2023
eQTL studies: from bulk tissues to single cells
Zhang J, Zhao H. eQTL studies: from bulk tissues to single cells. Journal Of Genetics And Genomics 2023, 50: 925-933. PMID: 37207929, PMCID: PMC10656365, DOI: 10.1016/j.jgg.2023.05.003.Peer-Reviewed Original ResearchConceptsExpression quantitative trait lociBulk tissueIdentification of eQTLContext-dependent gene regulationCell typesQuantitative trait lociMost eQTL studiesSingle cellsComplex traitsGene regulationEQTL studiesFunctional genesTrait lociSpecific genesChromosomal regionsDynamic regulationGene expressionBiological processesDifferent tissuesGenetic variantsExpression levelsDisease mechanismsGenesRegulationRecent studies
2006
A Misclassification Model for Inferring Transcriptional Regulatory Networks
Vannucci M, Sun N, Zhao H. A Misclassification Model for Inferring Transcriptional Regulatory Networks. 2006, 347-365. DOI: 10.1017/cbo9780511584589.019.Peer-Reviewed Original ResearchTranscriptional regulatory networksGene expression dataRegulatory networksExpression dataUnderlying transcriptional regulatory networksProtein-DNA binding dataNetwork reconstructionSet of proteinsYeast cell cycleMutual regulatory interactionsRegulatory network reconstructionGene regulationRegulatory interactionsSpecific genesCell cycleGenesBiological researchExpression levelsProteinTRNBinding dataHigh connectivityTransient stimulationRecent advancesStatistical framework
2005
Integrating mRNA Decay Information into Co-Regulation Study
Chen L, Zhao H. Integrating mRNA Decay Information into Co-Regulation Study. Journal Of Computer Science And Technology 2005, 20: 434-438. DOI: 10.1007/s11390-005-0434-1.Peer-Reviewed Original ResearchMRNA decay ratesTranscript amountsTranscription rateBioinformatics analysisTranscriptional regulatory networksCo-regulated genesRelative transcript amountsMRNA degradation ratesHigh-throughput technologiesGene regulationGenomic signalsRegulatory networksDifferent genesGene clusteringMRNA synthesisMRNA transcriptsDownstream analysisGenesDNAMotifSimilarity analysisTranscriptsRegulationIdentification