2000
Serum and Urinary Prostate-specific Antigen and Urinary Human Glandular Kallikrein Concentrations Are Significantly Increased after Testosterone Administration in Female-to-Male Transsexuals
Obiezu C, Giltay E, Magklara A, Scorilas A, Gooren L, Yu H, Howarth D, Diamandis E. Serum and Urinary Prostate-specific Antigen and Urinary Human Glandular Kallikrein Concentrations Are Significantly Increased after Testosterone Administration in Female-to-Male Transsexuals. Clinical Chemistry 2000, 46: 859-862. PMID: 10839777, DOI: 10.1093/clinchem/46.6.859.Peer-Reviewed Original ResearchConceptsUrinary prostate specific antigenProstate-specific antigenTestosterone administrationSerum prostate-specific antigenMale transsexualsMonths of treatmentMonths post treatmentHK2 concentrationsSerum hK2Testosterone treatmentAndrogen administrationAndrogenic stimulationKallikrein concentrationImmunofluorometric methodTime pointsHK2AdministrationMonthsWomenTreatmentPost treatmentAntigenCultured cellsFemalesCorresponding mean values
1999
Prostate-specific antigen (PSA) in women.
Yu H, Berkel H. Prostate-specific antigen (PSA) in women. Journal Of The Louisiana State Medical Society 1999, 151: 209-13. PMID: 10234897.Peer-Reviewed Original ResearchConceptsProstate-specific antigenBreast cancerPSA levelsProduction of PSABetter disease-free survivalSerum prostate-specific antigenBreast tissueDisease-free survivalBreast cancer riskValuable tumor markerExcess androgenOverall survivalGestational agePregnant womenBreast fluidProgesterone receptorMenstrual cycleNipple aspiratesProstate cancerClinical studiesEstrogen receptorCancer riskTumor markersCyst fluidAmniotic fluid
1997
Prostate-Specific Antigen in Female Serum, a Potential New Marker of Androgen Excess
Melegos D, Yu H, Ashok M, Wang C, Stanczyk F, Diamandis E. Prostate-Specific Antigen in Female Serum, a Potential New Marker of Androgen Excess. The Journal Of Clinical Endocrinology & Metabolism 1997, 82: 777-780. PMID: 9062481, DOI: 10.1210/jcem.82.3.3792.Peer-Reviewed Original ResearchConceptsProstate-specific antigenMarker of androgen excessSerum prostate-specific antigenHirsute womenReceiver operating characteristicAndrogen actionAndrogen excessLevels of prostate-specific antigenProstate-specific antigen levelProstate-specific antigen geneFemale serumAction of steroid hormone receptorsMarker of androgen actionAlpha-androstanediol glucuronideSerum PSA levelsFerriman-Gallwey scorePotential new markerSteroid hormone receptorsPSA levelsProstate-specificHyperandrogenic statePatient ageAlpha-androstanediolAlpha-AgBiochemical markersDetection of Prostate Cancer Relapse With Prostate Specific Antigen Monitoring at Levels of 0.001 to 0.1 micro g./l
Yu H, Diamandis E, Wong P, Nam R, Trachtenberg J. Detection of Prostate Cancer Relapse With Prostate Specific Antigen Monitoring at Levels of 0.001 to 0.1 micro g./l. Journal Of Urology 1997, 157: 913-918. PMID: 9072598, DOI: 10.1016/s0022-5347(01)65082-1.Peer-Reviewed Original ResearchConceptsProstate-specific antigenPositive surgical marginsPreoperative prostate-specific antigenSerum prostate-specific antigenSerial serum samplesBiochemical relapseSurgical marginsClinicopathological featuresRadical prostatectomyTumor volumeLogistic regression modelsPSA changeGreater preoperative prostate specific antigenPostoperative serum prostate-specific antigenHigher preoperative prostate-specific antigenPostoperative prostate-specific antigenUnconditional logistic regression modelsSerum samplesProstate-specific antigen monitoringSerum PSA changesSubset of patientsUnivariate logistic regression modelYear of surgeryLength of followupConventional prostate specific antigenDetection of Prostate Cancer Relapse With Prostate Specific Antigen Monitoring at Levels of 0.001 to 0.1 micro g./l
