2002
Prospective Study of Eukaryotic Initiation Factor 4E Protein Elevation and Breast Cancer Outcome
Li B, Gruner J, Abreo F, Johnson L, Yu H, Nawas S, McDonald J, DeBenedetti A. Prospective Study of Eukaryotic Initiation Factor 4E Protein Elevation and Breast Cancer Outcome. Annals Of Surgery 2002, 235: 732-739. PMID: 11981220, PMCID: PMC1422500, DOI: 10.1097/00000658-200205000-00016.Peer-Reviewed Original ResearchConceptsCancer-related deathCancer recurrenceRelative riskBreast cancerIndependent predictorsReceptor statusProtein elevationHigh eIF4EMenopausal statusTumor sizeTumor gradeHigher cancer recurrence rateImportant independent prognostic markerKaplan-Meier survival curvesCox proportional hazards modelStage 1Progesterone receptor statusBreast cancer outcomesSmall retrospective studiesStage of diseaseEstrogen receptor statusCancer recurrence rateIndependent prognostic markerLog-rank testBreast cancer recurrence
1998
Insulin‐like growth factor–binding protein‐3 and breast cancer survival
Yu H, Levesque M, Khosravi M, Papanastasiou‐Diamandi A, Clark G, Diamandis E. Insulin‐like growth factor–binding protein‐3 and breast cancer survival. International Journal Of Cancer 1998, 79: 624-628. PMID: 9842972, DOI: 10.1002/(sici)1097-0215(19981218)79:6<624::aid-ijc12>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorActions of IGFsIGFBP-3IGF-binding proteinsBreast cancer recurrenceS-phase fractionTumor sizeCancer recurrenceBreast cancerInsulin-like growth factor-binding protein-3Elevated S-phase fractionHigher IGFBP-3 levelsInhibits breast cancer cell growthBreast cancer cell growthDiagnosis-matched patientsIGFBP-3 levelsUnfavourable prognostic featuresUnfavourable prognostic indicatorPrimary breast cancerEstrogen receptor expressionLarger tumor sizeRisk of deathBreast cancer survivalCase-control studyBreast tissue extracts