1995
Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming
Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.Peer-Reviewed Original ResearchConceptsAlpha-granule releaseSodium nitroprusside infusionSodium nitroprussidePlatelet functionNitroprusside infusionPlatelet aggregationSodium nitroprusside administrationP-selectin expressionPlatelet-rich plasmaMeasures of plateletIntravenous crystalloidImpaired coagulationNitroprusside administrationAntiplatelet effectEpinephrine pretreatmentNormal volunteersVivo findingsHuman volunteersNitroprussideVivo inhibitionVitro inhibitionInhibitory effectSignificant inhibitionRapid reversibilityTime course
1993
Aspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release
Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release. Blood 1993, 82: 505-512. PMID: 7687162, DOI: 10.1182/blood.v82.2.505.505.Peer-Reviewed Original ResearchConceptsP-selectin expressionAlpha-granule secretionPlatelet alpha-granule secretionAspirin treatmentP-selectinGranule secretionPlatelet alpha-granule releaseArachidonic acidCyclooxygenase-dependent metabolitesPlatelet surface expressionPlatelet α-granule releasePlatelet dense granule secretionAlpha-granule releaseΑ-granule releaseDense granule secretionPolymorphonuclear lymphocytesAmiloride treatmentLipoxygenase inhibitorsAspirinSecretionWhole bloodPlatelet-platelet interactionsTreatmentInvolvement of metabolitesPlatelets
1991
Dynamics of leukocyte-platelet adhesion in whole blood.
Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of leukocyte-platelet adhesion in whole blood. Blood 1991, 78: 1730-7. PMID: 1717069, DOI: 10.1182/blood.v78.7.1730.bloodjournal7871730.Peer-Reviewed Original ResearchPlatelet Activation and Aggregation during Cardiopulmonary Bypass
Rinder C, Bohnert J, Rinder H, Mitchell J, Ault K, Hillman R. Platelet Activation and Aggregation during Cardiopulmonary Bypass. Anesthesiology 1991, 75: 388-393. PMID: 1716077, DOI: 10.1097/00000542-199109000-00002.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassPlatelet activationPlatelet aggregationExtracorporeal circulationEarly postoperative periodAlpha-granule releaseGMP-140 expressionPlatelet factor 4Granule membrane protein-140Alpha-granule membrane proteinPlatelet surface membranePostoperative periodPlatelet dysfunctionPlasma concentrationsIndividual patientsBypassFlow cytometryPlatelet defectsGranule productsMonoclonal antibodiesProtein 140Factor 4PlateletsPatientsAggregation defect