Yu H, Diamandis E, Wong P, Nam R, Trachtenberg J. Detection of Prostate Cancer Relapse With Prostate Specific Antigen Monitoring at Levels of 0.001 to 0.1 micro g./l. Journal Of Urology 1997, 157: 913-918.. DOI: 10.1097/00005392-199703000-00047.Peer-Reviewed Original ResearchProstate-specific antigenPositive surgical marginsPreoperative prostate-specific antigenSerum prostate-specific antigenSerial serum samplesBiochemical relapseMicro g.Clinicopathological featuresSurgical marginsRadical prostatectomyTumor volumeLogistic regression modelsPSA changeGreater preoperative prostate specific antigenPostoperative serum prostate-specific antigenHigher preoperative prostate-specific antigenPostoperative prostate-specific antigenUnconditional logistic regression modelsSerum samplesProstate-specific antigen monitoringSerum PSA changesUnivariate logistic regression modelYear of surgerySubset of patientsLength of followup
1996
Prostate-specific antigen in amniotic fluid of normal and abnormal pregnancies
Melegos D, Yu H, Allen L, Diamandis E. Prostate-specific antigen in amniotic fluid of normal and abnormal pregnancies. Clinical Biochemistry 1996, 29: 555-562. PMID: 8939403, DOI: 10.1016/s0009-9120(96)00093-8.Peer-Reviewed Original ResearchConceptsProstate-specific antigenSerum PSA concentrationAmniotic fluidPregnant womenFetal abnormalitiesPSA concentrationNonpregnant womenGestational ageHigher serum PSA concentrationsSerum prostate-specific antigenGestational week 15Gestational weeks 11Median PSA concentrationGestational weeks 13Gender of fetusesPSA levelsMaternal serumAbnormal pregnanciesMaternal ageRenal disordersLength of abstinenceWeek 13Week 15Diagnostic usefulnessTime-resolved immunofluorometric procedure
1995
Prostate-specific antigen in serum of women with breast cancer
Giai M, Yu H, Roagna R, Ponzone R, Katsaros D, Levesque M, Diamandis E. Prostate-specific antigen in serum of women with breast cancer. British Journal Of Cancer 1995, 72: 728-731. PMID: 7545417, PMCID: PMC2033864, DOI: 10.1038/bjc.1995.401.Peer-Reviewed Original ResearchConceptsSerum prostate-specific antigenProstate-specific antigenBreast cancer patientsBreast cancerPSA levelsCancer patientsTumor cytosolsBreast tumorsPSA concentrationFree prostate-specific antigenSerum of womenFavorable prognostic indicatorSerum PSA levelsNormal male serumFemale breast tumorsBreast cancer diagnosisPresurgical seraPrognostic indicatorSurgical removalNormal breastMale serumCancerSerumCancer diagnosisTumorsOriginal Articles: Prostate Cancer: Measurement of Serum Prostate Specific Antigen Levels in Women and in Prostatectomized Men With an Ultrasensitive Immunoassay Technique
Yu H, Diamandis E. Original Articles: Prostate Cancer: Measurement of Serum Prostate Specific Antigen Levels in Women and in Prostatectomized Men With an Ultrasensitive Immunoassay Technique. Journal Of Urology 1995, 153: 1004-1008. PMID: 7531781, DOI: 10.1016/s0022-5347(01)67622-5.Peer-Reviewed Original ResearchConceptsSerum prostate-specific antigenProstate-specific antigenPSA levelsDetectable serum prostate specific antigenDistribution of PSAHigher serum prostate-specific antigenSerum prostate-specific antigen levelHealthy female blood donorsMeasurable prostate-specific antigenPostoperative prostate-specific antigenPreoperative prostate-specific antigenProstate-specific antigen levelYear of surgeryEvidence of relapseFemale blood donorsSpecific antigen levelsAge 50 yearsProstate cancer patientsHospitalized womenPatients 50Recurrent tumorsAntigen levelsHistological gradeCancer patientsRadical prostatectomyOriginal Articles
Yu H, Diamandis E. Original Articles. Journal Of Urology 1995, 153: 1004-1008.. DOI: 10.1097/00005392-199503000-00026.Peer-Reviewed Original ResearchSerum prostate-specific antigenProstate-specific antigenPSA levelsDetectable serum prostate specific antigenDistribution of PSAHigher serum prostate-specific antigenHealthy female blood donorsMeasurable prostate-specific antigenPostoperative prostate-specific antigenPreoperative prostate-specific antigenYear of surgeryEvidence of relapseFemale blood donorsAge 50 yearsProstate cancer patientsHospitalized womenPatients 50Recurrent tumorsHistological gradeCancer patientsRadical prostatectomyBlood donorsSpecific antigenFemale serumMicrograms