Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells
Libiad M, Vitvitsky V, Bostelaar T, Bak DW, Lee HJ, Sakamoto N, Fearon E, Lyssiotis CA, Weerapana E, Banerjee R. Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells. Journal Of Biological Chemistry 2019, 294: 12077-12090. PMID: 31213529, PMCID: PMC6690701, DOI: 10.1074/jbc.ra119.009442.Peer-Reviewed Original ResearchConceptsSulfide quinone oxidoreductaseSulfide oxidation pathwayElectron transfer chainColon epithelial cellsMetabolic reprogrammingGlutamine-dependent reductive carboxylationMitochondrial bioenergeticsMitochondrial sulfide oxidation pathwayCentral carbon metabolismEpithelial cellsHost-microbiome interfaceS oxidation pathwayCarbon metabolismHuman colonic cryptsOxidation pathwayPathway enzymesCellular bioenergeticsGut microbial metabolismStress responseMicrobial metabolismTransfer chainReductive carboxylationReductive shiftOxygen consumption rateQuinone oxidoreductaseReprogramming of Colonic Cell Metabolism by H2S
Vitvitsky V, Libiad M, Bostelaar T, Maebius A, Lee H, Lyssiotis C, Banerjee R. Reprogramming of Colonic Cell Metabolism by H2S. The FASEB Journal 2019, 33: 485.11-485.11. DOI: 10.1096/fasebj.2019.33.1_supplement.485.11.Peer-Reviewed Original ResearchOxygen consumption rateMitochondrial sulfide oxidation pathwayNumerous protein targetsSulfide oxidation pathwayEnergy metabolism pathwaysColon cancer tissuesMetabolic reprogrammingHuman colonic cellsInhibition of respirationProtein targetsStress responseNon-malignant cellsReductive carboxylationCell metabolismMetabolism pathwaysGrowth advantageInhibition of proliferationFASEB JournalCell exposurePathwayFull-text articlesColonic cellsGut microbiotaRespiratory toxinsCells