Loss of p19 ARF Eliminates the Requirement for the pRB-Binding Motif in Simian Virus 40 Large T Antigen-Mediated Transformation
Chao H, Buchmann A, DeCaprio J. Loss of p19 ARF Eliminates the Requirement for the pRB-Binding Motif in Simian Virus 40 Large T Antigen-Mediated Transformation. Molecular And Cellular Biology 2000, 20: 7624-7633. PMID: 11003658, PMCID: PMC86324, DOI: 10.1128/mcb.20.20.7624-7633.2000.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAnimalsAntigens, Viral, TumorBlotting, WesternCarrier ProteinsCell CountCell Cycle ProteinsCell DivisionCell Line, TransformedCell Transformation, NeoplasticContact InhibitionCyclin-Dependent Kinase Inhibitor p16DNA-Binding ProteinsE2F Transcription FactorsFibroblastsGene DeletionGene Expression Regulation, NeoplasticGenes, ReporterMicePromoter Regions, GeneticProtein BindingProteinsRetinoblastoma ProteinRetinoblastoma-Binding Protein 1Transcription Factor DP1Transcription FactorsTumor Suppressor Protein p14ARFTumor Suppressor Protein p53ConceptsMouse embryo fibroblastsLXCXE motifP53-binding domainJ-domainT antigenCellular transformationSequence-specific transcription factorsWild-type T antigenRetinoblastoma protein familyN-terminal 70 residuesHsp40/DnaJPRB family membersSimian virus 40 large T antigenAbility of p53Anchorage-independent growthLarge T antigenProtein familySignificant homologyTranscription factorsTerminal domainPRB-bindingPRb familyMutant derivativesMutant formsTumor suppressor