-3806. PMID: 34733629, PMCID: PMC8512470, DOI: 10.21037/tlcr-21-632.Peer-Reviewed Original ResearchDisease control rateProgression-free survivalObjective response rateSmall cell lung cancerOverall survivalThoracic radiotherapySubgroup analysisRT subgroupPlacebo-controlled phase 2 trialSmall cell lung cancer patientsCell lung cancer patientsPrevious thoracic radiotherapyPrior thoracic radiotherapyRelapsed SCLC patientsPhase 2 trialCell lung cancerLung cancer patientsOS benefitPFS benefitSCLC patientsPlacebo groupPlacebo armRT patientsCancer patientsControl rate
2015
Comparison of survival outcomes among standard radiotherapy regimens in limited-stage small cell lung cancer patients receiving concurrent chemoradiation
Rutter CE, Park HS, Corso CD, Yeboa DN, Mancini BR, Lester-Coll NH, Kim AW, Decker RH. Comparison of survival outcomes among standard radiotherapy regimens in limited-stage small cell lung cancer patients receiving concurrent chemoradiation. Lung Cancer 2015, 90: 243-248. PMID: 26277031, DOI: 10.1016/j.lungcan.2015.08.002.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerDose-fractionation regimensLimited-stage small cell lung cancerConcurrent CRTConcurrent chemoradiationOverall survivalLimited-stage small-cell lung cancer patientsProportional hazardsSmall cell lung cancer patientsMultivariable Cox proportional hazardsCell lung cancer patientsOptimal radiotherapy doseOngoing randomized trialsInferior overall survivalKaplan-Meier analysisCell lung cancerLarger tumor sizeMedian survival timeLung cancer patientsCox proportional hazardsStandard radiotherapy regimensLarge national datasetChemoradiation regimensSimilar OSEquivalent OS