2023
Night shift work, sleep duration and endometrial cancer risk: A pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2)
Frias-Gomez J, Alemany L, Benavente Y, Clarke M, de Francisco J, De Vivo I, Du M, Goodman M, Lacey J, Liao L, Lipworth L, Lu L, Merritt M, Michels K, O'Connell K, Paytubi S, Pelegrina B, Peremiquel-Trillas P, Petruzella S, Ponce J, Risch H, Setiawan V, Schouten L, Shu X, Trabert B, Van den Brandt P, Wentzensen N, Wilkens L, Yu H, Costas L. Night shift work, sleep duration and endometrial cancer risk: A pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2). Sleep Medicine Reviews 2023, 72: 101848. PMID: 37716022, PMCID: PMC10840870, DOI: 10.1016/j.smrv.2023.101848.Peer-Reviewed Original ResearchConceptsNight shift workEndometrial Cancer ConsortiumEndometrial cancer riskEndometrial cancerSleep durationShift workPostmenopausal womenPooled analysisInverse associationOdds ratioCancer riskCancer ConsortiumNon-significant inverse associationStudy-specific odds ratiosEndometrial cancer casesStrong risk factorConfidence intervalsLong sleep durationDaily sleep durationObese womenRisk factorsCancer casesLogistic regressionIndividual dataCancerGenetic variants of glucose metabolism and exposure to smoking in African American breast cancer.
Jung S, Papp J, Sobel E, Pellegrini M, Yu H. Genetic variants of glucose metabolism and exposure to smoking in African American breast cancer. Endocrine Related Cancer 2023, 30 PMID: 36705562, PMCID: PMC10095926, DOI: 10.1530/erc-22-0184.Peer-Reviewed Original ResearchConceptsInsulin resistanceBC riskLifestyle factorsSingle nucleotide polymorphismsAA womenRisk genotypesAfrican American postmenopausal womenAfrican-American breast cancerRisk of BCBreast cancer developmentDose-dependent mannerPostmenopausal womenPositive BCPredictive markerRisk factorsFemale hormonesBreast cancerGlucose metabolismMetabolic biomarkersGene-environment interaction analysisSmokingPreventive interventionsCancer developmentWhite womenIndividual single nucleotide polymorphisms
2008
Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GY, Xue X, Anderson GL, Kaplan RC, Harris TG, Howard BV, Wylie-Rosett J, Burk RD, Strickler HD. Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 2008, 101: 48-60. PMID: 19116382, PMCID: PMC2639294, DOI: 10.1093/jnci/djn415.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBiomarkers, TumorBlood GlucoseBody Mass IndexBreast NeoplasmsCase-Control StudiesEstradiolEstrogen Replacement TherapyFemaleHumansHyperinsulinismInsulinInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiddle AgedMultivariate AnalysisObesityOdds RatioPostmenopauseProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsStatistics, NonparametricConceptsInsulin-like growth factorLevels of insulinBreast cancerInsulin levelsRisk factorsPostmenopausal womenGrowth factorMultiple breast cancer risk factorsMultivariable Cox proportional hazards modelsWomen's Health Initiative Observational StudyBreast cancer case subjectsBreast cancer risk factorsCox proportional hazards modelHormone therapy useIncident breast cancerIndependent risk factorPostmenopausal breast cancerCancer risk factorsCase-cohort studyProportional hazards modelTotal IGFNondiabetic womenBaseline characteristicsFree IGFProspective cohortA Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer
Gunter M, Hoover D, Yu H, Wassertheil-Smoller S, Manson J, Li J, Harris T, Rohan T, Xue X, Ho G, Einstein M, Kaplan R, Burk R, Wylie-Rosett J, Pollak M, Anderson G, Howard B, Strickler H. A Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 921-929. PMID: 18398032, PMCID: PMC3090086, DOI: 10.1158/1055-9965.epi-07-2686.Peer-Reviewed Original ResearchMeSH KeywordsAgedBody Mass IndexCarcinoma, EndometrioidEndometrial NeoplasmsEstradiolFemaleHumansHypoglycemic AgentsInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Middle AgedMulticenter Studies as TopicObesityProportional Hazards ModelsProspective StudiesRisk FactorsConceptsInsulin-like growth factorEndometrial cancerEndometrioid adenocarcinomaRisk factorsFree IGFObese womenEstrogen levelsWomen's Health Initiative Observational StudyFree IGF-I levelsIGF-binding protein-3Growth factorBaseline serum specimensIncident endometrial cancerHormone therapy useIGF-I levelsMain histologic typesCase-cohort studyMajor risk factorHigh estrogen levelsTotal IGFPostmenopausal womenHormone therapyProspective cohortRandom subcohortTherapy useInsulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Howard BV, Wylie-Rosett J, Anderson GL, Ho GY, Kaplan RC, Li J, Xue X, Harris TG, Burk RD, Strickler HD. Insulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women. Cancer Research 2008, 68: 329-337. PMID: 18172327, PMCID: PMC4225702, DOI: 10.1158/0008-5472.can-07-2946.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorFree IGFColorectal cancerPostmenopausal womenEndogenous estradiolWaist circumferenceWomen's Health Initiative Observational StudyIncident colorectal cancer casesGrowth factorBaseline serum specimensColorectal cancer incidenceColorectal cancer casesEndogenous estradiol levelsColorectal Cancer StudyStrong mitogenic effectIndependent biological pathwaysTotal IGFObese patientsProspective cohortRandom subcohortNondiabetic subjectsEstradiol levelsRisk factorsCancer incidenceExtreme quartiles
2004
Reports: Insulin-Like Growth Factor-I, Soy Protein Intake, and Breast Cancer Risk
Sanderson M, Shu X, Yu H, Dai Q, Malin A, Gao Y, Zheng W. Reports: Insulin-Like Growth Factor-I, Soy Protein Intake, and Breast Cancer Risk. Nutrition And Cancer 2004, 50: 8-15. PMID: 15572292, DOI: 10.1207/s15327914nc5001_2.Peer-Reviewed Original ResearchConceptsIGF-I levelsShanghai Breast Cancer StudyIGFBP-3 levelsSoy protein intakeBreast cancer riskCancer riskProtein intakeBreast cancerInsulin-like growth factor-binding protein-3 levelsPopulation-based case-control studyIncident breast cancer casesPremenopausal breast cancer riskPopulation-based cancer registriesBreast cancer cell growthInsulin-like growth factorPremenopausal breast cancerProtein-3 levelsEffects of IGFCase-control studyBreast cancer casesInsulin-like growthCancer cell growthBreast Cancer StudyPostmenopausal womenCancer RegistryIGF‐I and breast cancer: A meta‐analysis
Shi R, Yu H, McLarty J, Glass J. IGF‐I and breast cancer: A meta‐analysis. International Journal Of Cancer 2004, 111: 418-423. PMID: 15221971, DOI: 10.1002/ijc.20233.Peer-Reviewed Original ResearchConceptsHedges's standardized mean differenceIGFBP-3 levelsLevels of IGFIGF-binding proteinsBreast cancer riskStandardized mean differencePremenopausal womenBreast cancerIGFBP-3Cancer riskBreast cancer patientsEffects of IGFPostmenopausal womenPostmenopausal groupPremenopausal groupHigher IGFCancer patientsClinical studiesEpidemiologic studiesParacrine mechanismsIGFOverall associationMean differenceCancerWomen
2003
Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women.
Zheng S, Zheng W, Chang B, Shu X, Cai Q, Yu H, Dai Q, Xu J, Gao Y. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Cancer Research 2003, 63: 7624-9. PMID: 14633679.Peer-Reviewed Original ResearchConceptsBreast cancer riskEndogenous estrogen exposureEstrogen exposureCancer riskSteroid sex hormonesSex hormonesBreast cancerSingle nucleotide polymorphismsLong-term estrogen exposureChinese womenEstrogen receptor beta geneShanghai Breast Cancer StudyBreast Cancer StudyPostmenopausal womenFamily historyEstrogen synthesisCommon sequence variantsElevated riskGG genotypePotential synergistic effectsSequence variantsESR2 geneStrong associationWomenCancerUrinary phytoestrogen excretion and breast cancer risk: evaluating potential effect modifiers endogenous estrogens and anthropometrics.
Dai Q, Franke A, Yu H, Shu X, Jin F, Hebert J, Custer L, Gao Y, Zheng W. Urinary phytoestrogen excretion and breast cancer risk: evaluating potential effect modifiers endogenous estrogens and anthropometrics. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 497-502. PMID: 12814993.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAnthropometryBiomarkers, TumorBody Mass IndexBody WeightBreast NeoplasmsCase-Control StudiesChinaDehydroepiandrosterone SulfateEatingEstrogensFemaleFibroadenomaHumansIsoflavonesMenopauseMiddle AgedPhytoestrogensPlant PreparationsRisk FactorsSex Hormone-Binding GlobulinStatistics as TopicTestosteroneWomen's HealthConceptsBody mass indexBreast cancer riskUrinary phytoestrogen excretionSteroid sex hormonesSex hormonesCancer riskSteroid hormonesUrinary isoflavonoidsBlood levelsInverse associationBreast cancerExcretion rateEndogenous steroid sex hormonesHigher body mass indexMammalian lignansConditional logistic regression modelsPotential confounding factorsHigh blood concentrationsCase-control pairsPotential protective associationLogistic regression modelsPostmenopausal womenMorning bloodMass indexHip ratio
2002
Plasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors.
Chang S, Wu X, Yu H, Spitz M. Plasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors. Cancer Epidemiology Biomarkers & Prevention 2002, 11: 758-66. PMID: 12163330.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorIGF BP-3 levelsBody mass indexBP-3 levelsIGF BP-3IGF-II levelsHormone replacement therapyIGF-I levelsLow physical activityIGF levelsIGF-IIPhysical activityPostmenopausal womenHRT useCaloric intakeReproductive factorsLower IGF-II levelsTraditional cancer risk factorsLow IGF-I levelsPlasma insulin-like growth factorHigher body mass indexGrowth factorIGF-BP levelsPlasma IGF-IIRecent HRT use